2-乙基-丁酸钙盐(2:1) | 136-91-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2-乙基-丁酸钙盐(2:1)
• 中文别名: 二(2-乙基丁酸)钙
• CAS: 136-91-4
• 化学式: C6H12CaO2
• 分子量: 156.24
• InChiKey: GDBLYPODLXAJGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.13
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] NITRIC OXIDE RELEASING PRODRUGS OF THERAPEUTIC AGENTS<br/>[FR] PROMÉDICAMENTS D'AGENTS THÉRAPEUTIQUES LIBÉRANT DE L'OXYDE NITRIQUE
  申请人：SATYAM APPARAO

  公开号：WO2014111957A1

  公开（公告）日：2014-07-24

  The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents wherein the drug or therapeutic agents contain at least one carboxylic acid group. The invention also relates to processes for the preparation of these nitric oxide releasing prodrugs, to pharmaceutical compositions containing them and to methods of using these prodrugs.

  本发明涉及已知药物或治疗剂的一氧化氮释放前药，其中所述药物或治疗剂至少含有一个羧酸基团。发明还涉及制备这些一氧化氮释放前药的方法，包含它们的药物组合物以及使用这些前药的方法。
• Nitric Oxide Releasing Prodrugs of Therapeutic Agents
  申请人：SATYAM Apparao

  公开号：US20110263526A1

  公开（公告）日：2011-10-27

  The present invention relates to nitric oxide releasing prodrugs of known drugs or therapeutic agents which are represented herein as compounds of formula (I) wherein the drugs or therapeutic agents contain one or more functional groups independently selected from a carboxylic acid, an amino, a hydroxyl and a sulfhydryl group. The invention also relates to processes for the preparation of the nitric oxide releasing prodrugs (the compounds of formula (I)), to pharmaceutical compositions containing them and to methods of using the prodrugs.

  本发明涉及已知药物或治疗剂的一氧化氮释放前药，其在此处表示为式(I)的化合物，其中药物或治疗剂包含一个或多个功能基团，独立地选自羧酸、氨基、羟基和巯基。该发明还涉及制备一氧化氮释放前药（式(I)的化合物）的方法，含有它们的药物组合物以及使用这些前药的方法。
• Technology for the Preparation of Microparticles
  申请人：Malakhov Michael

  公开号：US20090098207A1

  公开（公告）日：2009-04-16

  Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.

  微球是通过将溶液中的大分子或小分子与抗溶剂和对离子接触，并冷却溶液而制备的。这些微球可用于制备具有明确定义尺寸的药物、营养保健品、化妆品等产品。
• Compositions and methods to effect the release profile in the transdermal administration of active agents
  申请人：——

  公开号：US20020004065A1

  公开（公告）日：2002-01-10

  Compositions and methods for the transdermal delivery of active agents up to a period of seven days or more at substantially a zero-order release rate comprising a pharmaceutically acceptable adhesive matrix and a polymeric plastic material that provides a release rate regulating effect on the active agents.

  本发明涉及一种用于经皮递送活性药剂的组合物和方法，该组合物和方法能够在持续时间为七天或更长时间内以几乎零阶释放速率递送活性药剂，包括一种药学上可接受的粘合基质和一种聚合物塑料材料，该聚合物塑料材料对活性药剂具有释放速率调节作用。
• INTERLAYER FILM FOR LAMINATED GLASS, AND LAMINATED GLASS
  申请人：SEKISUI CHEMICAL CO., LTD.

  公开号：EP3909929A1

  公开（公告）日：2021-11-17

  An interlayer film for laminated glass of the present invention comprises a thermoplastic resin, a carboxylic acid, and an alkali (alkaline earth) metal, wherein, when a molar concentration per unit volume of the alkali (alkaline earth) metal in the interlayer film for laminated glass, measured by ICP atomic emission spectrophotometry is A (mol/m3); a molar concentration per unit volume of the carboxylic acid in the interlayer film for laminated glass, measured by GC-MS is B (mol/m3); a molar concentration per unit volume of the carboxylic acid in the interlayer film for laminated glass, measured by GC-MS after a hydrochloric acid aqueous solution is added to the interlayer film for laminated glass to be left at 23°C for 12 hours is Y; and a molar concentration per unit volume of the carboxylic acid, obtained by subtracting the molar concentration B from the concentration Y is D (mol/m3), the molar concentration A is more than 0.35 mol/m3 and less than 1.00 mol/m3, and a carboxylic acid isolation ratio (1) represented by (1 - D/A) × 100 is 40% or less.

  本发明的夹层玻璃用中间膜由热塑性树脂、羧酸和碱（碱土）金属组成，其中，当通过 ICP 原子发射分光光度法测量夹层玻璃用中间膜中碱（碱土）金属的摩尔浓度单位体积为 A（mol/m3）时；通过 GC-MS 测量夹层玻璃用中间膜中羧酸的摩尔浓度单位体积为 B（mol/m3）时；将盐酸水溶液加入夹层玻璃用中间膜并在 23°C 下放置 12 小时后，用 GC-MS 测得的夹层玻璃用中间膜中羧酸的摩尔浓度为 Y；从浓度 Y 中减去摩尔浓度 B 得到的羧酸的摩尔浓度为 D（mol/m3），摩尔浓度 A 大于 0.35摩尔/立方米且小于1.00摩尔/立方米，羧酸分离率（1）由（1-D/A）×100表示，等于或小于40%。