1-tetradecyloxy-2,5-dimethylbenzene | 1134643-02-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-tetradecyloxy-2,5-dimethylbenzene
• 英文别名: 1,4-dimethyl-2-tetradecoxybenzene
• CAS: 1134643-02-9
• 化学式: C₂₂H₃₈O
• 分子量: 318.543
• InChiKey: ATEZXQLBHYNRQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.3
• 重原子数：
  23
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-tetradecyloxy-2,5-dimethylbenzene 在 过氧化苯甲酰 N-溴代丁二酰亚胺(NBS) 作用下， 以 四氯化碳 为溶剂， 以23%的产率得到1-tetradecyloxy-2,5-bis(bromomethyl)benzene
  参考文献：
  名称：

  [EN] ANTIMICROBIAL AMPHIPHILES AND METHODS FOR THEIR USE
  [FR] AMPHIPHILES ANTIMICROBIENS ET PROCÉDÉS POUR LEUR UTILISATION

  摘要：

  公开号：

  WO2012054695A8
• 作为产物：
  描述：

  2,5-二甲基苯酚 、 溴代十四烷 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 48.0h， 以86%的产率得到1-tetradecyloxy-2,5-dimethylbenzene
  参考文献：
  名称：

  Bicephalic amphiphile architecture affects antibacterial activity

  摘要：

  A series of cationic amphiphiles, each with an aromatic core, was prepared and investigated for antimicrobial properties. The synthesized amphiphiles in this study are bicephalic (double-headed) in that they each possess two trimethylammonium head groups and a single linear alkoxy tail. Minimum inhibitory and minimum bactericidal concentrations of these amphiphiles were in the low micromolar range. Antimicrobial activities are highly sensitive to the chain length of the hydrophobic region, and modestly reliant on the relative positioning of the head groups on the aromatic core. These trends were more pronounced in time kill assays, wherein longer chain compounds required significantly shorter times to completely kill bacteria. Microscopy suggested that the mode of cell death was lysis. Strong inhibition was observed with both biscationic compounds and monocationic comparisons against Gram-positive bacteria: only biscationic amphiphiles maintained good activity versus the Gram-negative bacteria tested. These observations provide direction for future antimicrobial structural investigations. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.06.026

文献信息

• ANTIMICROBIAL AMPHIPHILES AND METHODS FOR THEIR USE
  申请人：Minbiole Kevin P.

  公开号：US20140148487A1

  公开（公告）日：2014-05-29

  The present invention is directed to compositions useful for antimicrobial applications. These compositions comprise amphiphilic compounds.

  本发明涉及用于抗微生物应用的组合物。这些组合物包括两性化合物。
• Antimicrobial amphiphiles and methods for their use
  申请人：Minbiole Kevin P.

  公开号：US08980925B2

  公开（公告）日：2015-03-17

  The present invention is directed to compositions useful for antimicrobial applications. These compositions comprise amphiphilic compounds.

  本发明涉及用于抗微生物应用的组合物。这些组合物包括两性化合物。
• [EN] ANTIMICROBIAL AMPHIPHILES AND METHODS FOR THEIR USE<br/>[FR] AMPHIPHILES ANTIMICROBIENS ET PROCÉDÉS POUR LEUR UTILISATION
  申请人：JAMES MADISON INNOVATIONS INC

  公开号：WO2012054695A8

  公开（公告）日：2012-05-31
• US7404632B2
  申请人：——

  公开号：US7404632B2

  公开（公告）日：2008-07-29
• US7438404B2
  申请人：——

  公开号：US7438404B2

  公开（公告）日：2008-10-21