[(Z)-3-Imidazol-1-yl-3-(2-isobutoxy-phenyl)-2-methyl-allyl]-dimethyl-amine | 108649-20-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: [(Z)-3-Imidazol-1-yl-3-(2-isobutoxy-phenyl)-2-methyl-allyl]-dimethyl-amine
• 英文别名: (Z)-3-imidazol-1-yl-N,N,2-trimethyl-3-[2-(2-methylpropoxy)phenyl]prop-2-en-1-amine
• CAS: 108649-20-3
• 化学式: C₁₉H₂₇N₃O
• 分子量: 313.443
• InChiKey: SMJUBHUOGMYWMZ-MNDPQUGUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  30.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-[(Z)-3-(dimethylamino)-1-imidazol-1-yl-2-methylprop-1-enyl]phenol 、 alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydride 作用下， 生成 [(Z)-3-Imidazol-1-yl-3-(2-isobutoxy-phenyl)-2-methyl-allyl]-dimethyl-amine
  参考文献：
  名称：

  Synthesis and antifungal activity of new 1-vinylimidazoles

  摘要：

  Carbonyl compounds I were subjected to an imidazole transfer reaction with N,N'-sulfinyldiimidazole or N,N'-carbonyldiimidazole to obtain the diimidazole II and the monoimidazole III. Various 1-vinylimidazoles IV, derived from o-hydroxyacetophenones by imidazole transfer reaction, were alkylated to furnish the title compounds V. The structure-activity relationships of these 1-vinylimidazole compounds V are described.

  DOI：

  10.1021/jm00391a014

文献信息

• Synthesis and antifungal activity of new 1-vinylimidazoles
  作者：Masaru Ogata、Hiroshi Matsumoto、Sumio Shimizu、Shiro Kida、Motoo Shiro、Katsuya Tawara

  DOI：10.1021/jm00391a014

  日期：1987.8

  Carbonyl compounds I were subjected to an imidazole transfer reaction with N,N'-sulfinyldiimidazole or N,N'-carbonyldiimidazole to obtain the diimidazole II and the monoimidazole III. Various 1-vinylimidazoles IV, derived from o-hydroxyacetophenones by imidazole transfer reaction, were alkylated to furnish the title compounds V. The structure-activity relationships of these 1-vinylimidazole compounds V are described.