methyl 4-[[2-[(4-chlorophenyl)sulfonylamino]indan-5-yl]acetylamino]-n-butyrate | 123653-63-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 4-[[2-[(4-chlorophenyl)sulfonylamino]indan-5-yl]acetylamino]-n-butyrate
• 英文别名: methyl 4-[[2-[2-[(4-chlorophenyl)sulfonylamino]-2,3-dihydro-1H-inden-5-yl]acetyl]amino]butanoate
• CAS: 123653-63-4；123654-07-9；123654-08-0
• 化学式: C₂₂H₂₅ClN₂O₅S
• 分子量: 464.97
• InChiKey: FVMGEDMQPDXFDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  methyl 4-[[2-[2-[(4-chlorophenyl)sulfonylamino]-2,3-dihydro-1H-inden-5-yl]-2-hydroxyacetyl]amino]butanoate 以74%的产率得到
  参考文献：
  名称：

  IVAKUMA, TAKEHO;YAMASITA, TOEXARU;KONO, TOYUKI

  摘要：

  DOI：

文献信息

• Indan derivatives used for treating thromboses or asthma
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：US05190975A1

  公开（公告）日：1993-03-02

  Method for the treatment or prophylaxis of thromboses or asthma in warm-blooded animal which comprises administering an effective amount of a compound having the formula: ##STR1## wherein R.sup.1 is phenyl group or phenyl group substituted by a member selected from the group consisting of C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy, halogen atom, trifluoromethyl, and nitro, or naphthyl group, and R.sup.2 is hydroxymethyl or a group of the formula: ##STR2## wherein R.sup.3 is hydrogen atom or C.sub.1 -C.sub.5 alkyl and R.sup.4 is C.sub.3 -C.sub.6 cycloalkyl, C.sub.2 -C.sub.6 alkoxycarbonyl-phenyl, carboxy-phenyl, C.sub.1 -C.sub.5 alkyl, or C.sub.1 -C.sub.5 alkyl having a substituent selected from C.sub.1 -C.sub.5 alkoxycarbonyl, carboxy, C.sub.2 -C.sub.6 alkoxycarbonyl-phenyl, carboxy-phenyl, C.sub.2 -C.sub.6 alkoxycarbonyl-(C.sub.3 -C.sub.6) cycloalkyl and carboxy-(C.sub.3 -C.sub.6) cycloalkyl, or a pharmaceutically acceptable salt thereof to said warm blooded animal.

  治疗或预防温血动物的血栓或哮喘的方法，包括向温血动物投予具有以下结构式的化合物的有效量：其中R^1为苯基或苯基取代物，所述取代物选自C_1-C_5烷基、C_1-C_5烷氧基、卤原子、三氟甲基和硝基，或萘基；R^2为羟甲基或以下结构式的基团：其中R^3为氢原子或C_1-C_5烷基，R^4为C_3-C_6环烷基、C_2-C_6烷氧羰基苯基、羧基苯基、C_1-C_5烷基，或C_1-C_5烷基，其具有以下取代基之一：C_1-C_5烷氧羰基、羧基、C_2-C_6烷氧羰基苯基、羧基苯基、C_2-C_6烷氧羰基-(C_3-C_6)环烷基和羧基-(C_3-C_6)环烷基，或其在温血动物中的药用盐。
• Indan derivatives and pharmaceutical preparation thereof
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：US05030652A1

  公开（公告）日：1991-07-09

  Indan derivatives of the formula: ##STR1## wherein R.sup.1 is substituted or unsubstituted phenyl, naphthyl or sulfur-containing heterocyclic group, and R.sup.2 is hydroxy-methyl or a group of the formula: ##STR2## wherein R.sup.3 is hydrogen atom or lower alkyl and R.sup.4 is cycloalkyl, lower alkoxycarbonyl-phenyl, carboxy-phenyl, nitrogen-containing heterocyclic group, lower alkyl, or lower alkyl having a substituent selected from lower alkoxycarbonyl, carboxy, lower alkoxycarbonyl-phenyl, carboxy-phenyl, lower alkoxycarbonyl-cycloalkyl and carboxy-cycloalkyl, or a pharmaceutically acceptable salt thereof, which are useful as a platelet aggregation-inhibiting agent and as an agent for the treatment, amelioration and/or prophylaxis of a variety of thrombosis or embolism, coronary and cerebral vascular smooth muscle vellication, asthma, and the like, processes for the preparation thereof, and pharmaceutical composition containing said compound as an active ingredient.

  印度衍生物的公式：##STR1##其中R.sup.1是取代或未取代的苯基，萘基或含硫杂环基团，R.sup.2是羟甲基或公式的基团：##STR2##其中R.sup.3是氢原子或较低的烷基，R.sup.4是环状烷基，较低的烷氧羰基苯基，羧基苯基，含氮杂环基团，较低的烷基，或较低的烷基，其具有从较低的烷氧羰基，羧基，较低的烷氧羰基苯基，羧基苯基，较低的烷氧羰基环状烷基和羧基环状烷基中选择的取代基，或其药学上可接受的盐，它们有用作血小板聚集抑制剂和用于治疗、改善和/或预防各种血栓或栓塞，冠状和脑血管平滑肌痉挛，哮喘等的剂，其制备过程和含有该化合物作为活性成分的制药组合物。
• Indan derivatives and process for preparation thereof
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP0317321A2

  公开（公告）日：1989-05-24

  tndan derivatives of the formula: wherein R1 is substituted or unsubstituted phenyl, naphthyl or sulfur-containing heterocyclic group, and R2 is hydroxymethyl or a group of the formula: wherein R3 is hydrogen atom or lower alkyl and R4 is cycloalkyl, lower alkoxycarbonyl-phenyl, carboxy-phenyl, nitrogen-containing heterocyclic group, lower alkyl, or lower alkyl having a substituent selected from lower alkoxycarbonyl, carboxy, lower alkoxycarbonyl-phenyl, carboxy-phenyl, lower alkoxycarbonyl-cycloalkyl and carboxy-cycloalkyl, or a pharmaceutically acceptable salt thereof, which are useful as a platelet aggregation-inhibiting agent and as an agent for the treatment, amelioration and/or prophylaxis of a variety of thrombosis or embolism, coronary and cerebral vascular smooth muscle vellication, asthma, and the like, processes for the preparation thereof, and pharmaceutical composition containing said compound as an active ingredient.

  式中 R1 为取代或未取代的苯基、萘基或含硫杂环基团，R2 为羟甲基或式中 其中 R1 是取代或未取代的苯基、萘基或含硫杂环基团，R2 是羟甲基或式中的一个基团： 其中 R3 是氢原子或低级烷基，R4 是环烷基、低级烷氧基羰基苯基、羧基苯基、含氮杂环基团、低级烷基或具有选自低级烷氧基羰基、羧基、低级烷氧基羰基苯基、羧基苯基、低级烷氧基羰基环烷基和羧基环烷基的取代基的低级烷基，或其药学上可接受的盐、可用作血小板聚集抑制剂和治疗、改善和/或预防各种血栓形成或栓塞、冠状动脉和脑血管平滑肌肿胀、哮喘等的药物、其制备工艺以及含有上述化合物作为活性成分的药物组合物。
• IVAKUMA, TAKEHO;YAMASITA, TOEXARU;KONO, TOYUKI
  作者：IVAKUMA, TAKEHO、YAMASITA, TOEXARU、KONO, TOYUKI

  DOI：——

  日期：——
• US5030652A
  申请人：——

  公开号：US5030652A

  公开（公告）日：1991-07-09