1-Thiophen-2-yl-3-thiophen-3-ylprop-2-yn-1-ol | 1200715-87-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 1-Thiophen-2-yl-3-thiophen-3-ylprop-2-yn-1-ol
• CAS: 1200715-87-2
• 化学式: C₁₁H₈OS₂
• 分子量: 220.316
• InChiKey: QQRLZYIGNXKCJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  76.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-Thiophen-2-yl-3-thiophen-3-ylprop-2-yn-1-ol 、 苄脒盐酸盐 在 barium manganate 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 0.75h， 以86%的产率得到2-Phenyl-4-thiophen-2-yl-6-thiophen-3-ylpyrimidine
  参考文献：
  名称：

  Barium manganate in microwave-assisted oxidation reactions: synthesis of solvatochromic 2,4,6-triarylpyrimidines

  摘要：

  Synthesis of 2,4,6-trisubstituted pyrimidines by tandem oxidation/heterocyclocondensation of propargylic alcohols and amidines is effected rapidly and efficiently under microwave dielectric heating using barium manganate as oxidant. Irradiation at 150 degrees C in ethanol-acetic acid for 45 min results in dramatic improvements in yield over the corresponding manganese dioxide-mediated method and establishes a rapid route to triarylpyrimidines in order to investigate their photophysical properties. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.09.116

文献信息

• Barium manganate in microwave-assisted oxidation reactions: synthesis of solvatochromic 2,4,6-triarylpyrimidines
  作者：Mark C. Bagley、Zhifan Lin、Simon J.A. Pope

  DOI：10.1016/j.tetlet.2009.09.116

  日期：2009.12

  Synthesis of 2,4,6-trisubstituted pyrimidines by tandem oxidation/heterocyclocondensation of propargylic alcohols and amidines is effected rapidly and efficiently under microwave dielectric heating using barium manganate as oxidant. Irradiation at 150 degrees C in ethanol-acetic acid for 45 min results in dramatic improvements in yield over the corresponding manganese dioxide-mediated method and establishes a rapid route to triarylpyrimidines in order to investigate their photophysical properties. (C) 2009 Elsevier Ltd. All rights reserved.