2-(8-bromooctyl)thiophene | 120756-37-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 2-(8-bromooctyl)thiophene
• 英文别名: 1-bromo-8-(thiophen-2-yl)octane
• CAS: 120756-37-8
• 化学式: C₁₂H₁₉BrS
• 分子量: 275.253
• InChiKey: GUESBRVAUQCPFJ-UHFFFAOYSA-N

物化性质

• 沸点：
  332.2±25.0 °C(Predicted)
• 密度：
  1.229±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(8-bromooctyl)thiophene 生成 10-thiophen-2-yl-decanoic acid
  参考文献：
  名称：

  Ring-closure reactions. 16. An improved procedure for the synthesis of (2,5)thiophenophan-1-ones and its application to a convenient preparation of dl-muscone

  摘要：

  DOI：

  10.1021/jo01298a029
• 作为产物：
  描述：

  噻吩 、 1,8-二溴辛烷 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 18.5h， 以35%的产率得到2-(8-bromooctyl)thiophene
  参考文献：
  名称：

  Bent-core mesogens with an aromatic unit at the terminal position

  摘要：

  具有萘中心单元和分子链末端位置芳香环的弯曲核液晶被合成，旨在增强纳米分离。

  DOI：

  10.1039/c6nj03908a

文献信息

• Anti-inflammatory furanones
  申请人：Allergan, Inc.

  公开号：US05134128A1

  公开（公告）日：1992-07-28

  New 5-hydroxy-2-furanone compounds having anti-inflammatory, immunosuppressive and anti-proliferative activity and are useful in treating psoriasis and modifying calcium homeostasis.

  新的具有抗炎、免疫抑制和抗增殖活性的5-羟基-2-呋喃酮化合物对治疗牛皮癣和调节钙稳态具有用处。
• Thiophene Based Europium β-Diketonate Complexes: Effect of the Ligand Structure on the Emission Quantum Yield
  作者：Christelle Freund、William Porzio、Umberto Giovanella、Francesco Vignali、Mariacecilia Pasini、Silvia Destri、Agnieszka Mech、Sebastiano Di Pietro、Lorenzo Di Bari、Placido Mineo

  DOI：10.1021/ic1021164

  日期：2011.6.20

  photophysical characterization, together with solid state and solution structure analysis, of a series of europium complexes based on β-diketonate ligands are reported. The Eu(III) complex emission, specifically its photoluminescence quantum yield (PL-QY), can be tuned by changing ligands which finely modifies the environment of the metal ion. Steady-state and time-resolved emission spectroscopy and

  报道了一系列基于β-二酮酸酯配体的of配合物的合成，分子和光物理表征，以及固态和溶液结构分析。Eu（III）配合物的发射，特别是其光致发光量子产率（PL-QY），可以通过改变配体来进行调节，这些配体可以精细地修饰金属离子的环境。报告了稳态和时间分辨发射光谱以及整体PL-QY测量，并且与某些选定化合物的晶体结构中观察到的几何特征有关。此外，基于与其他镧系元素的类似络合物的顺磁NMR被用于证明溶解后存在显着的结构重组，这证明了所观察到的固相和溶液态发射性质的差异。
• Singlet oxygen oxidation of substituted furans to 5-hydroxy-2(5H)-furanone
  作者：Gary C. M. Lee、Elizabeth T. Syage、Dale A. Harcourt、Judy M. Holmes、Michael E. Garst

  DOI：10.1021/jo00025a012

  日期：1991.12

  The conditions for the regiospecific singlet oxygen oxidation of various 2,4-disubstituted furans 9 to 4-substituted-2 (5H)-furanones 3 are developed. The presence of a C-2 substituent (e.g., trimethylsilyl, tert-butyldimethylsilyl, or tributylstannyl) in 9 is an absolute requirement for the formation of the 4-substituted-5-hydroxy-2(5H)-furanone regioisomer 3. When the C-2 substituent is triethylsilyl (TES) or TBDMS, however, apart from 3, the corresponding 5-trialkylsiloxy derivative 11 is also isolated in a significant amount. These silyl acetals are unexpectedly stable but can be hydrolyzed back to 3 on stirring with dilute acid. The formation of silyl acetals, to our knowledge, has never been reported in the singlet oxygen oxidation of (trialkylsilyl)furan. A plausible mechanism for their formation is proposed. The presence of a catalytic amount of water in the oxidation of 2-(trialkylsilyl)-4-substituted-furans not only eliminates the formation of the silyl acetals but also speeds up the rate of the oxidation process. Moreover, the oxidation can then be carried out at 0-degrees-C instead of at -78-degrees-C. Oxidation of 2-(1-hydroxyalkyl)-4-substituted-furans in the absence of a reducing agent gives little or no sign of 2,5-disubstituted-6-hydroxy-3(2H)-pyranone 23 but instead 26 selectively. Thus, the (1-hydroxy)alkyl group can be utilized as the trialkylsilyl or trialkylstannyl group in dictating the regioselectivity in the singlet oxygen oxidation of substituted furans.
• US5134128A
  申请人：——

  公开号：US5134128A

  公开（公告）日：1992-07-28
• US6166003A
  申请人：——

  公开号：US6166003A

  公开（公告）日：2000-12-26