(5-phenyl-1,3,4-oxadiazol-2-yl)acetonitrile | 7256-51-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (5-phenyl-1,3,4-oxadiazol-2-yl)acetonitrile
• 英文别名: 2-(5-phenyl-1,3,4-oxadiazol-2-yl)acetonitrile；2-(cyanomethyl)-5-phenyl-1,3,4-oxadiazole
• CAS: 7256-51-1
• 化学式: C₁₀H₇N₃O
• mdl: MFCD00232745
• 分子量: 185.185
• InChiKey: LKUIOYOICNVIDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  62.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (5-phenyl-1,3,4-oxadiazol-2-yl)acetonitrile 在 sodium azide 、 ammonium chloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以74%的产率得到5-(5-phenyl-1,3,4-oxadiazol-2-ylmethyl)tetrazole
  参考文献：
  名称：

  Polynuclear nonfused bis(1,3,4-oxadiazole)-containing systems

  摘要：

  Nonfused bis-1,3,4-oxadiazoles were synthesized by reaction of 5-substituted mono- and bis-tetrazoles with mono- and dicarboxylic acid chlorides. The results of kinetic studies showed that the transformation of tetrazoles into 1,3,4-oxadiazoles is accelerated by I to 2 orders of magnitude on addition of a catalytic amount of dimethylformamide, triethylamine, or pyridine.

  DOI：

  10.1134/s1070428006070219
• 作为产物：
  描述：

  cyanoacetobenzoylhydrazide 在 三氯氧磷 作用下， 反应 0.25h， 以70%的产率得到(5-phenyl-1,3,4-oxadiazol-2-yl)acetonitrile
  参考文献：
  名称：

  Recyclization of 2-imino-2h-1-benzopyrans under the influence of nucleophilic reagents. 1. New approach to the synthesis of 3-(1,3,4oxadi-, thiadi-, and triazolyl-2)coumarins

  摘要：

  DOI：

  10.1007/bf01165439

文献信息

• Synthesis of new 1,2,3-triazolo[1,5-a]quinazolinones
  作者：Nazariy T. Pokhodylo、Vasyl S. Matiychuk

  DOI：10.1002/jhet.321

  日期：——

  Synthesis of novel 3‐substituted‐1,2,3‐triazolo[1,5‐a]quinazolinones in high yields was performed via anionic hetero‐domino reaction of appropriate substituted 2‐azidobenzoates prepared from isatines and acetonitriles activated by 1,3‐thiazole, 1,3‐benzothiazole, 1,3,4‐oxadiazole, and 1,2,4‐oxadiazole rings. It was shown that acetonitriles exhibited high reactivity and were convenient methylenic compounds

  通过适当的取代的2-叠氮基苯甲酸酯的阴离子杂多米诺反应，合成高产率的新型3-取代的1,2,3,3-三唑并[1,5-a]喹唑啉酮，所述取代基由由1,3-活化的靛红和乙腈制备的2-叠氮基苯甲酸酯噻唑，1,3-苯并噻唑，1,3,4-恶二唑和1,2,4-恶二唑环。已表明乙腈显示出高反应性并且是用于此类反应的方便的亚甲基化合物，提供了快速的结构变化。J.杂环化​​学。（2010）。
• Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides
  申请人：——

  公开号：US20040063744A1

  公开（公告）日：2004-04-01

  This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with new piperidine 4-alkenyl derivatives that possess unique antiviral activity. More particularly, the present invention relates to compounds useful for the treatment of HIV and AIDS. The compounds of the invention for the general Formula I: 1 wherein: Z is 2 Q is selected from the group consisting of: 3 —W— is 4

  这项发明提供了具有药物和生物影响性能的化合物，它们的药物组合物和使用方法。具体而言，该发明涉及具有独特抗病毒活性的新哌啶4-烯基衍生物。更具体地说，本发明涉及用于治疗艾滋病毒和艾滋病的化合物。本发明的化合物为一般式I的化合物： 1 其中： Z是 2 Q是从以下组中选择的： 3 —W—是 4
• 3,5-Diaminopyrazoles and 1,3,4-Oxadiazoles From Cyanoacetothioimidates
  作者：Masataka Yokoyama、Kenzi Sato

  DOI：10.1055/s-1988-27719

  日期：——

  2-Substituted 3-amino-3-(methylthio)acrylonitriles cyanoketene S,N-acetals are synthesized by two convenient methods. The imino esters of their hydrochloride salts are found to be good starting materials for the synthesis of 4-substituted 3,5-diaminopyrazoles and 2,5-disubstituted 1,3,4-oxadiazoles.

  通过两种简便的方法合成了 2-取代的 3-氨基-3-(甲硫基)丙烯腈 S,N-乙缩醛。 发现其盐酸盐的亚氨基酯是合成 4-取代的 3,5-二氨基吡唑和 2,5-二取代的 1,3,4-恶二唑的良好起始材料。
• INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC 4-ALKENYL PIPERIDINE AMIDES
  申请人：Wang Tao

  公开号：US20080188481A1

  公开（公告）日：2008-08-07

  This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with new piperidine 4-alkenyl derivatives that possess unique antiviral activity. More particularly, the present invention relates to compounds useful for the treatment of HIV and AIDS. The compounds of the invention for the general Formula I: wherein: Z is Q is selected from the group consisting of: —W— is

  本发明提供了具有药物和生物影响性质的化合物，它们的制药组合物和使用方法。具体而言，本发明涉及具有独特的抗病毒活性的新的哌啶4-烯基衍生物。更具体地，本发明涉及用于治疗HIV和艾滋病的化合物。本发明的化合物一般公式为I：其中：Z是Q是从以下组中选择的：-W-是
• 4H,8H-Pyrano[2,3-f]chromene-4,8-diones as versatile precursors for the synthesis of 6-(1,2-oxazol-5-yl)-2H-chromene-2-ones
  作者：Oleg A. Lozinski、Tatyana V. Shokol、Vladimir P. Khilya

  DOI：10.1007/s00706-012-0844-z

  日期：2013.2

  An efficient and versatile synthesis of 3-azolyl-6-(1,2-oxazol-5-yl)-2H-chromene-2-ones using a Knoevenagel reaction and subsequent cleavage with hydroxylamine hydrochloride is described.