dipentyl(methylene)bis(4,1-phenylene)dicarbamate | 102894-35-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dipentyl(methylene)bis(4,1-phenylene)dicarbamate
• 英文别名: N,N'-(4,4'-methanediyl-di-phenyl)-bis-carbamic acid dipentyl ester；N,N'-(4,4'-Methandiyl-di-phenyl)-bis-carbamidsaeure-dipentylester；Bis-(4-pentyloxycarbonylamino-phenyl)-methan；pentyl N-[4-[[4-(pentoxycarbonylamino)phenyl]methyl]phenyl]carbamate
• CAS: 102894-35-9
• 化学式: C₂₅H₃₄N₂O₄
• 分子量: 426.556
• InChiKey: YVNBNGVMCPLUNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  31
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  氯甲酸正戊酯 、 4,4'-二氨基二苯甲烷 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以88%的产率得到dipentyl(methylene)bis(4,1-phenylene)dicarbamate
  参考文献：
  名称：

  双（4-氨基苯基）甲烷的双磺酰胺/氨基甲酸酯衍生物的合成，抗菌和抗氧化活性

  摘要：

  一系列新的双磺酰胺/双（4-氨基苯基）甲烷的氨基甲酸酯衍生物3（A-d）/ 5（A-F ）从双- （4-氨基苯基）甲烷（合成1用各种药理学活性的磺酰基）氯化物2（a–d）和碳酰氯4（a–f）高产。所有新合成化合物的结构均通过红外光谱，NMR（1 H和13 C），质量和元素分析进行了表征。此外，所有合成的化合物均通过使用2、2-二苯基-1-吡啶甲基肼基，NO和H进行了抗氧化活性测试。2 O 2清除方法和抗菌活性。大多数化合物表现出良好的抗氧化和抗菌活性。

  DOI：

  10.1002/jccs.201900434

文献信息

• ISOCYANATE PRODUCTION PROCESS
  申请人：Shinohata Masaaki

  公开号：US20110092731A1

  公开（公告）日：2011-04-21

  An object of the present invention is to provide a process that enables isocyanate to be produced stably over a long period of time and at high yield without encountering problems of the prior art during production of isocyanate without using phosgene. The present invention discloses a process for producing an isocyanate by subjecting a carbamic acid ester to a thermal decomposition reaction, including the steps of: recovering a low boiling point component in a form of a gaseous phase component from a thermal decomposition reaction vessel in which the thermal decomposition reaction is carried out; recovering a liquid phase component containing a carbamic acid ester from a bottom of the thermal decomposition reaction vessel; and supplying all or a portion of the liquid phase component to an upper portion of the thermal decomposition reaction vessel.

  本发明的一个目的是提供一种能够在长时间内稳定地高产且不使用光气的情况下生产异氰酸酯的方法，而不会遇到先前生产异氰酸酯时的问题。本发明公开了一种通过将氨基甲酸酯经受热分解反应来生产异氰酸酯的方法，包括以下步骤：从进行热分解反应的反应釜中回收形成气相组分的低沸点组分；从热分解反应釜底部回收含有氨基甲酸酯的液相组分；并将全部或部分液相组分供给至热分解反应釜的上部。
• PROCESS FOR PRODUCING ISOCYANATES
  申请人：Shinohata Masaaki

  公开号：US20100029981A1

  公开（公告）日：2010-02-04

  An object of the present invention is to provide a process that enables isocyanates to be stably produced over a long period of time at high yield without encountering various problems as found in the prior art when producing isocyanates without using phosgene. The present invention discloses a process for producing an isocyanate, comprising the steps of: reacting a carbamic acid ester and an aromatic hydroxy compound to obtain an aryl carbamate having a group derived from the aromatic hydroxy compound; and subjecting the aryl carbamate to a decomposition reaction, wherein the aromatic hydroxy compound is an aromatic hydroxy compound which is represented by the following formula (1) and which has a substituent R 1 at least one ortho position of a hydroxyl group: (wherein ring A represents an aromatic hydrocarbon ring in a form of a single or multiple rings which may have a substitute and which have 6 to 20 carbon atoms; R 1 represents a group other than a hydrogen atom in a form of an aliphatic alkyl group having 1 to 20 carbon atoms, an aliphatic alkoxy group having 1 to 20 carbon atoms, an aryl group having 6 to 20 carbon atoms, an aryloxy group having 6 to 20 carbon atoms, an aralkyl group having 7 to 20 carbon atoms or an aralkyloxy group having 7 to 20 carbon atoms, the group containing an atom selected from a carbon atom, an oxygen atom and a nitrogen atom; and R 1 may bond with A to form a ring structure).

  本发明的目的是提供一种过程，使得在不使用光气的情况下，能够稳定地高产长时间生产异氰酸酯，而不会遇到生产异氰酸酯时在先前技术中发现的各种问题。本发明公开了一种生产异氰酸酯的方法，包括以下步骤：反应一个氨基甲酸酯和一个芳香羟基化合物以获得含有源自芳香羟基化合物的基团的芳基氨基甲酸酯；并将芳基氨基甲酸酯进行分解反应，其中芳香羟基化合物是由以下式（1）表示并且在羟基位置的至少一个邻位上具有取代基R1的芳香羟基化合物：（其中，环A表示一个具有单个或多个环，并且可能具有取代基的芳香烃环，其具有6至20个碳原子；R1表示除氢原子外的基团，以具有1至20个碳原子的脂肪基烷基团，具有1至20个碳原子的脂肪基烷氧基团，具有6至20个碳原子的芳基团，具有6至20个碳原子的芳氧基团，具有7至20个碳原子的芳基烷基团或具有7至20个碳原子的芳基烷氧基团，该基团含有从碳原子、氧原子和氮原子中选择的原子；并且R1可以与A结合形成一个环状结构）。
• ISOCYANATE PRODUCTION PROCESS USING COMPOSITION CONTAINING CARBAMIC ACID ESTER AND AROMATIC HYDROXY COMPOUND, AND COMPOSITION FOR TRANSFER AND STORAGE OF CARBAMIC ACID ESTER
  申请人：Shinohata Masaaki

  公开号：US20100113823A1

  公开（公告）日：2010-05-06

  An object of the present invention is to provide an isocyanate production process, which is free of the various problems found in the prior art, and which uses a composition containing a carbamic acid ester and an aromatic hydroxy compound when producing isocyanate without using phosgene, as well as a carbamic acid ester composition for transferring or storing carbamic acid ester. The present invention discloses an isocyanate production process including specific steps and using a composition containing a carbamic acid ester and an aromatic hydroxy compound, as well as a composition for transfer or storage of carbamic acid ester comprising the carbamic acid ester and the specific aromatic hydroxy compound.

  本发明的目的是提供一种异氰酸酯生产工艺，该工艺不使用光气，使用含有碳酸酯和芳香羟基化合物的组合物生产异氰酸酯，避免了先前技术中发现的各种问题，以及用于转移或储存碳酸酯的碳酸酯组合物。本发明揭示了一种异氰酸酯生产工艺，包括特定步骤和使用含有碳酸酯和芳香羟基化合物的组合物，以及用于转移或储存碳酸酯的组合物，包括碳酸酯和特定的芳香羟基化合物。
• Isocyanate Production Process Using Composition Containing Carbamic Acid Ester and Aromatic Hydroxy Compound, and Composition for Transfer and Storage of Carbamic Acid Ester
  申请人：Asahi Kasei Chemicals Corporation

  公开号：US20150259279A1

  公开（公告）日：2015-09-17

  An object of the present invention is to provide an isocyanate production process, which is free of the various problems found in the prior art, and which uses a composition containing a carbamic acid ester and an aromatic hydroxy compound when producing isocyanate without using phosgene, as well as a carbamic acid ester composition for transferring or storing carbamic acid ester. The present invention discloses an isocyanate production process including specific steps and using a composition containing a carbamic acid ester and an aromatic hydroxy compound, as well as a composition for transfer or storage of carbamic acid ester comprising the carbamic acid ester and the specific aromatic hydroxy compound.

  本发明的目的是提供一种异氰酸酯生产工艺，该工艺不使用光气，使用含有氨基甲酸酯和芳香羟基化合物的组合物生产异氰酸酯，避免了先前技术中出现的各种问题，以及一种用于转移或储存氨基甲酸酯的氨基甲酸酯组合物。本发明揭示了一种包括特定步骤并使用含有氨基甲酸酯和芳香羟基化合物的组合物的异氰酸酯生产工艺，以及用于转移或储存氨基甲酸酯的组合物，包括氨基甲酸酯和特定的芳香羟基化合物。
• METHOD FOR PRODUCING ISOCYANATE
  申请人：Asahi Kasei Chemicals Corporation

  公开号：EP2088137A1

  公开（公告）日：2009-08-12

  An object of the present invention is to provide a process that enables isocyanates to be stably produced over a long period of time at high yield without encountering various problems as found in the prior art when producing isocyanates without using phosgene. The present invention discloses a process for producing an isocyanate, comprising the steps of: reacting a carbamic acid ester and an aromatic hydroxy compound to obtain an aryl carbamate having a group derived from the aromatic hydroxy compound; and subjecting the aryl carbamate to a decomposition reaction, wherein the aromatic hydroxy compound is an aromatic hydroxy compound which is represented by the following formula (1) and which has a substituent R1 at at least one ortho position of a hydroxyl group: (wherein ring A represents an aromatic hydrocarbon ring in a form of a single or multiple rings which may have a substitute and which have 6 to 20 carbon atoms; R1 represents a group other than a hydrogen atom in a form of an aliphatic alkyl group having 1 to 20 carbon atoms, an aliphatic alkoxy group having 1 to 20 carbon atoms, an aryl group having 6 to 20 carbon atoms, an aryloxy group having 6 to 20 carbon atoms, an aralkyl group having 7 to 20 carbon atoms or an aralkyloxy group having 7 to 20 carbon atoms, the group containing an atom selected from a carbon atom, an oxygen atom and a nitrogen atom; and R1 may bond with A to form a ring structure).

  本发明的目的是提供一种工艺，使异氰酸酯能够长期稳定地高产生产，而不会遇到现有技术中在不使用光气生产异氰酸酯时发现的各种问题。本发明公开了一种生产异氰酸酯的工艺，包括以下步骤：使氨基甲酸酯和芳香族羟基化合物反应，得到芳基氨基甲酸酯，其基团来自芳香族羟基化合物；使芳基氨基甲酸酯进行分解反应，其中芳香族羟基化合物是由下式（1）表示的芳香族羟基化合物，在羟基的至少一个正交位置上具有取代基 R1： (其中环 A 代表单环或多环形式的芳香烃环，可有取代基，具有 6 至 20 个碳原子； R1 代表氢原子以外的基团，其形式为具有 1 至 20 个碳原子的脂肪族烷基、具有 1 至 20 个碳原子的脂肪族烷氧基、具有 6 至 20 个碳原子的芳基、具有 6 至 20 个碳原子的芳氧基、具有 7 至 20 个碳原子的芳烷基或具有 7 至 20 个碳原子的芳氧基，该基团含有选自碳原子、氧原子和氮原子的原子；且 R1 可与 A 结合形成环结构）。