2-bromo-N-[4-(4-fluorophenoxy)phenyl]acetamide | 36160-89-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-bromo-N-[4-(4-fluorophenoxy)phenyl]acetamide
• CAS: 36160-89-1
• 化学式: C₁₄H₁₁BrFNO₂
• 分子量: 324.149
• InChiKey: AFVMHLSRAMVXOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-bromo-N-[4-(4-fluorophenoxy)phenyl]acetamide 、 3-(N-Boc-N-甲氨基)丙胺 在 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A4 hydrolase

  摘要：

  The synthesis and biological evaluation of a series of N-alkyl glycine amide analogs as LTA(4)-h inhibitors and the importance of the introduction of a benzoic acid group to the potency and pharmacokinetic parameters of our analogs are described. The lead compound in the series, 4q, has excellent potency and oral bioavailability. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.06.046
• 作为产物：
  描述：

  4-(4-氟苯氧基)苯胺 、 溴乙酰溴 在 N,N-二乙基苯胺 作用下， 以 二氯甲烷 为溶剂， 生成 2-bromo-N-[4-(4-fluorophenoxy)phenyl]acetamide
  参考文献：
  名称：

  Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A4 hydrolase

  摘要：

  The synthesis and biological evaluation of a series of N-alkyl glycine amide analogs as LTA(4)-h inhibitors and the importance of the introduction of a benzoic acid group to the potency and pharmacokinetic parameters of our analogs are described. The lead compound in the series, 4q, has excellent potency and oral bioavailability. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.06.046

文献信息

• Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A4 hydrolase
  作者：Bin Ye、John Bauman、Ming Chen、David Davey、Seock-Kyu Khim、Beverly King、Thomas Kirkland、Monica Kochanny、Amy Liang、Dao Lentz、Karen May、Lisa Mendoza、Gary Phillips、Victor Selchau、Sabine Schlyer、Jih-Lie Tseng、Robert G. Wei、Hong Ye、John Parkinson、William J. Guilford

  DOI：10.1016/j.bmcl.2008.06.046

  日期：2008.7

  The synthesis and biological evaluation of a series of N-alkyl glycine amide analogs as LTA(4)-h inhibitors and the importance of the introduction of a benzoic acid group to the potency and pharmacokinetic parameters of our analogs are described. The lead compound in the series, 4q, has excellent potency and oral bioavailability. (C) 2008 Elsevier Ltd. All rights reserved.