4-chloro-6-methylpyrimidine-2-thiol | 1240622-76-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-chloro-6-methylpyrimidine-2-thiol
• 英文别名: 4-Chloro-6-methylpyrimidine-2(1H)-thione；4-chloro-6-methyl-1H-pyrimidine-2-thione
• CAS: 1240622-76-7
• 化学式: C₅H₅ClN₂S
• 分子量: 160.627
• InChiKey: CYLFTMLOLVZSRH-UHFFFAOYSA-N

物化性质

• 沸点：
  230.4±23.0 °C(Predicted)
• 密度：
  1.44±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  56.5
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2933599090

反应信息

• 作为反应物：
  描述：

  4-chloro-6-methylpyrimidine-2-thiol 在 甲烷磺酸 、 三乙胺 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 1.0h， 生成 N-(2-((benzothiazol-2-yl)methylthio)-6-methylpyrimidin-4-yl)benzothiazol-2-amine
  参考文献：
  名称：

  Synthesis, antimicrobial and cytotoxic activities of pyrimidinyl benzoxazole, benzothiazole and benzimidazole

  摘要：

  A variety of pyrimidinyl benzoxazoles, benzothiazoles and benzimidazoles linked by thio, methylthio and amino moieties were prepared and studied their antimicrobial and cytotoxic activities. The compound pyrimidinyl bis methylthio benzimidazole 22 was a potent antimicrobial agent particularly against Staphylococcus aureus (29 mm, MIC 12.5 mu g/mL) and Penicillium chrysogenum (38 mm, MIC 12.5 mu g/mL). The amino linked pyrimidinyl bis benzothiazole 24 exhibited cytotoxic activity on A549 cells with IC50 value of 10.5 mu M. (C) 2014 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2014.02.050

文献信息

• Synthesis and antimicrobial activity of pyrimidinyl 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles
  作者：M. Madhu Sekhar、U. Nagarjuna、V. Padmavathi、A. Padmaja、N. Vasudeva Reddy、T. Vijaya

  DOI：10.1016/j.ejmech.2017.12.067

  日期：2018.2

  methylthio linked pyrimidinyl 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles were prepared under conventional and ultrasound irradiation methods. All the compounds were obtained in higher yields and in shorter reaction times in ultrasound irradiation method when compared with the conventional method. The title compounds were tested for antimicrobial activity. The compounds 12c and 12f exhibited

  在常规和超声照射方法下制备了一类新型甲硫基连接的嘧啶基 1,3,4-恶唑、1,3,4-噻二唑和 1,2,4-三唑。与传统方法相比，超声辐照法以更高的产率和更短的反应时间获得了所有化合物。对标题化合物进行了抗菌活性测试。化合物 12c 和 12f 对铜绿假单 胞菌表现出有希望的抗菌活性，而化合物 13c 和 13f 对黑曲 霉表现出明显的抗真菌活性。
• Aminopyrimidines useful as kinase inhibitors
  申请人：Binch Hayley

  公开号：US20080032963A1

  公开（公告）日：2008-02-07

  The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

  本发明涉及用作Aurora蛋白激酶抑制剂的化合物。本发明还提供包含这些化合物的药学上可接受的组合物以及使用这些化合物和组合物治疗各种疾病、病况和障碍的方法。本发明还提供制备本发明化合物的方法。
• AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS
  申请人：Studley John

  公开号：US20120095014A1

  公开（公告）日：2012-04-19

  The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

  本发明涉及用作Aurora蛋白激酶抑制剂的化合物。该发明还提供了包含这些化合物的药学上可接受的组合物以及使用这些化合物和组合物治疗各种疾病、病况和障碍的方法。该发明还提供了制备本发明化合物的方法。
• US7820685B2
  申请人：——

  公开号：US7820685B2

  公开（公告）日：2010-10-26
• US8129399B2
  申请人：——

  公开号：US8129399B2

  公开（公告）日：2012-03-06