N,N-diethyl-5,6,7,8-tetrapropylisoquinoline-1-carboxamide | 1609562-75-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: N,N-diethyl-5,6,7,8-tetrapropylisoquinoline-1-carboxamide
• CAS: 1609562-75-5
• 化学式: C₂₆H₄₀N₂O
• 分子量: 396.616
• InChiKey: NHNNDZOJGDUUHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  29
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  33.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-辛炔 、 尼可刹胺杂质1 在 silver hexafluoroantimonate 、 dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer 、 copper diacetate 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 24.0h， 以41%的产率得到N,N-diethyl-5,6,7,8-tetrapropylisoquinoline-1-carboxamide
  参考文献：
  名称：

  Efficient Synthesis of Isoquinolines via Rh(III)-Catalyzed Oxidative Annu­lation of Picolinamides with Alkynes

  摘要：

  An efficient synthesis of isoquinolines via Rh(III)-catalyzed oxidative annulation of picolinamides with alkynes using Cu(OAc)(2) as an oxidant has been developed. The scope of the reaction was studied with a selection of various picolinamides and alkynes, and the desired isoquinolines were obtained in good to excellent yields.

  DOI：

  10.1055/s-0033-1340870

文献信息

• Efficient Synthesis of Isoquinolines via Rh(III)-Catalyzed Oxidative Annu­lation of Picolinamides with Alkynes
  作者：Bing-Feng Shi、Zhen-Chao Qian、Jun Zhou、Bo Li

  DOI：10.1055/s-0033-1340870

  日期：——

  An efficient synthesis of isoquinolines via Rh(III)-catalyzed oxidative annulation of picolinamides with alkynes using Cu(OAc)(2) as an oxidant has been developed. The scope of the reaction was studied with a selection of various picolinamides and alkynes, and the desired isoquinolines were obtained in good to excellent yields.