2-丙烯基-吡啶 | 17618-94-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-丙烯基-吡啶
• 英文名称: 2-Propenyl-pyridin
• 英文别名: Methylvinylpyridine；2-prop-1-enylpyridine
• CAS: 17618-94-9
• 化学式: C₈H₉N
• 分子量: 119.166
• InChiKey: SMTDFMMXJHYDDE-UHFFFAOYSA-N

物化性质

• LogP：
  1.861 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-丙烯基-吡啶 在 platinum on activated charcoal 、 溶剂黄146 作用下， 生成 2-丙基哌啶
  参考文献：
  名称：

  Koller, Monatshefte fur Chemie, 1926, vol. 47, p. 394

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(1-hydroxypropyl)pyridine 在 PPA 作用下， 反应 0.25h， 生成 2-丙烯基-吡啶
  参考文献：
  名称：

  Synthesis of pyridines from alcohols in the system 1,3,5-triazine-polyphosphoric acid

  摘要：

  DOI：

  10.1134/s1070428009090206

文献信息

• Nickel Catalyzed Cross-Couplingand Amination Reactions of Aryl Nitriles
  作者：Joseph Miller、John Dankwardt、Jonathan Penney

  DOI：10.1055/s-2003-40873

  日期：2003.8

  Aryl nitriles have been found to participate in cross-coupling and amination reactions via nickel-catalyzed activation of the C-CN bond. With the development of these synthetically useful transformations, aryl nitriles can now be considered along with aryl halides and sulfonates as viable substrates for these types of reactions.

  已发现芳腈通过镍催化的 C-CN 键活化参与交叉偶联和胺化反应。随着这些合成有用的转化的发展，现在可以考虑将芳基腈与芳基卤化物和磺酸盐一起作为这些类型反应的可行底物。
• Nickel catalyzed cross-coupling of modified alkyl and alkenyl Grignard reagents with aryl- and heteroaryl nitriles: activation of the CCN bond
  作者：Joseph A Miller、John W Dankwardt

  DOI：10.1016/s0040-4039(03)00075-3

  日期：2003.2

  The nickel catalyzed cross-coupling of alkyl and alkenyl Grignard reagents with aryl nitrile derivatives affords good yields of the corresponding aryl alkanes or aryl alkenes via activation of the CCN bond. To prevent direct addition of the nucleophile to the nitrile group, the reactivity of the Grignard reagent was modulated by reaction with either LiOt-Bu or PhSLi prior to cross-coupling. The optimum

  烷基和链烯基格氏试剂与芳基腈衍生物的镍催化交叉偶联可通过CCN键的活化获得相应的芳基烷烃或芳基烯烃的良好收率。为了防止亲核试剂直接加成到腈基上，格利雅试剂的反应性通过在交叉偶联之前与LiO t- Bu或PhSLi反应来调节。确定最佳催化剂为NiCl 2（PMe 3）2，这是一种方便的，空气稳定的可商购的配合物。
• Borane‐Catalyzed Chemoselective and Enantioselective Reduction of 2‐Vinyl‐Substituted Pyridines
  作者：Jun‐Jie Tian、Zhao‐Ying Yang、Xin‐Shen Liang、Ning Liu、Chen‐Yu Hu、Xian‐Shuang Tu、Xiang Li、Xiao‐Chen Wang

  DOI：10.1002/anie.202007352

  日期：2020.10.12

  Herein, we report that highly chemoselective and enantioselective reduction of 2‐vinyl‐substituted pyridines has been achieved for the first time. The reaction, which uses chiral spiro‐bicyclic bisboranes as catalysts and HBpin and an acidic amide as reducing reagents, proceeds through a cascade process involving 1,4‐hydroboration followed by transfer hydrogenation of a dihydropyridine intermediate

  在此，我们报道了首次实现了2-乙烯基取代吡啶的高度化学选择性和对映选择性的还原。该反应使用手性螺双环双硼烷作为催化剂，HBpin和酸性酰胺作为还原剂，通过包括1,4-氢硼化的级联过程进行，然后转移氢化二氢吡啶中间体。还原产物中保留的双键可通过简单转化将其转化为天然产物和其他有用的杂环化合物。
• [EN] HUMAN PLASMA KALLIKREIN INHIBITORS<br/>[FR] INHIBITEURS DE LA KALLICRÉINE PLASMATIQUE HUMAINE
  申请人：BIOCRYST PHARM INC

  公开号：WO2015134998A1

  公开（公告）日：2015-09-11

  Disclosed are compounds of formula (I), as described herein, and pharmaceutically acceptable salts thereof. The compounds are inhibitors of plasma kallikrein. Also provided are pharmaceutical compositions comprising at least one compound of the invention, and methods involving use of the compounds and compositions of the invention in the treatment and prevention of diseases and conditions characterized by unwanted plasma kallikrein activity.

  本文披露的是公式（I）的化合物及其药用盐。这些化合物是血浆激肽酶的抑制剂。还提供了包含本发明化合物的药物组合物，以及涉及使用这些化合物和组合物治疗和预防由不需要的血浆激肽酶活性特征的疾病和症状的方法。
• Process for producing pyridylethylthio compound, modified ion exchanger and process for producing the same, and process for producing bisphenol compound
  申请人：Hayashi Hideto

  公开号：US20060041145A1

  公开（公告）日：2006-02-23

  The present invention relates to a process for producing a pyridylethylthio compound which is improved in yield of the pyridylethylthio compound. In a process for producing a pyridylethylthio compound by reacting vinyl pyridine with a sulfur-containing compound, vinyl pyridine used contains a compound represented by the general formula (1): (wherein R 1 and R 2 are any of combination of isopropenyl group and a hydrogen atom, combination of 1-propenyl group and a hydrogen atom, combination of 2-propenyl group and a hydrogen atom, and combination of methyl group and vinyl group), in an amount of not more than 4% by weight.

  本发明涉及一种生产吡啶乙硫基化合物的方法，该方法提高了吡啶乙硫基化合物的产量。通过将乙烯吡啶与含硫化合物反应生产吡啶乙硫基化合物的方法中，所使用的乙烯吡啶含有一种由通式（1）表示的化合物（其中R1和R2为异丙烯基和氢原子的任意组合、1-丙烯基和氢原子的任意组合、2-丙烯基和氢原子的任意组合，以及甲基基团和乙烯基团的任意组合），其含量不超过4%的重量。