2-(diethylamino)ethyl-2,2-dicyclohexylpropanoate | 3579-28-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(diethylamino)ethyl-2,2-dicyclohexylpropanoate
• 英文别名: ZW62841；2,2-diphenyl-propionic acid-(3-diethylamino-propyl ester)；2,2-Diphenyl-propionsaeure-(3-diaethylamino-propylester)；3-(Diethylamino)propyl 2,2-diphenylpropanoate；3-(diethylamino)propyl 2,2-diphenylpropanoate
• CAS: 3579-28-0
• 化学式: C₂₂H₂₉NO₂
• 分子量: 339.478
• InChiKey: HLRFEMCLJCPZKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  25
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,2-二苯基丙酸 在 potassium carbonate 、 potassium hydrogencarbonate 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 13.0h， 生成 2-(diethylamino)ethyl-2,2-dicyclohexylpropanoate
  参考文献：
  名称：

  Synthesis of 2,2-Diphenylpropionate Derivatives and Their Effects on Larval Growth of the Silkworm

  摘要：

  合成了一系列具有氨基取代基的2,2-二苯基丙酸酯衍生物，并通过饮食施用法研究其对蚕（Bombyx mori）幼虫生长的影响。在测试的化合物中，3-(4-乙基哌嗪-1-基)丙基2,2-二苯基丙酸酯（3）显著延长了幼虫期。结构-活性关系研究表明，哌嗪环以及氮原子与酯基之间的键长对于这一活性非常重要。与对照组相比，化合物3的处理使血淋巴中ecdysteroid浓度的增加延迟了3天，这与蜕皮的延迟相关联。

  DOI：

  10.1271/bbb.64.610

文献信息

• Therapeutic compositions for diabetic symmetrical polyneuropathy
  申请人：Fernyhough Paul

  公开号：US10307428B2

  公开（公告）日：2019-06-04

  Compositions for therapy of a diabetic symmetrical polyneuropathy a subject in need thereof, the compositions comprising: an effective amount of a muscarinic acetylcholine receptor antagonist exemplified by pirenzepine, telenzepine, atropine, or derivatives thereof or salts thereof or analogs thereof or derivatives thereof, and a pharmacologically acceptable carrier. The composition may be injectable or alternatively, may be applied topically or alternatively, may be delivered orally. A suitable topical composition may comprise a lotion, a cream, a gel, or a viscous fluid. The muscarinic acetylcholine receptor antagonist may be a muscarinic acetylcholine receptor antagonist salt or a muscarinic acetylcholine receptor antagonist derivative or a muscarinic acetylcholine receptor antagonist analog.

  用于治疗糖尿病对称性多发性神经病变的组合物，该组合物包括：有效量的毒蕈碱乙酰胆碱受体拮抗剂，例如哌仑西平、替氮平、阿托品或其衍生物或其盐或其类似物或其衍生物，以及药理学上可接受的载体。该组合物可以注射，也可以局部使用，还可以口服。合适的局部组合物可包括乳液、膏霜、凝胶或粘稠液体。毒蕈碱乙酰胆碱受体拮抗剂可以是毒蕈碱乙酰胆碱受体拮抗剂盐或毒蕈碱乙酰胆碱受体拮抗剂衍生物或毒蕈碱乙酰胆碱受体拮抗剂类似物。
• THERAPEUTIC COMPOSITIONS FOR DIABETIC SYMMETRICAL POLYNEUROPATHY
  申请人：Fernyhough Paul

  公开号：US20130267506A1

  公开（公告）日：2013-10-10

  Compositions for therapy of a diabetic symmetrical polyneuropathy a subject in need thereof, the compositions comprising: an effective amount of a muscarinic acetylcholine receptor antagonist exemplified by pirenzepine, telenzepine, atropine, or derivatives thereof or salts thereof or analogs thereof or derivatives thereof, and a pharmacologically acceptable carrier. The composition may be injectable or alternatively, may be applied topically or alternatively, may be delivered orally. A suitable topical composition may comprise a lotion, a cream, a gel, or a viscous fluid. The muscarinic acetylcholine receptor antagonist may be a muscarinic acetylcholine receptor antagonist salt or a muscarinic acetylcholine receptor antagonist derivative or a muscarinic acetylcholine receptor antagonist analog.
• TREATMENTS FOR DIABETIC SYMMETRICAL POLYNEUROPATHY
  申请人：University of Manitoba

  公开号：US20190046540A1

  公开（公告）日：2019-02-14

  Treatments for therapy of a diabetic symmetrical polyneuropathy a subject in need thereof. The treatments includes administration of compositions comprising: an effective amount of a muscarinic acetylcholine receptor antagonist exemplified by pirenzepine, telenzepine, atropine, or derivatives thereof or salts thereof or analogs thereof or derivatives thereof, and a pharmacologically acceptable carrier. The composition may be injectable or alternatively, may be applied topically or alternatively, may be delivered orally. A suitable topical composition may comprise a lotion, a cream, a gel, or a viscous fluid. The muscarinic acetylcholine receptor antagonist may be a muscarinic acetylcholine receptor antagonist salt or a muscarinic acetylcholine receptor antagonist derivative or a muscarinic acetylcholine receptor antagonist analog.
• Synthesis of 2,2-Diphenylpropionate Derivatives and Their Effects on Larval Growth of the Silkworm
  作者：Nozomu TOYOMURA、In-Hae KIM、Tetsuya YOSHIDA、Takahiro SHIOTSUKI、Eiichi KUWANO

  DOI：10.1271/bbb.64.610

  日期：2000.1

  A variety of 2,2-diphenylpropionate derivatives with an amino substituent were synthesized and their effects on larval growth of the silkworm, Bombyx mori, were examined by dietary administration. Of the compounds tested, 3-(4-ethylpiperazin-1-yl)propyl 2,2-diphenylpropionate (3) caused significant prolongation of the larval period. Studies on the structure-activity relationship indicate that a piperazine ring and the bond distances between the nitrogen atom and the ester group were important for this activity. Treatment of compound 3 delayed the increase of ecdysteroid titers in the hemolymph by 3 days compared with that of the control, which correlates with the delay in molting.

  合成了一系列具有氨基取代基的2,2-二苯基丙酸酯衍生物，并通过饮食施用法研究其对蚕（Bombyx mori）幼虫生长的影响。在测试的化合物中，3-(4-乙基哌嗪-1-基)丙基2,2-二苯基丙酸酯（3）显著延长了幼虫期。结构-活性关系研究表明，哌嗪环以及氮原子与酯基之间的键长对于这一活性非常重要。与对照组相比，化合物3的处理使血淋巴中ecdysteroid浓度的增加延迟了3天，这与蜕皮的延迟相关联。