2-乙酰氨基-3-(4-联苯)丙烯酸 | 599178-66-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-乙酰氨基-3-(4-联苯)丙烯酸
• 英文名称: (2E)-2-Acetamido-3-([1,1'-biphenyl]-4-yl)prop-2-enoic acid
• 英文别名: (E)-2-acetamido-3-(4-phenylphenyl)prop-2-enoic acid
• CAS: 599178-66-2
• 化学式: C₁₇H₁₅NO₃
• 分子量: 281.3
• InChiKey: QAIUEZSSLHVCGO-LFIBNONCSA-N

物化性质

• 沸点：
  554.8±50.0 °C(Predicted)
• 密度：
  1.228±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• PROCESS FOR MANUFACTURE OF N-ACYLBPHENYL ALANINE
  申请人：Zhejiang Jiuzhou Pharmaceutical Co., Ltd.

  公开号：EP2480523B1

  公开（公告）日：2017-03-01
• Process for Manufacture of N-acylbiphenyl alanine
  申请人：Zhu Guoliang

  公开号：US20130172572A1

  公开（公告）日：2013-07-04

  A novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors.
• Process for the Manufacture of N-acylbiphenyl alanine
  申请人：Zhu Guoliang

  公开号：US20140142320A1

  公开（公告）日：2014-05-22

  The invention relates to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors.
• PROCESS FOR THE MANUFACTURE OF N-ACYLBIPHENYL ALANINE
  申请人：Zhu Guoliang

  公开号：US20160115118A1

  公开（公告）日：2016-04-28

  The invention relates to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors.
• US9242927B2
  申请人：——

  公开号：US9242927B2

  公开（公告）日：2016-01-26