N-Cyclohexyl-2-(methylamino)-2-phenylethanamide | 18742-17-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Cyclohexyl-2-(methylamino)-2-phenylethanamide
• 英文别名: α-Methylamino-2-phenyl-N-cyclohexyl-acetamid；N-cyclohexyl-2-(methylamino)-2-phenylacetamide
• CAS: 18742-17-1
• 化学式: C₁₅H₂₂N₂O
• 分子量: 246.352
• InChiKey: HOODNKNHZTVUQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  环己胺 、 N-(Mesyloxy)-N-methylphenylacetanilide 以 二氯甲烷 为溶剂， 以72%的产率得到N-Cyclohexyl-2-(methylamino)-2-phenylethanamide
  参考文献：
  名称：

  Synthesis of .alpha.-azido and .alpha.-amino amides from N-[(methylsulfonyl)oxy]amides

  摘要：

  Effective new syntheses of 2-azido amides and 2-amino amides from N-(mesyloxy) amides 1 have been developed. 2-Azido amides are produced by treating 1 with sodium azide in the presence of 15-crown-5. 2-Amino amides result from the reaction of 1 with various amines. Regiochemical control in the preparation of 2-amino amides is possible by modulating the amine nucleophilicity by steric bulk.

  DOI：

  10.1021/jo00061a004

文献信息

• Acid-catalyzed reaction of isocyanide with a Schiff base. New and facile syntheses of imidazolidines
  作者：Takeo Saegusa、Naotake Takaishi、Iwao Tamura、Hiroyasu Fujii

  DOI：10.1021/jo01256a090

  日期：1969.4
• Synthesis of .alpha.-azido and .alpha.-amino amides from N-[(methylsulfonyl)oxy]amides
  作者：Robert V. Hoffman、Naresh K. Nayyar、Wenting Chen

  DOI：10.1021/jo00061a004

  日期：1993.4

  Effective new syntheses of 2-azido amides and 2-amino amides from N-(mesyloxy) amides 1 have been developed. 2-Azido amides are produced by treating 1 with sodium azide in the presence of 15-crown-5. 2-Amino amides result from the reaction of 1 with various amines. Regiochemical control in the preparation of 2-amino amides is possible by modulating the amine nucleophilicity by steric bulk.