methoxyfumaric acid diethyl ester | 7071-60-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methoxyfumaric acid diethyl ester
• 英文别名: Methoxyfumarsaeure-diaethylester；Methoxyfumarsaeurediethylester；diethyl (Z)-2-methoxybut-2-enedioate
• CAS: 7071-60-5
• 化学式: C₉H₁₄O₅
• 分子量: 202.207
• InChiKey: ZANMURAVXCBFQH-SREVYHEPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methoxyfumaric acid diethyl ester 在 sodium hydroxide 作用下， 生成 2-methoxyfumaric acid
  参考文献：
  名称：

  Ralph et al., Journal of the Chemical Society, 1959, p. 1169,1178

  摘要：

  DOI：
• 作为产物：
  描述：

  重氮甲烷 、 草酰乙酸二乙酯 在 乙醚 作用下， 生成 methoxyfumaric acid diethyl ester
  参考文献：
  名称：

  Ralph et al., Journal of the Chemical Society, 1959, p. 1169,1178

  摘要：

  DOI：

文献信息

• Water – the best solvent for DMAP-mediated dual cyclization towards metal-free first synthesis of fully substituted phthalimides
  作者：Subhasis Samai、Debasish Ghosh、Uttam K. Das、Sanghamitra Atta、Saikat K. Manna、Dilip K. Maiti

  DOI：10.1039/c6gc00367b

  日期：——

  DMAP in water is exploited for a [2 + 2 + 2] and [3 + 2] cascade dual annulation for the first synthesis of fully-substituted phthalimides.

  在水中利用DMAP进行了[2 + 2 + 2]和[3 + 2]级联双环化反应，首次合成了全取代邻苯二甲酰亚胺。
• The effect of polar substituents on the conformation and stereochemistry of enolate radicals
  作者：B. Giese、W. Damm、F. Wetterich、H.-G. Zeitz、J. Rancourt、Y. Guindon

  DOI：10.1016/s0040-4039(00)73805-6

  日期：1993.9

  ESR measurements and AM1 calculations show that ester substituted radicals 2 and 6 prefer conformation A as a result of allylic strain effects. But dipolar repulsion between substituents X and CO2Et In 2 and 6 has a pronounced effect on the conformation and the stereoselectivity of radicals 2 and 6.

  ESR测量和AM1计算表明，由于烯丙基应变效应，酯取代的基团2和6更偏爱构象A。但是，取代基X和CO 2 Et In 2和6之间的偶极排斥力对自由基2和6的构象和立体选择性具有显着影响。
• COMPOSITION FOR REGULATING PLANT GROWTH, METHOD FOR TREATING PLANTS THEREWITH, AND ACTIVE INGREDIENT THEREOF
  申请人：Gorbunov, Sergei Valeryevich

  公开号：EP3473098A1

  公开（公告）日：2019-04-24

  A composition for regulating plant growth, the active ingredient of which is an ester of oxaloacetic acid or a salt thereof, or derivatives thereof, wherein the ester of oxaloacetic acid has the given formula, where R1 and R2 are independently selected from a series of C1-C18 alkyl groups, and wherein the content of the active ingredient corresponds to a concentration of from 10-11 M to 10-3 M. The active ingredients and compositions for regulating plant growth allow for treating plants in order to stimulate the growth thereof and achieve such advantages as increased yields, improved plant quality, improved nutrient absorption and enhanced stress resistance, while allowing such advantages to be achieved using a relatively small amount of an active ingredient(s) which is/are biodegradable and environmentally friendly.

  一种调节植物生长的组合物，其活性成分是草酰乙酸酯或其盐或其衍生物，其中草酰乙酸酯具有给定的式，其中 R1 和 R2 独立地选自一系列 C1-C18 烷基，活性成分的含量相当于 10-11 M 至 10-3 M 的浓度。调节植物生长的活性成分和组合物可以对植物进行处理，以刺激植物的生长，达到提高产量、改善植物质量、改善养分吸收和增强抗逆性等优点，同时只需使用相对少量的活性成分即可达到上述优点，而且活性成分可生物降解，对环境友好。
• [EN] SIRTUIN ACTIVATORS AND ACTIVATION ASSAYS<br/>[FR] ACTIVATEURS DE SIRTUINE ET DOSAGES D'ACTIVATION
  申请人：SIRTRIS PHARMACEUTICALS INC

  公开号：WO2011130595A2

  公开（公告）日：2011-10-20

  Provided are methods and compositions for detecting a compound that activates a sirtuin deacetylase activity on a fluorescent-free activation substrate in vitro. Further provided are sirtuin modulating compounds of the formulas (I) - (XXI), and related compounds (XXXI), (XXXII), (XXXIII), and (XXXIV), including the fluorescent free- substrate SIRT1 activator compounds of formulas (XL), (XI), (XII), and (XIII).
• Ralph et al., Journal of the Chemical Society, 1959, p. 1169,1178
  作者：Ralph et al.

  DOI：——

  日期：——