5-methyldecanoic acid | 75854-70-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5-methyldecanoic acid
• 英文别名: 5-methyl-decanoic acid；5-Methyl-decansaeure；(+/-)-5-Methyl-decansaeure-(1)；5-Methyl-decansaeure-(1)
• CAS: 75854-70-5
• 化学式: C₁₁H₂₂O₂
• 分子量: 186.294
• InChiKey: BDUUYZWYAVGTOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-methyldecanoic acid 、 甲基锂 在 乙醚 作用下， 生成 6-methyl-undecan-2-one
  参考文献：
  名称：

  318.多烯系列研究。第XLVI部分。维生素A酸的邻甲苯基和间苯二酚类似物的合成

  摘要：

  DOI：

  10.1039/jr9530001571
• 作为产物：
  描述：

  2-甲基-1-庚醇 在 四氯化碳 、 sodium hydroxide 、 三苯基膦 作用下， 以 1,4-二氧六环 、 甲醇 为溶剂， 反应 4.0h， 生成 5-methyldecanoic acid
  参考文献：
  名称：

  Do enzymes recognise remotely located stereocentres? Highly enantioselective Candida rugosa lipase-catalysed esterification of the 2- to 8-methyldecanoic acids

  摘要：

  Several racemic methyl decanoic acids have been synthesised and Successfully resolved in esterification with 1-hexadecanol at a(w)=0.8 in cyclohexane using immobilised Candida rugosa lipase (CRL) as the catalyst. The enantiomeric ratios (E=2.8-68) obtained were surprisingly high even when the methyl group was as remotely located as in 8-methyldecanoic acid (E=25). Interestingly, the lipase shows enantiopreference for the S-enantiomer when the methyl group is located on even numbered carbons i.e. for the 2-,4-,6- and 8-methyldecanoic acids and to the R-enantiomer when the methyl group is located on uneven numbered carbons i.e. for the 3-,5- and 7-methyldecanoic acids. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(02)00172-6

文献信息

• [EN] SUBSTITUTED SULFONAMIDE DERIVATIVES<br/>[FR] DÉRIVÉS SUBSTITUÉS DE SULFONAMIDE
  申请人：GRUENENTHAL GMBH

  公开号：WO2009124746A1

  公开（公告）日：2009-10-15

  The invention relates to substituted sulfonamide derivatives, processes for the preparation thereof, medicaments containing these compounds and the use of substituted sulfonamide derivatives for the preparation of medicaments.

  这项发明涉及替代磺胺基衍生物，其制备方法，含有这些化合物的药物以及利用替代磺胺基衍生物制备药物。
• Oil-based cosmetic preparation
  申请人：Gotou Naoki

  公开号：US20060051307A1

  公开（公告）日：2006-03-09

  An oil-based cosmetic preparation contains (a) an oily gelling agent, (b) an oil-based ingredient, and (c) at least one selected from the group consisting of ester compounds represented by formula (I) which are reaction products of ditrimethylolpropane with fatty acid, polycondensates of ditrimethylolpropane with polycarboxylic acid, polycondensates of the ester compound of formula (I) with polycarboxylic acid, polycondensates of fatty acid with the polycondensate of ditrimethylolpropane with polycarboxylic acid, and polycondensates of ditrimethylolpropane, fatty acid and polycarboxylic acid, with the component (c) having a hydroxyl value (OHV) in the range of 10 to 150. The oil-based cosmetic preparation has excellent feeling realized by the use, provides a make-up coverage with satisfactory luster and moisturizing feel, and exhibits excellent shape retention properties.

  一种油基化妆品制剂包含(a)一种油性凝胶剂，(b)一种油性成分，以及(c)至少从由式(I)表示的酯化合物组成的群体中选择的一种，该酯化合物是二三甲基丙烷与脂肪酸的反应产物，二三甲基丙烷与多羧酸的聚缩物，式(I)的酯化合物与多羧酸的聚缩物，脂肪酸与二三甲基丙烷与多羧酸的聚缩物的酯化合物的聚缩物，以及二三甲基丙烷、脂肪酸和多羧酸的聚缩物，其中组分(c)具有羟值（OHV）在10至150之间。该油基化妆品制剂具有优异的感觉，提供具有令人满意的光泽和保湿感的化妆覆盖，并表现出优异的保形性能。
• [EN] PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF<br/>[FR] PROMEDICAMENTS D'ANALOGUES DE GABA, COMPOSITIONS ET UTILISATIONS DESDITS PROMEDICAMENTS
  申请人：XENOPORT INC

  公开号：WO2002100347A2

  公开（公告）日：2002-12-19

  The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using phannaceutical compositions of prodrugs of GABA analogs for treating or preventing common diseases and/or disorders.

  本发明提供了GABA类似物的前药，前药的制药组合物以及制备GABA类似物前药的方法。本发明还提供了使用GABA类似物前药的方法以及使用前药的制药组合物治疗或预防常见疾病和/或疾病的方法。
• Refrigerating machine oil composition and compressor using the same
  申请人：MITSUBISHI DENKI KABUSHIKI KAISHA

  公开号：EP0714973A1

  公开（公告）日：1996-06-05

  A refrigerating machine oil composition suitable for a compressor using a hydrofluorocarbon as a refrigerant, which comprises 100 parts by weight of a polyol ester as a base oil, from 7.0 to 15.0 parts by weight of a phosphate, and from 0.2 to 3.0 parts by weight in total of a 1,2-epoxy-alkane and/or a vinylcyclohexene dioxide. The use of the refrigerating machine oil composition improves wear resistance of sliding portions of compressors and is free from the formation of sludges derived from the polyol ester used as a base oil of the oil composition. A rotary compressor using the oil composition is also disclosed.

  一种适用于使用氢氟碳化合物作为制冷剂的压缩机的冷冻机油组合物，它包括 100 重量份作为基础油的多元醇酯、7.0 至 15.0 重量份的磷酸盐和 0.2 至 3.0 重量份的 1,2-环氧烷和/或乙烯基环己烯二氧化物。使用该冷冻机油组合物可以提高压缩机滑动部分的耐磨性，并且不会形成由用作油组合物基础油的多元醇酯产生的油泥。此外，还公开了一种使用该油组合物的旋转式压缩机。
• Anhydrous ultraviolet light screening composition containing octocrylene
  申请人：SCHERING-PLOUGH HEALTHCARE PRODUCTS, INC.

  公开号：EP1060735A1

  公开（公告）日：2000-12-20

  The invention relates to anhydrous compositions that are useful as UV-light screens for mammalian skin. Such compositions comprise octocrylene, octyldodecyl neopentanoate, and a C1-C4 alcohol vehicle. The invention also relates to methods of inhibiting or preventing UV light-induced skin damage by administering an effective amount of such a composition to the skin of a mammal in need of such inhibition or protection.

  本发明涉及可用作哺乳动物皮肤紫外线防护屏的无水组合物。这种组合物由辛丙烯、新戊酸辛基十二烷基酯和 C1-C4 醇载体组成。本发明还涉及通过向需要抑制或保护的哺乳动物皮肤施用有效量的此类组合物来抑制或预防紫外线引起的皮肤损伤的方法。