3-oxaoctanoyl chloride | 108345-45-5

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 英文名称: 3-oxaoctanoyl chloride
• 英文别名: pentyloxy-acetyl chloride；n-Amyloxy-acetylchlorid；O-n-Amyl-glykoloylchlorid；2-Pentoxyacetyl chloride；2-pentoxyacetyl chloride
• CAS: 108345-45-5
• 化学式: C₇H₁₃ClO₂
• 分子量: 164.632
• InChiKey: ASUYHRXVTWBPFH-UHFFFAOYSA-N

物化性质

• 沸点：
  198.7±13.0 °C(Predicted)
• 密度：
  1.035±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-oxaoctanoyl chloride 、 六苯酚 在 吡啶 、 4-二甲氨基吡啶 作用下， 反应 48.0h， 以35%的产率得到
  参考文献：
  名称：

  The influence of heteroatoms and branchings on the liquid-crystalline properties of cyclotriveratrylene derivatives

  摘要：

  The synthesis and properties of novel pyramidic liquid crystals are reported. 2,3,7,8,12,13-Hexaacyloxy-10, 15-dihydro-5H-tribenzo [a,d,g]cyclononenes incorporate heteroatoms (O or S) in different positions in the lateral chains. The mesomorphic properties of these compounds were investigated by polarizing light microscopy, calorimetry and X-ray scattering. Most of the compounds display broad ranges of different columnar mesophases (D-hd, D-rd, D-ob). It was found that the mesophase stability of the 3-oxaalkanoates is increased in comparison to the analogous alkanoates. However, the shift of the oxygen atoms into the 4 positions leads to a destabilization of the mesophases. The 3-thiaalkanoate displays approximately the same clearing temperature as the corresponding carbon analogue. Branching of the lateral chains gives rise to discotic liquid crystals with broad mesomorphic ranges and increased clearing temperatures, compared to the corresponding non-branched derivatives.

  DOI：

  10.1039/jm9960601283

文献信息

• [EN] NOVEL 2-ARYLTHIAZOLE COMPOUNDS AS PPARALPHA AND PPARGAMA AGONISTS<br/>[FR] NOUVEAUX COMPOSES 2-ARYLTHIAZOLE UTILISES COMME AGONISTES DES RECEPTEURS PPARALPHA ET PPARGAMMA
  申请人：HOFFMANN LA ROCHE

  公开号：WO2004020420A1

  公开（公告）日：2004-03-11

  The present invention relates to compounds of formula (I) wherein Rl to R10, X, Y and n are as defined in the description and claims, and pharmaceutically acceptable salts and esters thereof. The compounds are useful for the treatment of diseases such as diabetes.

  本发明涉及式(I)的化合物，其中R1至R10、X、Y和n如描述和权利要求中所定义，并且其药学上可接受的盐和酯。这些化合物对于治疗疾病如糖尿病是有用的。
• Pyrrolobenzodiazepines and heteroaryl, aryl and cycloalkylamino ketone derivatives as follicle stimulating hormone receptor (FSH-R) antagonists
  申请人：Failli A. Amedeo

  公开号：US20060258644A1

  公开（公告）日：2006-11-16

  The invention provides compounds of formula or a pharmaceutically acceptable salt thereof, wherein R, R 1 , R 2 , R 3 , A, and B are as defined in the accompanying specification. Methods of making such compounds are also provided.

  本发明提供了公式化合物或其药学上可接受的盐，其中R、R1、R2、R3、A和B如附带规范所定义。同时提供了制备此类化合物的方法。
• Thiazole derivatives
  申请人：——

  公开号：US20040110807A1

  公开（公告）日：2004-06-10

  The present invention provides compounds of formula (I) 1 wherein R 1 to R 10 , X, Y and n are indicated in the specification, and pharmaceutically acceptable salts and esters thereof. The compounds are useful for the treatment of non-insulin dependent diabetes mellitus.

  本发明提供了式(I)1的化合物，其中R1至R10、X、Y和n在规范中指定，并且其药学上可接受的盐和酯。该化合物可用于治疗非胰岛素依赖型糖尿病。
• Diaminopyrimidine derivatives as selective growth hormone secrectgogue receptor (GHS-R) antagonists
  申请人：Xin Zhili

  公开号：US20050171132A1

  公开（公告）日：2005-08-04

  The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the action of ghrelin receptor, including Prader-Willi syndrome, eating disorder, weight gain, weight-loss maintainance following diet and exercise, obesity and disorders associated with obesity such as non-insulin dependent diabetes mellitus.

  本发明涉及式（I）的化合物，或其治疗上适宜的盐或前药，以及该化合物的制备、含有该化合物的组合物以及在预防或治疗由胃饥饿素受体调节的疾病中使用该化合物，包括普拉德-威利综合症、进食障碍、体重增加、饮食和运动后体重减轻维持、肥胖症以及与肥胖症相关的疾病，如非胰岛素依赖性糖尿病。
• Liquid crystals. 1. .beta.-Oxygen effect on stabilization of hexakis(acyloxy)benzene mesophase
  作者：Iwao Tabushi、Kazuo Yamamura、Yukihiro Okada

  DOI：10.1021/jo00388a029

  日期：1987.6