N-(ethoxycarbonyl)methoxybenzylideneamine | 101934-61-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(ethoxycarbonyl)methoxybenzylideneamine
• 英文别名: N-(Methoxyphenylmethylen)carbamidsaeure-ethylester；N-ethoxycarbonyl-benzimidic acid methyl ester；N-Aethoxycarbonyl-benzimidsaeure-methylester；N-Carbaethoxy-benziminomethylaether；methyl (Z)-N-ethoxycarbonylbenzenecarboximidate
• CAS: 101934-61-6
• 化学式: C₁₁H₁₃NO₃
• 分子量: 207.229
• InChiKey: JEYFDHCGSVEVNR-BENRWUELSA-N

物化性质

• 沸点：
  82-85 °C(Press: 0.05 Torr)
• 密度：
  1.06±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.24
• 重原子数：
  15.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  47.89
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  N-(ethoxycarbonyl)methoxybenzylideneamine 在 盐酸 作用下， 生成 ethyl N-benzoylcarbamate
  参考文献：
  名称：

  Wheeler; Walden; Metcalf, American Chemical Journal, 1898, vol. 20, p. 73

  摘要：

  DOI：
• 作为产物：
  描述：

  S,S-diphenyl-N-(ethoxycarbonyl)sulfilimine 、 alkaline earth salt of/the/ methylsulfuric acid 在 氧气 作用下， 生成 N-(ethoxycarbonyl)methoxybenzylideneamine
  参考文献：
  名称：

  Reaction of chromium (Fischer) carbenes and sulfilimines

  摘要：

  The photochemical reactions of alkoxychromium (Fischer) carbenes and sulfilimines lead to imidates in fair to excellent yields. Aromatic, heteroaromatic, and alkylsulfilimines, the latter bearing functional groups such as cyano, sulfone, ether, ester, and dioxolane groups, gave the corresponding imidates in good to excellent yield. However, acyl- and sulfonyl-substituted sulfilimines did not react with chromium carbenes, except for sulfilimines bearing ethoxycarbonyl and phtalimidylamino groups. A variety of differently substituted chromium carbene complexes bearing alkyl, cycloalkyl, styryl, allyl, and alkynyl groups attached either at the carbene carbon or at the oxygen also gave imidates in good yields. For alpha,beta-unsaturated carbenes, the exclusive 1,2-addition of the sulfilimine nitrogen was observed at room temperature, in contrast to the behavior of other nitrogen nucleophiles which are reported to add in 1,4-fashion under these reaction conditions. In turn, optically active imidates of the type ArN=C(OR*)Me [R* = chiral substituent derived from (R)-(+)-1-phenyl-1-butanol, l-(-)-menthol, (1S)-endo-(-)-borneol, and (1R)-(-)-myrtenol] can be prepared efficiently by utilizing the corresponding chiral alkoxy group on the earbene moiety. The reactions above also occur in the dark but reaction times are considerably longer. N-Halosulfilimines reacted with alkoxychromium carbenes to yield N-acylsulfilimines instead of the expected N-haloimidates. Based upon a set of thermal and photochemical reactions between N-haloimidates and diphenyl sulfide in the absence of chromium complexes, the complex (CO)5CrNCMe is proposed to be responsible for this novel reaction of N-haloimidates and diphenyl sulfide.

  DOI：

  10.1021/jo00067a020

文献信息

• Allmann, Rudolf; Krestel, Magda; Kupfer, Rainer, Chemische Berichte, 1986, vol. 119, # 8, p. 2444 - 2457
  作者：Allmann, Rudolf、Krestel, Magda、Kupfer, Rainer、Wuerthwein, Ernst-Ulrich

  DOI：——

  日期：——
• MAXEY, CLAUDIA TATA;MCELWEE-WHITE, LISA, ORGANOMETALLICS, 10,(1991) N, C. 1913-1916
  作者：MAXEY, CLAUDIA TATA、MCELWEE-WHITE, LISA

  DOI：——

  日期：——
• EL, EFRIT, M. L.;HAJJEM, B.;BACCAR, B., J. SOC. CHIM. TUNIS, 1985, 2, N 2, 23-26
  作者：EL, EFRIT, M. L.、HAJJEM, B.、BACCAR, B.

  DOI：——

  日期：——
• ALLMANN R.; KRESTEL M.; KUPFER R.; WURTHWEIN E. -U., CHEM. BER., 119,(1986) N 8, 2444-2457
  作者：ALLMANN R.、 KRESTEL M.、 KUPFER R.、 WURTHWEIN E. -U.

  DOI：——

  日期：——
• Reaction of chromium (Fischer) carbenes and sulfilimines
  作者：Benito Alcaide、Luis Casarrubios、Gema Dominguez、Miguel A. Sierra

  DOI：10.1021/jo00067a020

  日期：1993.7

  The photochemical reactions of alkoxychromium (Fischer) carbenes and sulfilimines lead to imidates in fair to excellent yields. Aromatic, heteroaromatic, and alkylsulfilimines, the latter bearing functional groups such as cyano, sulfone, ether, ester, and dioxolane groups, gave the corresponding imidates in good to excellent yield. However, acyl- and sulfonyl-substituted sulfilimines did not react with chromium carbenes, except for sulfilimines bearing ethoxycarbonyl and phtalimidylamino groups. A variety of differently substituted chromium carbene complexes bearing alkyl, cycloalkyl, styryl, allyl, and alkynyl groups attached either at the carbene carbon or at the oxygen also gave imidates in good yields. For alpha,beta-unsaturated carbenes, the exclusive 1,2-addition of the sulfilimine nitrogen was observed at room temperature, in contrast to the behavior of other nitrogen nucleophiles which are reported to add in 1,4-fashion under these reaction conditions. In turn, optically active imidates of the type ArN=C(OR*)Me [R* = chiral substituent derived from (R)-(+)-1-phenyl-1-butanol, l-(-)-menthol, (1S)-endo-(-)-borneol, and (1R)-(-)-myrtenol] can be prepared efficiently by utilizing the corresponding chiral alkoxy group on the earbene moiety. The reactions above also occur in the dark but reaction times are considerably longer. N-Halosulfilimines reacted with alkoxychromium carbenes to yield N-acylsulfilimines instead of the expected N-haloimidates. Based upon a set of thermal and photochemical reactions between N-haloimidates and diphenyl sulfide in the absence of chromium complexes, the complex (CO)5CrNCMe is proposed to be responsible for this novel reaction of N-haloimidates and diphenyl sulfide.