(Z)-2-methoxy-5-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)phenyl acetate | 71198-73-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: (Z)-2-methoxy-5-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)phenyl acetate
• 英文别名: 2-Methoxy-5-[(Z)-(2-methyl-5-oxo-1,3-oxazol-4(5H)-ylidene)methyl]phenyl acetate；[2-methoxy-5-[(Z)-(2-methyl-5-oxo-1,3-oxazol-4-ylidene)methyl]phenyl] acetate
• CAS: 71198-73-7
• 化学式: C₁₄H₁₃NO₅
• 分子量: 275.261
• InChiKey: NHWRTLRYGLPIGJ-WDZFZDKYSA-N

物化性质

• 溶解度：
  >41.3 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  74.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (Z)-2-methoxy-5-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)phenyl acetate 以84%的产率得到
  参考文献：
  名称：

  MIYAKE, AKIO;ITOH, KATSUMI;AONO, TETSUYA;KISHIMOTO, SHOJI;MATSUSHITA, YOS+, J. TAKEDA RES. LAB., 1984, 43, N 3-4, 53-76

  摘要：

  DOI：
• 作为产物：
  描述：

  5-甲酰基-2-甲氧基苯基 乙酸酯 、 N-乙酰甘氨酸 在 sodium acetate 、 乙酸酐 作用下， 生成 (Z)-2-methoxy-5-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)phenyl acetate
  参考文献：
  名称：

  Direct determination of Z, E configuration of 4-arylidene-2-phenyl(methyl)-?2-oxazolin-5-ones and their solvolysis products by13c NMR

  摘要：

  DOI：

  10.1007/bf00961606

文献信息

• NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREFOR
  申请人：Chung Hae Young

  公开号：US20140023603A1

  公开（公告）日：2014-01-23

  Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPARα and PPARγ activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease.

  提供了一种具有美白皮肤、抗氧化和PPAR活性的新化合物及其医疗用途，该化合物具有美白皮肤的活性，可抑制酪氨酸酶，因此适用于用于美白皮肤的药物组合物或化妆品；具有抗氧化活性，因此适用于预防和治疗皮肤老化；具有PPAR活性，特别是PPARα和PPARγ活性，因此适用于用于预防和治疗肥胖、代谢性疾病或心血管疾病的药物组合物或保健食品。
• ROSMARINIC ACID DERIVATIVE OR SALT THEREOF
  申请人：KAO CORPORATION

  公开号：US20210300859A1

  公开（公告）日：2021-09-30

  The present invention provides a compound that inhibits the activity of TRPV4 and is useful for prevention or amelioration of an overactive bladder, an irritable bowel syndrome, etc. The compound is a rosmarinic acid derivative represented by the following formula (I) or a salt thereof:

  本发明提供了一种抑制TRPV4活性的化合物，可用于预防或改善过度活跃的膀胱、肠易激综合征等。该化合物是以下式（I）所代表的迷迭香酸衍生物或其盐：
• NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREOF
  申请人：Pusan National University Industry-University Cooperation Foundation

  公开号：US20160102065A1

  公开（公告）日：2016-04-14

  Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPARα and PPARγ activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease.

  提供了一种具有美白、抗氧化和PPAR活性的新化合物及其医疗用途。该化合物具有抑制酪氨酸酶的美白活性，因此可用于美白药物组合物或化妆品产品；具有抗氧化活性，因此可用于预防和治疗皮肤老化；具有PPAR活性，特别是PPARα和PPARγ活性，因此可用于有效预防和治疗肥胖症、代谢疾病或心血管疾病的药物组合物或保健食品。
• TRPV4 ACTIVITY INHIBITOR
  申请人：KAO CORPORATION

  公开号：US20210346331A1

  公开（公告）日：2021-11-11

  Provided is a compound that inhibits the activity of TRPV4 and is useful for preventing or ameliorating overactive bladder, irritable bowel syndrome, and the like. A TRPV4 activity inhibitor is provided containing a rosmarinic acid derivative selected from the group consisting of the following formulas (Ia) to (Id), or a salt thereof, as an active ingredient.
• US9216148B2
  申请人：——

  公开号：US9216148B2

  公开（公告）日：2015-12-22