1-(3-methylphenoxy)-2-(4-methylphenoxy)ethane | 98155-63-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-(3-methylphenoxy)-2-(4-methylphenoxy)ethane
• 英文别名: 1-methyl-3-[2-(4-methylphenoxy)ethoxy]benzene
• CAS: 98155-63-6
• 化学式: C₁₆H₁₈O₂
• 分子量: 242.318
• InChiKey: QNHVEQZNXFRLHS-UHFFFAOYSA-N

物化性质

• 沸点：
  380.5±30.0 °C(Predicted)
• 密度：
  1.049±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对甲酚 、 1-(2-溴乙氧基)-3-甲基苯 在 sodium hydroxide 作用下， 以 甲醇 、 二乙二醇二甲醚 、 水 为溶剂， 生成 1-(3-methylphenoxy)-2-(4-methylphenoxy)ethane
  参考文献：
  名称：

  1,2-BIS(3-METHYLPHENOXY)ETHANE COMPOSITION AND THERMAL RECORDING MEDIA MADE BY USING THE SAME

  摘要：

  公开号：

  EP1595714B1

文献信息

• 1,2-Bis(3-methylphenoxy)ethane composition and thermal recording media made by using the same
  申请人：Oda Shigeru

  公开号：US20070111887A1

  公开（公告）日：2007-05-17

  In a thermal recording medium including a basic chromogenic dye, a developer and a sensitizer, a composition for a thermal recording medium which composition contains 50 ppm to 5.0 mass % of 1-(3-methylphenoxy)-2-(4-methylphenoxy)ethane and/or 1,2-bis(4-methylphenoxy)ethane in 1,2-bis(3-methylphenoxy)ethane is used as said sensitizer, whereby the 1,2-bis(3-methylphenoxy)ethane compound is remarkably improved in milling property in the preparation of the above sensitizer, and a thermal recording medium is provided without impairing the colorability, etc., such as thermal colorability.

  在包括基本显色染料，显影剂和增感剂的热记录介质中，一种用于热记录介质的组合物，其中该组合物含有50 ppm至5.0质量％的1-（3-甲基苯氧基）-2-（4-甲基苯氧基）乙烷和/或1,2-双（4-甲基苯氧基）乙烷在1,2-双（3-甲基苯氧基）乙烷中用作所述增感剂，从而在制备上述增感剂时显着改善了1,2-双（3-甲基苯氧基）乙烷化合物的研磨性能，并提供了一种热记录介质，而不会损害颜色性等，例如热色性。
• 1,2-bis(3-methylphenoxy)ethane composition and thermal recording media made by using the same
  申请人：Sanko Co., Ltd

  公开号：US07566682B2

  公开（公告）日：2009-07-28

  In a thermal recording medium including a basic chromogenic dye, a developer and a sensitizer, a composition for a thermal recording medium which composition contains 50 ppm to 5.0 mass % of 1-(3-methylphenoxy)-2-(4-methylphenoxy)ethane and/or 1,2-bis(4-methylphenoxy)ethane in 1,2-bis(3-methylphenoxy)ethane is used as said sensitizer, whereby the 1,2-bis(3-methylphenoxy)ethane compound is remarkably improved in milling property in the preparation of the above sensitizer, and a thermal recording medium is provided without impairing the colorability, etc., such as thermal colorability.

  在包括基本色变染料、显影剂和增感剂的热记录介质中，一种用于热记录介质的组合物包含50 ppm至5.0质量％的1-(3-甲基苯氧基)-2-(4-甲基苯氧基)乙烷和/或1,2-双(4-甲基苯氧基)乙烷在1,2-双(3-甲基苯氧基)乙烷中用作所述增感剂，从而在上述增感剂的制备中显著改善了1,2-双(3-甲基苯氧基)乙烷化合物的磨研性能，并提供了一种热记录介质，不损害色彩性等性能，如热色变性能。
• Inhibitors of the Notch transcriptional activation complex and methods for use of the same
  申请人：UNIVERSITY OF MIAMI

  公开号：US10501413B2

  公开（公告）日：2019-12-10

  Disclosed herein are inhibitors of the Notch transcriptional activation complex, and methods for their use in treating or preventing diseases, such as cancer. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: Formula (I), wherein the substituents are as described.

  本文公开了 Notch 转录激活复合物的抑制剂，以及将其用于治疗或预防癌症等疾病的方法。本文所述的抑制剂可包括式（I）化合物及其药学上可接受的盐类：式 (I)，其中取代基如所述。
• EP1595714A4
  申请人：——

  公开号：EP1595714A4

  公开（公告）日：2006-05-31
• INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME
  申请人：SPYVEE Mark

  公开号：US20180086700A1

  公开（公告）日：2018-03-29

  Disclosed herein are inhibitors of the Notch transcriptional activation complex, and methods for their use in treating or preventing diseases, such as cancer. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: Formula (I), wherein the substituents are as described.