2-Methylbutyltosylat | 111803-43-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Methylbutyltosylat
• 英文别名: 1-(2-methylbutylsulfonyl)-4-methylbenzene；2-methyl-1-(p-toluenesulfonyl)butane；1-Methyl-4-(2-methylbutylsulfonyl)benzene
• CAS: 111803-43-1
• 化学式: C₁₂H₁₈O₂S
• 分子量: 226.34
• InChiKey: NLMYFVBQXWXVQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  S-(3,4-dihydroxyphenyl)-isothiourea 、 2-Methylbutyltosylat 生成 甲基-2-丁基巯基-4-邻苯二酚
  参考文献：
  名称：

  摘要：

  DOI：
• 作为产物：
  描述：

  Magnesium, chloro(2-methylbutyl)- 、 对甲苯磺酰氯 在 aluminum (III) chloride 、 吡啶 、 三苯基氧化膦 作用下， 以 二氯甲烷 为溶剂， 反应 92.0h， 以63%的产率得到2-Methylbutyltosylat
  参考文献：
  名称：

  Pyridine and triphenylphosphine oxide activation of sulfonyl chlorides in the syntheses of (E) alk-1-enyl sulfones

  摘要：

  This paper describes efficient and new approaches to (E) alk-1-enyl sulfones, starting from sulfonyl chloride/pyridine or sulfonyl chloride/triphenylphosphine complexes in the presence of (E) di-iso-butyl alk-1-enyl alanes.The use of CuCl in the presence of sulfonyl chloride/pyridine complexes or pyridine in the presence of sulfonyl chloride/triphenylphosphine complexes, respectively, results in a remarkable increase in the yields and conversions. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.09.056

文献信息

• Biphenyl-5-alkanoic acid derivatives and use thereof
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：US06376546B1

  公开（公告）日：2002-04-23

  Compounds represented by general formula I or salts thereof, wherein n is an integer of 2 or 3; R represents a straight-chain or branched saturated alkyl group having 4 or 4 carbon atoms, a cyclopentyl group, a cyclohexyl group or the like, Y represents a hydroxyl or amino group, A represents a hydrogen atom, a hydroxyl, methoxy, nitro group or the like, Q represents a hydrogen atom or a hydroxyl or methoxy group. They can be formulated to give pharmaceutical compositions that are effective as prophylactic or therapeutic agents for allergic diseases associated with IgE production inhibitors or IgE antibodies.

  由一般式I或其盐所代表的化合物，其中n是2或3的整数；R代表具有4个或4个碳原子的直链或支链饱和烷基基团，环戊基团，环己基团或类似物；Y代表羟基或氨基团；A代表氢原子，羟基，甲氧基，硝基团或类似物；Q代表氢原子或羟基或甲氧基团。它们可以配制成药物组合物，作为与IgE产生抑制剂或IgE抗体相关的过敏疾病的预防或治疗药剂。
• [EN] DEFORMYLASE INHIBITOR, PROCESS FOR PREPARING THE SAME, AND ANTIBACTERIAL COMPOSITION COMPRISING THE SAME<br/>[FR] INHIBITEUR DE DEFORMYLASE, PROCEDE D'ELABORATION, ET COMPOSITION ANTIBACTERIENNE RENFERMANT CET INHIBITEUR
  申请人：PROMEDITECH INC

  公开号：WO2004087643A1

  公开（公告）日：2004-10-14

  Provided are a novel compound useful for a deformylase inhibitor with excellent antibacterial activity or a pharmaceutically acceptable salt thereof, a process for preparing the same, and an antibacterial composition including the same as an active ingredient. The deformylase inhibitor effectively acts against a broad spectrum of bacteria, including bacteria with resistance to existing antibacterial agents.

  提供了一种新型化合物，用作脱甲酰酶抑制剂，具有出色的抗菌活性，或其药用盐，以及制备该化合物的方法，以及包含该化合物作为活性成分的抗菌组合物。脱甲酰酶抑制剂有效地对抗广谱细菌，包括对现有抗菌剂产生抗性的细菌。
• BIPHENYL-5-ALKANOIC ACID DERIVATIVES AND USE THEREOF
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP1024130A1

  公开（公告）日：2000-08-02

  Compounds represented by general formula (I) or salts thereof, wherein n is an integer of 2 or 3; R represents a straight-chain or branched saturated alkyl group having 4 or 5 carbon atoms, a cyclopentyl group, a cyclohexyl group or the like; Y represents a hydroxyl or amino group; A represents a hydrogen atom, a hydroxyl, methoxy, nitro group or the like; Q represents a hydrogen atom or a hydroxyl or methoxy group. They can be formulated to give pharmaceutical compositions that are effective as prophylactic or therapeutic agents for allergic diseases associated with IgE production inhibitors or IgE antibodies.

  由通式(I)代表的化合物或其盐类，其中n为2或3的整数；R代表具有4或5个碳原子的直链或支链饱和烷基、环戊基、环己基或类似基团；Y代表羟基或氨基；A代表氢原子、羟基、甲氧基、硝基或类似基团；Q代表氢原子或羟基或甲氧基。它们可以配制成药物组合物，作为预防或治疗与 IgE 生成抑制剂或 IgE 抗体相关的过敏性疾病的有效药物。
• ——
  作者：FOILET M.、 BONATO M.

  DOI：——

  日期：——
• NOVEL PHARMACEUTICAL COMPOSITIONS OF BENZENESULFONAMIDE DERIVATIVES FOR TREATMENT OF ADENOID CYSTIC CARCINOMA
  申请人：GONGWIN BIOPHARM HOLDINGS CO., LTD.

  公开号：US20170172951A1

  公开（公告）日：2017-06-22

  Provided is a method for treating adenoid cystic carcinoma by using a pharmaceutical composition including benzenesulfonamide derivatives and pharmaceutically acceptable carriers.