2-乙氧基-3,4,5,6-四氢吡啶 | 15200-13-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-乙氧基-3,4,5,6-四氢吡啶
• 英文名称: 6-ethoxy-2,3,4,5-tetrahydro-pyridine
• 英文别名: 2-ethoxy-3,4,5,6-tetrahydropyridine；Methoxy-6 tetrahydro-2,3,4,5 pyridine；6-Ethoxy-2,3,4,5-tetrahydropyridine；6-Aethoxy-2,3,4,5-tetrahydro-pyridin；2-Aethoxy-3,4,5,6-tetrahydro-pyridin
• CAS: 15200-13-2
• 化学式: C₇H₁₃NO
• 分子量: 127.186
• InChiKey: WOZDKJXZGHBIPP-UHFFFAOYSA-N

物化性质

• 沸点：
  161-165 °C
• 密度：
  1.00±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2933399090
• 包装等级：
  III
• 危险类别：
  3
• 危险性防范说明：
  P210,P240,P241,P242,P243,P261,P271,P280,P302+P352,P303+P361+P353,P304+P340,P305+P351+P338,P312,P332+P313,P337+P313,P362,P370+P378,P403+P233,P403+P235,P405,P501
• 危险品运输编号：
  1993
• 危险性描述：
  H225,H315,H319,H335
• 储存条件：
  室温

反应信息

• 作为反应物：
  描述：

  2-乙氧基-3,4,5,6-四氢吡啶 以 甲醇 为溶剂， 反应 17.0h， 生成 2-ethylidene-5,6,7,8-tetrahydro-imidazo<1,2-a>pyridine-3-one
  参考文献：
  名称：

  Novel Derivatives of Biogenic ?-Aminoacids by ring transformations with lactam derivatives

  摘要：

  Binucleophilic biogenic alpha-aminoacids 1 such as cysteine, penicillamine, serine, and threonine react with lactam acetals 2 by condensation to bridged alpha-amidinoacids 3 or by condensation/ring transformation to 2-(omega-aminoalkyl)-1,3-azoline-4-carboxylic acids 6. Corresponding reactions with lactim ethers 7 afford analogous alpha-amidinoacids 8, condensed imidazolones 10 as their derivatives, omega-aminoalkyl-1,3-azolines 13 and, by further reaction with lactim ether 7, modified omega-amidinoalkyl-1,3-azolines 14.

  DOI：

  10.1002/prac.199533701117
• 作为产物：
  描述：

  环戊酮肟 在 吡啶 、 对甲苯磺酰氯 作用下， 生成 2-乙氧基-3,4,5,6-四氢吡啶
  参考文献：
  名称：

  DE532969

  摘要：

  公开号：

文献信息

• Modular Routes Towards New N,O-Bidentate Ligands Containing an Electronically Delocalised β-Enaminone Chelating Backbone
  作者：Udo Beckmann、Eva Eichberger、Monika Lindner、Melanie Bongartz、Peter C. Kunz

  DOI：10.1002/ejoc.200800372

  日期：2008.8

  Nickel complexes with N,O-chelating ligands turned out to be promising catalysts in that field. In this work a series of new N,O ligands with an electronically delocalised β-enaminone backbone were synthesised and fully characterised. The ligand design was inspired by the ligand found in the most efficient nickel catalyst for polyketone synthesis and developed to a highly modular LEGO®-like arsenal of

  聚酮是通过过渡金属催化的烯烃和一氧化碳的共聚反应合成的。镍与 N,O 螯合配体的配合物被证明是该领域有前途的催化剂。在这项工作中，合成并充分表征了一系列具有电子离域 β-烯胺酮骨架的新 N,O 配体。配体设计的灵感来自于最有效的聚酮合成镍催化剂中发现的配体，并开发为高度模块化的 LEGO® 类反应库，用于多功能取代的 β-烯胺酮配体。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
• Novel heterocycles.<b>6</b>. The condensation of ethyl<i>o</i>-fluorobenzoyl acetate with cyclic imino ethers
  作者：Gary M. Coppola、Robert E. Damon

  DOI：10.1002/jhet.5570170818

  日期：1980.12

  The reaction between ethyl o-fluorobenzoylacetate and cyclic imino ethers is described. The products, the corresponding 1,2-fused quinolines (13a-17a), were isolated in good yields. In one instance the uncyclized condensation intermediate 18 was isolated and characterized.

  描述了邻氟苯甲酰基乙酸乙酯和环状亚氨基醚之间的反应。产物，相应的1,2-稠合喹啉（13a-17a），以良好的产率分离。在一个实例中，未环化的缩合中间体18被分离并表征。
• Quinolizidines. XXV. An extension of the "lactim ether route" to the racemic syntheses of several indolo[2,3-a]quinolizidine alkaloids.
  作者：TOZO FUJII、SHIGEYUKI YOSHIFUJI、HARUE ITO

  DOI：10.1248/cpb.36.3348

  日期：——

  The "lactim ether route, " originally designed for unified racemic and chiral syntheses of the benzo[a]quinolizidine-type Alangium alkaloids, has been extended to cover the racemic syntheses of several indolo[2, 3-a]quinolizidine alkaloids (1 and 8c, d). The synthetic routes started from the lactams 5a, b and proceeded smoothly through the lactim ethers 6a, b, lactam ketones 7a, b, lactam alcohols 10a, b, and N-substituted lactams 9a, b.

  内酰胺醚路线 "最初是为苯并[a]喹嗪类阿兰生物碱的统一外消旋和手性合成而设计的，现已扩展到几种吲哚并[2, 3-a]喹嗪类生物碱（1 和 8c、d）的外消旋合成。合成路线从内酰胺 5a, b 开始，通过内酰胺醚 6a, b、内酰胺酮 7a, b、内酰胺醇 10a, b 和 N-取代内酰胺 9a, b 顺利进行。
• [EN] HYDROFLUOROCABOXIMIDATE AND METHODS OF MAKING AND USING THE SAME<br/>[FR] HYDROFLUOROCABOXIMIDATE, PROCÉDÉS DE FABRICATION ET D'UTILISATION ASSOCIÉS
  申请人：3M INNOVATIVE PROPERTIES CO

  公开号：WO2019067113A1

  公开（公告）日：2019-04-04

  Described herein is an hydrofluorocarboximidate of formula (I) where: RH is a linear or branched alkyl group comprising 1 or 2 carbon atoms and (a) Rf1 and Rf2 are independently selected from a linear or branched perfluorinated alkyl group comprising 1-8 carbon atoms and optionally comprising at least one catenated atom selected from oxygen, nitrogen, or combinations thereof; or (b) Rf1 and Rf2 are connected to form a ring structure comprising a total of 4-8 carbon atoms and in addition to the nitrogen atom from the carboximidate the ring structure may optionally comprises at least one catenated atom selected from oxygen, nitrogen, or combinations thereof. A method of making the hydrofluorocarboximidate with improved yield is described as well as various uses for the hydrofluorocarboximidate of Formula (I).

  本文描述了一种化学式（I）的氢氟羧酰胺，其中：RH是由1或2个碳原子组成的直链或支链烷基基团，（a）Rf1和Rf2分别选自由1-8个碳原子组成的直链或支链全氟烷基基团，并且可选地包含至少一个由氧、氮或两者组合选择的连接原子；或（b）Rf1和Rf2连接形成包含总共4-8个碳原子的环结构，除了来自羧酰胺的氮原子外，这个环结构还可以可选地包含至少一个由氧、氮或两者组合选择的连接原子。还描述了一种制备具有改进产率的氢氟羧酰胺的方法，以及化学式（I）的氢氟羧酰胺的各种用途。
• Total Synthesis of (±)Variotin and Its Analogs
  作者：Akihiko Ishida、Teruaki Mukaiyama

  DOI：10.1246/bcsj.51.2077

  日期：1978.7

  1-Sorboyl-2-pyrrolidone was prepared from sorbic acid and 2-ethoxy-1-pyrroline using 1-methyl-2-chloropyridinium iodide as a coupling reagent. Variotin and its analogs were similarly synthesized from lactim ethers and (2E,4E,6E)-8-hydroxy-2,4,6-dodecatrienoic acids without protecting the hydroxyl group at C-8. (2E,4E,6E)-8-Hydroxy-6-methyl-2,4,6-dodecatrienal, a precursor of trienoic acid, was synthesized by the elimination of methanol from (2E,6E)-8-acetoxy-5-methoxy-6-methyl-2,6-dodecadienal prepared from the reaction of 1-trimethylsiloxy-1,3-butadiene with (2E)-4-acetoxy-2-methyl-2-octenal dimethyl acetal.

  使用 1-甲基-2-氯吡啶鎓碘化物作为偶联试剂，从山梨酸和 2-乙氧基-1-吡咯啉制备出 1-山梨醇基-2-吡咯烷酮。变异素及其类似物同样也是由内脂醚和 (2E,4E,6E)-8-羟基-2,4,6-十二碳三烯酸合成的，但没有保护 C-8 处的羟基。(2E,4E,6E)-8-羟基-6-甲基-2,4,6-十二碳三烯醛是由 1-三甲基硅氧基-1,3-丁二烯与(2E)-4-乙酰氧基-2-甲基-2-辛烯醛二甲基缩醛反应制备的(2E,6E)-8-乙酰氧基-5-甲氧基-6-甲基-2,6-十二碳二烯醛通过消除甲醇合成的，而(2E,6E)-8-羟基-6-甲基-2,4,6-十二碳三烯醛是三烯酸的前体。