1-benzyl-6-bromo-2-phenyl-1H-benzo[d]imidazole | 1609460-48-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-benzyl-6-bromo-2-phenyl-1H-benzo[d]imidazole
• 英文别名: 1-Benzyl-6-bromo-2-phenylbenzimidazole；1-benzyl-6-bromo-2-phenylbenzimidazole
• CAS: 1609460-48-1
• 化学式: C₂₀H₁₅BrN₂
• 分子量: 363.256
• InChiKey: VWCWAJMANZPRJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  n-苄基苯甲酰胺 在 氯化亚砜 、 碘苯二乙酸 、 三乙胺 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 9.17h， 生成 1-benzyl-6-bromo-2-phenyl-1H-benzo[d]imidazole
  参考文献：
  名称：

  Solvent/Oxidant-Switchable Synthesis of Multisubstituted Quinazolines and Benzimidazoles via Metal-Free Selective Oxidative Annulation of Arylamidines

  摘要：

  A fast and simple divergent synthesis of multisubstituted quinazolines and benzimidazoles was developed from readily available amidines, via iodine(III)-promoted oxidative C(sp(3))-C(sp(2)) and C(sp(2))-N bond formation in nonpolar and polar solvents, respectively. Further selective synthesis of quinazolines in polar solvent was realized by TEMPO-catalyzed sp(3)C-H/sp(2)C-H direct coupling of the amidine with K2S2O8 as the oxidant. No metal, base, or other additives were needed.

  DOI：

  10.1021/ol500864r

文献信息

• Electrochemical Synthesis of Benzo[<i>d</i>]imidazole via Intramolecular C(sp³)–H Amination
  作者：An Li、Caohui Li、Tao Yang、Zan Yang、Yu Liu、LiJun Li、KeWen Tang、Congshan Zhou

  DOI：10.1021/acs.joc.1c01842

  日期：2023.2.17

  An electrochemical dehydrogenative amination for the synthesis of benzimidazoles was developed. This electrosynthesis method could address the limitations of the C(sp3)–H intramolecular amination synthesis reaction and provide novel access to obtain 1,2-disubstituted benzimidazoles without transition metals and oxidants. Under undivided electrolytic conditions, various benzimidazole derivatives could

  开发了用于合成苯并咪唑的电化学脱氢胺化反应。这种电合成方法可以解决 C(sp3)-H 分子内胺化合成反应的局限性，并为在没有过渡金属和氧化剂的情况下获得 1,2-二取代苯并咪唑提供新途径。在未分割的电解条件下，可以合成各种苯并咪唑衍生物，表现出官能团耐受性。
• Design and Syntheses of Ruthenium ENE (E = S, Se) Pincer Complexes: A Versatile System for Catalytic and Biological Applications
  作者：Surabhi Bhatt、Neha Meena、Mukesh Kumar、Nattamai Bhuvanesh、Anil Kumar、Anuj K. Sharma、Hemant Joshi

  DOI：10.1002/asia.202200736

  日期：2022.11.2

  Two ruthenium ENE (E = S, Se) pincer complexes were designed and synthesized, and shown to constitute a versatile system for catalytic and biological applications.

  设计和合成了两种钌 ENE (E = S, Se) 钳形配合物，并证明它们构成了用于催化和生物应用的多功能系统。