2-乙基庚基甲酸酯 | 94200-06-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-乙基庚基甲酸酯
• 中文别名: 2-(3-碘丙-2-炔-1-氧基)乙基苯基氨基甲酸酯
• 英文名称: 2-Ethylheptyl formate
• CAS: 94200-06-3
• 化学式: C₁₀H₂₀O₂
• 分子量: 172.26
• InChiKey: RKHIJTPJWVVCHK-UHFFFAOYSA-N

物化性质

• 熔点：
  -34.1°C (estimate)
• 沸点：
  202.6°C (estimate)
• 密度：
  0.8771 (estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use
  申请人：Sankyo Company Limited

  公开号：EP0536936A1

  公开（公告）日：1993-04-14

  Compounds of formula (I): [in which: R¹, R² and R³ are the same or different and each represents a hydrogen atom, an optionally substituted alkanoyl group or an alkenylcarbonyl group, provided that at least one of R¹, R² and R³ represents an unsubstituted alkanoyl group having from 5 to 24 carbon atoms, said substituted alkanoyl group or said alkenylcarbonyl group; and one of R⁴ and R⁵ represents a hydrogen atom and the other represents a cyano group]; have valuable anti-tumour activity.

  式子（I）的化合物：[其中：R¹、R²和R³相同或不同，每个代表氢原子、可选取代的脂肪酰基团或烯基羰基团，前提是至少有一个R¹、R²和R³代表有5到24个碳原子的未取代脂肪酰基团，或者是所述取代的脂肪酰基团或所述烯基羰基团；R⁴和R⁵中的一个代表氢原子，另一个代表氰基]，具有有价值的抗肿瘤活性。
• 2'-Cyanopyrimidine Nucleoside Compound
  申请人：Dohi Suguru

  公开号：US20100056466A1

  公开（公告）日：2010-03-04

  The present invention provides a pyrimidine nucleoside compound represented by the following formula (1): [wherein one of X and Y is cyano and the other is hydrogen; and i) R 1 is hydrogen, and R 2 is alkyloxycarbonyl wherein the alkyl moiety is straight or branched C 5-12 alkyl (the alkyl may be substituted), or alternatively, ii) R 1 is alkyloxycarbonyl wherein the alkyl moiety is straight or branched C 9 alkyl or alkenyloxycarbonyl wherein the alkenyl moiety is straight or branched C 9 alkenyl, and R 2 is hydrogen] or a salt thereof. The pyrimidine nucleoside compound or a salt thereof of the present invention shows a higher antitumor effect than existing pyrimidine nucleoside compounds.

  本发明提供了一种嘧啶核苷化合物，其由以下式子（1）表示：[其中X和Y中的一个是氰基，另一个是氢原子；i）R1为氢原子，R2为烷氧羰基，其中烷基是直链或支链C5-12烷基（烷基可以被取代），或者，ii）R1为烷氧羰基，其中烷基是直链或支链C9烷基或烯基氧羰基，其中烯基是直链或支链C9烯基，R2为氢原子]或其盐。本发明的嘧啶核苷化合物或其盐比现有的嘧啶核苷化合物具有更高的抗肿瘤效果。
• 2'-CYANOPYRIMIDINE NUCLEOSIDE COMPOUND
  申请人：DOHI Suguru

  公开号：US20100216736A2

  公开（公告）日：2010-08-26

  The present invention provides a pyrimidine nucleoside compound represented by the following formula (1): [wherein one of X and Y is cyano and the other is hydrogen; and i) R 1 is hydrogen, and R 2 is alkyloxycarbonyl wherein the alkyl moiety is straight or branched C 5-12 alkyl (the alkyl may be substituted), or alternatively, ii) R 1 is alkyloxycarbonyl wherein the alkyl moiety is straight or branched C 9 alkyl or alkenyloxycarbonyl wherein the alkenyl moiety is straight or branched C 9 alkenyl, and R 2 is hydrogen] or a salt thereof. The pyrimidine nucleoside compound or a salt thereof of the present invention shows a higher antitumor effect than existing pyrimidine nucleoside compounds.

  本发明提供了一种由以下式（1）表示的嘧啶核苷化合物：[其中X和Y中的一个是氰基，另一个是氢；i）R1是氢，R2是烷氧羰基，其中烷基是直链或支链C5-12烷基（烷基可以被取代），或者，ii）R1是烷氧羰基，其中烷基是直链或支链C9烷基或烯基氧羰基，其中烯基是直链或支链C9烯基，而R2是氢]或其盐。本发明的嘧啶核苷化合物或其盐比现有的嘧啶核苷化合物具有更高的抗肿瘤效果。
• Rubber composition and pneumatic tire
  申请人：TOYO TIRE & RUBBER CO., LTD.

  公开号：US10723866B2

  公开（公告）日：2020-07-28

  A rubber composition according to an embodiment includes: a rubber component comprising diene rubber; and fine particles which are formed of a specific polymer and have a glass transition point of −70° C. to 0° C. The fine particles are fine particles formed of a (meth)acrylate polymer having a constitutional unit represented by formula (1) or formed of a polymer having a constitutional unit represented by formula (4). In formula (1), R1 represents a hydrogen atom or a methyl group, and R2 represents an alkyl group having 4 to 18 carbon atoms. In formula (4), at least one of R11, R12, R13, R14, R15, and R16 represents an aliphatic hydrocarbon group having 3 to 8 carbon atoms, and the remainder represents a hydrogen atom or an aliphatic hydrocarbon group having 1 or 2 carbon atoms.

  根据一个实施例的橡胶组合物包括：由二烯橡胶组成的橡胶组分；以及由特定聚合物形成且玻璃化转变点为-70℃至0℃的细颗粒。细颗粒是由具有式（1）表示的组成单元的（甲基）丙烯酸酯聚合物形成的细颗粒，或由具有式（4）表示的组成单元的聚合物形成的细颗粒。在式 (1) 中，R1 代表氢原子或甲基，R2 代表具有 4 至 18 个碳原子的烷基。在式 (4) 中，R11、R12、R13、R14、R15 和 R16 中至少有一个代表具有 3 至 8 个碳原子的脂族烃基，其余代表氢原子或具有 1 或 2 个碳原子的脂族烃基。
• RUBBER COMPOSITION AND PNEUMATIC TIRE
  申请人：TOYO TIRE & RUBBER CO., LTD.

  公开号：US20180346694A1

  公开（公告）日：2018-12-06

  A rubber composition according to an embodiment includes: a rubber component comprising diene rubber; and fine particles which are formed of a specific polymer and have a glass transition point of −70° C. to 0° C. The fine particles are fine particles formed of a (meth)acrylate polymer having a constitutional unit represented by formula (1) or formed of a polymer having a constitutional unit represented by formula (4). In formula (1), R 1 represents a hydrogen atom or a methyl group, and R 2 represents an alkyl group having 4 to 18 carbon atoms. In formula (4), at least one of R 11 , R 12 , R 13 , R 14 , R 15 , and R 16 represents an aliphatic hydrocarbon group having 3 to 8 carbon atoms, and the remainder represents a hydrogen atom or an aliphatic hydrocarbon group having 1 or 2 carbon atoms.