propane-1,2,2,3-tetracarboxylic acid | 52163-78-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: propane-1,2,2,3-tetracarboxylic acid
• 英文别名: Propan-1,2,2,3-tetracarbonsaeure；Zitronensaeure
• CAS: 52163-78-7
• 化学式: C₇H₈O₈
• 分子量: 220.136
• InChiKey: JXHDZGPVOXKUSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  149
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  propane-1,2,2,3-tetracarboxylic acid 生成 丙三羧酸 、 methylammonium carbonate
  参考文献：
  名称：

  Perkin; Pink, Journal of the Chemical Society, 1925, vol. 127, p. 194

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氢氧化钾 作用下， 生成 propane-1,2,2,3-tetracarboxylic acid
  参考文献：
  名称：

  Bischoff, Justus Liebigs Annalen der Chemie, 1882, vol. 214, p. 63,66

  摘要：

  DOI：

文献信息

• BIOCONJUGATES OF SYNTHETIC APELIN POLYPEPTIDES
  申请人：YUAN Jun

  公开号：US20150030594A1

  公开（公告）日：2015-01-29

  The invention provides a bioconjugates comprising a synthetic polypeptide of Formula I′ (SEQ ID NO: 1): or an amide, an ester or a salt thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12 and X13 are defined herein and a half-life extending moiety wherein the peptide and the half-life extending moiety are covalently linked or fuse, optionally via a linker. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the bioconjugates of the invention, and its therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了一种生物共轭物，包括公式I'（SEQ ID NO:1）的合成多肽或其酰胺、酯或盐，其中X1、X2、X3、X4、X5、X6、X7、X8、X9、X10、X11、X12和X13在此定义，并且具有半衰期延长基团，其中肽和半衰期延长基团通过连接剂或融合共价连接，可选地。这些多肽是APJ受体的激动剂。本发明还涉及一种制造该生物共轭物的方法，以及其治疗用途，例如治疗或预防急性失代偿性心力衰竭（ADHF）、慢性心力衰竭、肺动脉高压、心房颤动、Brugada综合征、室性心动过速、动脉粥样硬化、高血压、再狭窄、缺血性心血管疾病、心肌病、心脏纤维化、心律失常、水潴留、糖尿病（包括妊娠糖尿病）、肥胖症、外周动脉疾病、脑血管意外、短暂性脑缺血发作、创伤性脑损伤、肌萎缩性侧索硬化、烧伤（包括晒伤）和妊娠高血压。本发明还提供了药理活性剂的组合和制药组合物。
• COMPOSITION FOR FORMING LIQUID CRYSTAL ALIGNMENT FILM AND LIQUID CRYSTAL DISPLAY ELEMENT
  申请人：SOKI CORPORATION

  公开号：US20150056367A1

  公开（公告）日：2015-02-26

  The present invention, which enables to align a liquid crystal molecule, when no voltage is applied thereto, and also to control pretilt angle of the liquid crystal molecule, relates to a composition for a liquid crystal alignment film comprising components represented by the following (A) to (D): (A) a meta-phenylene diamine derivative represented by the general formula [1]; (B) a meta-phenylene diamine derivative represented by the general formula [2]; (C) a para-arylene diamine represented by the general formula [3]; (D) a tetracarboxylic acid represented by the general formula [4] or a tetracarboxylic acid anhydride represented by the general formula [4′]; (wherein R 1 represents an alkyl group having 1 to 6 carbon atoms or the like, R 2 represents an alkyl group having 8 to 20 carbon atoms or the like, t moieties of R a represent an alkyl group having 1 to 3 carbon atoms or the like, n represents an integer of 1 to 3, t represents an integer of 0 to 4, T represents an oxygen atom or the like, Y represents an amino group, and Z represents a tetravalent hydrocarbon group.).

  本发明涉及一种液晶取向膜组合物，包括以下（A）至（D）的组分，能够在不施加电压的情况下使液晶分子对齐，并控制液晶分子的预倾角：（A）由通式[1]表示的间苯二胺衍生物；（B）由通式[2]表示的间苯二胺衍生物；（C）由通式[3]表示的对芳二胺；（D）由通式[4]表示的四羧酸或由通式[4']表示的四羧酸酐；（其中，R1表示具有1至6个碳原子的烷基或类似物，R2表示具有8至20个碳原子的烷基或类似物，R的t个官能团表示具有1至3个碳原子的烷基或类似物，n表示1至3的整数，t表示0至4的整数，T表示氧原子或类似物，Y表示氨基，Z表示四价碳氢基团）。
• 2,2,6,6-Tetramethyl-4-piperidyl spiro aliphatic ethers as stabilizers for synthetic polymers
  申请人：ADEKA ARGUS CHEMICAL CO., Ltd.

  公开号：EP0045358A2

  公开（公告）日：1982-02-10

  2,2,6,6-Tetramethyl-4-piperidyl spiro aliphatic ethers are provided, useful as stabilizers for organic polymeric materials, and having the general formula: wherein: Y1 is A,, A2, A3, A4, A5, and A6 each are selected from the group consisting of hydrogen; alkyl and hydroxyalkyl having from one to about eighteen carbon atoms; cycloalkyl having from three to about eight carbon atoms; aryl having from about six to about eighteen carbon atoms; acyl having from one to about eighteen carbon atoms wherein R4 is selected from the group consisting of aliphatic having from one to about eighteen carbon atoms; cycloaliphatic having from three to about eight carbon atoms; heterocyclic having from six to about eighteen carbon atoms; and aromatic having from six to about eighteen carbon atoms; carbamoyl wherein R5 is selected from the group consisting of aliphatic having from one to about eighteen carbon atoms; cycloaliphatic having from three to about eight carbon atoms; heterocylic having from six to about eighteen carbon atoms; and aromatic having from six to about eighteen carbon atoms; and monovalent oxyacid groups; at least one pair of A, and A2; A3 and A4; and A5 and A6 being taken together to form the group; wherein: Z is selected from the group consisting of hydrogen; oxyl 0; alkyl and hydroxyalkyl having from one to about twenty carbon atoms; and aryl and hydroxyaryl having from six to about twenty carbon atoms; X is selected from the group consisting of alkylene having from one to about eighteen carbon atoms; cycloalkylene having from three to about eight carbon atoms; arylene having from about six to about eighteen carbon atoms; polyacyl R4 wherein R4 is as above and n, is a number from 2 to 4; polycarbamoyl R5 wherein R5 is as above and n2 is a number from 2 to 4; and di- and trivalent oxyacid groups; R, and R2 each are selected from the group consisting of hydrogen; alkyl having from one to about eighteen carbon atoms; cycloalkyl having from three to about eight carbon atoms; aryl having from about six to about eighteen carbon atoms; carbamoyl wherein R5 is selected from the group consisting of aliphatic having from one to about eighteen carbon atoms; cycloaliphatic having from three to about eight carbon atoms; heterocyclic having from six to about eighteen carbon atoms; and aromatic having from six to about eighteen carbon atoms; and monovalent oxyacid groups; R3 is selected from the group consisting of alkyl having from one to about eighteen carbon atoms; cycloalkyl having from three to about eight carbon atoms; aryl having from about six to about eighteen carbon atoms; and -X-O-R1; R7 is selected from the group consisting of the residues of monohydric alcohols having from one to about eighteen carbon atoms and phenols having from six to about fifty carbon atoms; R" is selected from the group consisting of alkylene and oxyalkylene having from two to about ten carbon atoms and from zero to about five oxyether groups; cycloalkylene having from three to about eight carbon atoms; and arylene having from six to about fifty carbon atoms; and isocyanurate; m is a number from zero to 10; and p is zero or 1.

  本发明提供了 2,2,6,6-四甲基-4-哌啶基脂肪族螺醚，可用作有机聚合物材料的稳定剂，其通式为 其中Y1 是 A、A2、A3、A4、A5 和 A6 各选自氢；具有 1 至约 18 个碳原子的烷基和羟烷基；具有 3 至约 8 个碳原子的环烷基；具有约 6 至约 18 个碳原子的芳基；具有 1 至约 18 个碳原子的酰基组成的组 其中 R4 选自由 1 至约 18 个碳原子的脂肪族、3 至约 8 个碳原子的环脂族、6 至约 18 个碳原子的杂环族和 6 至约 18 个碳原子的芳香族组成的组； 氨基甲酰基 其中 R5 选自由 1 至约 18 个碳原子的脂肪族、3 至约 8 个碳原子的环脂族、6 至约 18 个碳原子的杂环族和 6 至约 18 个碳原子的芳香族组成的组； 和单价氧酸基团；至少有一对 A 和 A2、A3 和 A4 以及 A5 和 A6 共同组成该基团； 其中 Z 选自由氢、氧 0、具有 1 至约 20 个碳原子的烷基和羟基烷基以及具有 6 至约 20 个碳原子的芳基和羟基芳基组成的组； X 选自由 1 至约 18 个碳原子的亚烷基、3 至约 8 个碳原子的环亚烷基、约 6 至约 18 个碳原子的芳基、多酰基 R4 所组成的组。 其中 R4 如上，n 为 2 至 4 的数字； 聚氨基甲酰基 R5 其中 R5 如上，n2 为 2 至 4 的数字； 二价和三价氧酸基团； R和R2各自选自由下列物质组成的组：氢；具有 1 至约 18 个碳原子的烷基；具有 3 至约 8 个碳原子的环烷基；具有约 6 至约 18 个碳原子的芳基；氨基甲酰基 其中 R5 选自由 1 至约 18 个碳原子的脂肪族、3 至约 8 个碳原子的环脂族、6 至约 18 个碳原子的杂环族和 6 至约 18 个碳原子的芳香族组成的组； 以及单价氧酸基团； R3 选自由 1 至约 18 个碳原子的烷基、3 至约 8 个碳原子的环烷基、约 6 至约 18 个碳原子的芳基和-X-O-R1 组成的组； R7 选自具有 1 至约 18 个碳原子的一元醇残基和具有 6 至约 50 个碳原子的酚残基组成的组； R "选自由 2 至约 10 个碳原子和 0 至约 5 个氧醚基团的亚烷基和氧烷基、3 至约 8 个碳原子的环亚烷基和 6 至约 50 个碳原子的芳基组成的组；以及异氰尿酸酯； m 是零至 10 的数字；以及 p 为 0 或 1。
• Spiro[2,2,6,6-tetramethyl-piperidine-4,2'-(1',3'-dioxo(ol)an]-derivatives and stabilizers for synthetic polymers
  申请人：ADEKA ARGUS CHEMICAL CO., Ltd.

  公开号：EP0042622A1

  公开（公告）日：1981-12-30

  2,2,6,6-Tetramethyl-4-piperidyl spiro aliphatic ethers are provided, useful as stabilizers for organic polymeric materials and having the general formula: wherein: Y is X is selected from the group consisting of alkylene having from one to about eighteen carbon atoms; cycloalkylene having from three to about eight carbon atoms; arvlene having from about six to about eighteen carbon atoms; polyacyl wherein n1 is a number from 2 to 4; polycarbamoyl vherein n2 is a number from 2 to 4; and di- and trivalent oxyacid groups; R1 is selected from the group consisting of hydrogen, R2 is selected from the group consistinq of hvdroaen and R3 is selected from the group consisting of alkyl having from one to about eighteen carbon atoms; cycloalkyl having from three to about eight carbon atoms; aryl having from about six to about eighteen carbon atoms; and -X-O-R1; R4 is selected from the group consisting of hydrogen; aliphatic having from one to about eighteen carbon atoms; cycloaliphatic having from three to about eight carbon atoms; heterocyclic having from six to about eighteen carbon atoms; and aromatic having from six to about eighteen carbon atoms; R5 is selected from the group consisting of aliphatic having from one to about eighteen carbon atoms; cycloaliphatic having from three to about eight carbon atoms; heterocyclic having from six to about eighteen carbon atoms; and aromatic having from six to about eighteen carbon atoms; and monovalent oxyacid groups; R7 is selected from the group consisting of the residues of monohydric alcohols having from one to about eighteen carbon atoms and phenols having from six to about fifty carbon atoms; Rs is selected from the group consisting of and Rs is selected from the group consisting of aliphatic R5 and cycloaliphatic R5; and -CH2OR10; R10 is selected from the group consisting of hydrogen, R11 is selected from the group consisting of alkylene and oxyalkylene having from two to about ten carbon atoms and from zero to about five oxyether groups; cycloalkylene having from three to about eight carbon atoms; and arylene having from six to about fifty carbon atoms; and isocyanurate; R12 is the residue of mono-, di-, tri- or tetracarboxylic acid; R,3 is selected from the group consisting of hydrogen, R5, and -O-R5; m is a number from zero to 10; n is a number from zero to 4; p is zero or 1; q is a number from zero to 3; and r is zero or 1.

  本发明提供了 2,2,6,6-四甲基-4-哌啶基脂肪族螺醚，可用作有机聚合物材料的稳定剂，其通式为 其中Y 是 X 选自具有 1 至约 18 个碳原子的亚烷基；具有 3 至约 8 个碳原子的环烷基；具有约 6 至约 18 个碳原子的芳基；聚芳基 其中 n1 是 2 至 4 的数字；聚氨基甲酰基 其中 n2 的数值为 2 至 4； R1选自由氢组成的组、 R2 选自由氢和三价氧酸基团组成的组。 R3 选自由 1 至约 18 个碳原子的烷基、3 至约 8 个碳原子的环烷基、约 6 至约 18 个碳原子的芳基和-X-O-R1 所组成的组； R4 选自由氢、1 至 18 个碳原子的脂肪族、3 至 8 个碳原子的环脂族、6 至 18 个碳原子的杂环族和 6 至 18 个碳原子的芳香族组成的组； R5 选自由 1 至约 18 个碳原子的脂肪族、3 至约 8 个碳原子的环脂族、6 至约 18 个碳原子的杂环族和 6 至约 18 个碳原子的芳香族组成的组； 以及单价氧酸基团； R7 选自具有 1 至约 18 个碳原子的一元醇残基和具有 6 至约 50 个碳原子的苯酚残基组成的组； Rs 选自由下列物质组成的组 和 Rs 选自由脂肪族 R5 和环脂族 R5 组成的组；以及 -CH2OR10； R10 选自由氢组成的组、 R11 选自具有 2 至约 10 个碳原子和 0 至约 5 个氧醚基团的亚烷基和氧烷基、具有 3 至约 8 个碳原子的环烷基和具有 6 至约 50 个碳原子的芳基组成的组；以及异氰尿酸酯； R12 是一元、二元、三元或四元羧酸的残基； R,3选自由氢、R5和-O-R5组成的组； m 是零至 10 的数字； n 是零到 4 之间的数值 p 为零或 1 q 是零至 3 的数字；以及 r 为零或 1。
• Stabilisation of polymeric organic materials by using synergistic mixtures comprising sterically hindered cyclic amines and derivatives of 3-pyrazolidinone or 1,2,4-triazolidine-3,5-dione
  申请人：CIBA-GEIGY AG

  公开号：EP0517658A1

  公开（公告）日：1992-12-09

  The present invention relates to synergistic mixtures for stabilising polymeric organic materials against light, heat and oxidation; said synergistic mixtures contain sterically hindered cyclic amines and particular derivatives of 3-pyrazolidinone or 1,2,4-triazolidine-3,5-dione. In addition, the present invention relates to some new derivatives of 3-pyrazolidinone or 1,2,4-triazolidine-3,5-dione.

  本发明涉及用于稳定聚合有机材料，使其免受光、热和氧化影响的增效混合物；所述增效混合物包含立体受阻环胺和 3-吡唑烷酮或 1,2,4-三唑烷-3,5-二酮的特定衍生物。此外，本发明还涉及 3-吡唑烷酮或 1,2,4-三唑烷-3,5-二酮的一些新衍生物。