2-乙基-6-甲基苯甲醛 | 106976-44-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-乙基-6-甲基苯甲醛
• 英文名称: 2-ethyl-6-methylbenzaldehyde
• CAS: 106976-44-7
• 化学式: C₁₀H₁₂O
• mdl: MFCD09999848
• 分子量: 148.205
• InChiKey: QUEDYNFRLQIQHB-UHFFFAOYSA-N

物化性质

• 沸点：
  230.5±9.0 °C(Predicted)
• 密度：
  0.986±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2912299000

反应信息

• 作为反应物：
  描述：

  2-乙基-6-甲基苯甲醛 在 sodium tetrahydroborate 、 水 作用下， 以 甲醇 、 乙醚 为溶剂， 反应 1.0h， 生成 (2-乙基-6-甲基苯基)甲醇
  参考文献：
  名称：

  WO2006/100119

  摘要：

  公开号：
• 作为产物：
  描述：

  2-ethyl-6-methylcarbomethoxybenzene 在 lithium aluminium tetrahydride 、 pyridinium chlorochromate 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 4.0h， 生成 2-乙基-6-甲基苯甲醛
  参考文献：
  名称：

  Rotational barriers of bis(2,6-disubstituted-aryl) ketones and bis(2,6-disubstituted-aryl)methanes and -ethanes and their mono- and bis(tricarbonylchromium) complexes

  摘要：

  DOI：

  10.1021/jo00383a006

文献信息

• [EN] WATER COMPATIBLE STERICALLY HINDERED ALKOXYAMINES AND HYDROXY SUBSTITUTED ALKOXYAMINES<br/>[FR] ALCOXYAMINES STERIQUEMENT ENCOMBREES ET ALCOXYAMINES HYDROXY SUBSTITUEES HYDROCOMPATIBLES
  申请人：CIBA SC HOLDING AG

  公开号：WO2004076419A1

  公开（公告）日：2004-09-10

  Sterically hindered alkoxyamine and hydroxy substituted alkoxyamine stabilizer compounds are made water compatible via certain backbones with affinity towards water. The sterically hindered amines are for example of the formula where for example E and E’ are 2-hydroxycydohexyloxy, 2-hydroxy-2-methylpropoxy, benzyloxy, methoxy, propoxy, hexyloxy, heptyloxy, oclyloxy or cyclohexyloxy, Rx is for example -NH2+CH2CH20H Cl-, -NH3+ -OAc, =NOH, -NHCH(CH3)COO-K+,- NHCH2CH2NH(CH3)2+ -OAC, -NHCH2CH2SO3-K+, -NHCH(COO- K+)CH2CH2SCH3, -NHCH2COO- K+, -OCH(CH3)COO-K+, -OCH2CH2NH(CH3)2+ -OAC, -OCH2CH2SO3-K+, -OCH(COO- K+)CH2CH2SCH3 or -OCH2COO-K+, and where R5 comprises repeating units of -(OCH2CH2)-, -(OCH2CH2(CH3))-,-(CH2CHCOOH)-, -(CH2C(CH3)COOH)-, -(CH2CHCOOCH3)-, -(NHCH2CH2)-, -(CH2CHOH)-, -(CH2CHCONH2)-or -(CH2CH(NHCOH))-. These compounds are particularly effective in stabilizing aqueous polymer systems against the deleterious effects of oxidative, thermal and actinic radiation. The compounds are effective for example in stabilizing water borne coatings, aqueous inks, aqueous inkjet media and photocured aqueous systems.

  通过具有亲水性的特定骨架，使具有立体位阻的烷氧胺和羟基取代的烷氧胺稳定剂化合物与水相容。其中，立体位阻胺的示例为以下公式，其中 E 和 E’ 为 2-羟基环己氧基、2-羟基-2-甲基丙氧基、苄氧基、甲氧基、丙氧基、己氧基、庚氧基、辛氧基或环己氧基，Rx 为例如 -NH2+CH2CH20H Cl-, -NH3+ -OAc, =NOH, -NHCH(CH3)COO-K+,- NHCH2CH2NH( )2+ -OAC, -NHCH2CH2SO3-K+, -NHCH(COO- K+)CH2CH2S , -NHCH2COO- K+, -OCH( )COO-K+, -OCH2CH2NH( )2+ -OAC, -OCH2CH2SO3-K+, -OCH(COO- K+)CH2CH2S 或 -OCH2COO-K+，R5 包括重复单元 -(OCH2CH2)-, -(OCH2CH2( ))-,-(CH2CHCOOH)-, -(CH2C( )COOH)-, -(CH2CHCOO )-, -(NHCH2CH2)-, -(CH2CHOH)-, -(CH2CHCONH2)- 或 -(CH2CH(NHCOH))-. 这些化合物在稳定水性聚合物体系抵抗氧化、热和光辐射的有害影响方面特别有效。这些化合物例如在稳定水性涂料、水性油墨、水性喷墨介质和光固化水性系统方面非常有效。
• Imidazo&lsqb;1,2-a&rsqb;pyridine compounds
  申请人：AstraZeneca AB

  公开号：US06613775B1

  公开（公告）日：2003-09-02

  The present invention relates to novel compounds, and therapeutically acceptable salts thereof of the formula (I), which inhibit exogenously or endogenously stimulated gastric acid secretion and thus can be used in the prevention and treatment of gastrointestinal inflammatory diseases.

  本发明涉及新型化合物及其具有治疗可接受性的公式(I)盐，这些化合物能够抑制外源性或内源性刺激引起的胃酸分泌，因此可用于预防和治疗胃肠道炎症性疾病。
• Method for the treatment of CNS disorders with substituted 2-imidazoles or imidazole derivatives
  申请人：Galley Guido

  公开号：US20070197621A1

  公开（公告）日：2007-08-23

  The present invention relates a method for treating depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders which comprises administering to an individual a therapeutically effective amount of a compound of formula I wherein R, R 1 , R 2 , A and n are as defined in the specification and to their pharmaceutically active salts. The invention also relates to novel compounds of formula I, pharmaceutical compositions containing them, and methods for their preparation.

  本发明涉及一种治疗抑郁症、焦虑症、双相情感障碍、注意力缺陷多动障碍、压力相关障碍、精神分裂症等精神障碍、帕金森病等神经系统疾病、阿尔茨海默病等神经退行性疾病、癫痫、偏头痛、高血压、物质滥用、进食障碍、糖尿病、糖尿病并发症、肥胖症、血脂异常、能量消耗和吸收障碍、体温稳态障碍、睡眠和昼夜节律障碍以及心血管疾病的方法，包括向个体施用化合物I的治疗有效量，其中R、R1、R2、A和n如规范中所定义，以及其药用活性盐。该发明还涉及化合物I的新颖化合物、含有它们的药物组合物以及它们的制备方法。
• Substituted hexahydro-1,4-diazepin-5-ones and compositions stabilized therewith
  申请人：Wood Mervin G.

  公开号：US20070256352A1

  公开（公告）日：2007-11-08

  The instant invention pertains to white, dyed, dipped, unscented and/or scented candle wax which is effectively stabilized against discoloration and fading by the incorporation therein of a substituted hexahydro-1,4-diazepin-5-ones in combination with a UV absorber and/or an antioxidant. Additionally, some novel substituted hexahydro-1,4-diazepin-5-one compounds are described.

  本发明涉及白色、染色、浸渍、无香味和/或有香味的蜡烛蜡，通过在其中加入取代的六氢-1,4-二氮杂环-5-酮与紫外线吸收剂和/或抗氧化剂的组合，有效地稳定防止褪色和退色。此外，还描述了一些新颖的取代的六氢-1,4-二氮杂环-5-酮化合物。
• Compounds for inhibition of gastric acid secretion
  申请人：AstraZeneca AB

  公开号：US06265415B1

  公开（公告）日：2001-07-24

  The present invention relates to imidazo pyridine derivatives of the formula (I), in which the phenyl moiety is substituted with lower alkyl in 2- and 6-position, which inhibit exogenously or endogenously stimulated gastric acid secretion and thus can be used in the prevention and treatment of gastrointestinal inflammatory diseases.

  本发明涉及式(I)的咪唑吡啶衍生物，其中苯基部分在2-和6-位置被较低的烷基取代，它们抑制外源性或内源性刺激的胃酸分泌，因此可用于预防和治疗胃肠道炎症性疾病。