((2S,4S)-4-azidopyrrolidin-2-yl)diphenylmethanol | 1041199-42-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ((2S,4S)-4-azidopyrrolidin-2-yl)diphenylmethanol
• 英文别名: [(2S,4S)-4-azidopyrrolidin-2-yl]-diphenylmethanol
• CAS: 1041199-42-1
• 化学式: C₁₇H₁₈N₄O
• 分子量: 294.356
• InChiKey: WYMKHBYKWSXDJD-HOTGVXAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  46.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ((2S,4S)-4-azidopyrrolidin-2-yl)diphenylmethanol 、 1-庚炔 在 溴化三(三苯基磷)铜 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 以92%的产率得到((2S,4S)-4-(4-pentyl-1H-1,2,3-triazol-1-yl)pyrrolidin-2-yl)diphenylmethanol
  参考文献：
  名称：

  1,2,3-Triazole-linked dendrimers as a support for functionalized and recoverable catalysts for asymmetric borane reduction of prochiral ketones

  摘要：

  A series of new, functionalized, and chiral catalysts have been synthesized based on 1,2,3-triazole-linked dendrimers. It has been found that dendrimer 7f is an efficient catalyst for the enantio selective borane reduction of both electron-deficient and electron-rich ketones, and high enantioselectivities were obtained (up to 96%). The catalyst can be recovered and reused four times without a significant loss of catalytic activity. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.03.019
• 作为产物：
  描述：

  ethyl (2S,4S)-4-azido-2-(hydroxy(diphenyl)methyl)pyrrolidine-1-carboxylate 在 氢氧化钾 作用下， 以 甲醇 为溶剂， 反应 8.0h， 以86%的产率得到((2S,4S)-4-azidopyrrolidin-2-yl)diphenylmethanol
  参考文献：
  名称：

  1,2,3-Triazole-linked dendrimers as a support for functionalized and recoverable catalysts for asymmetric borane reduction of prochiral ketones

  摘要：

  A series of new, functionalized, and chiral catalysts have been synthesized based on 1,2,3-triazole-linked dendrimers. It has been found that dendrimer 7f is an efficient catalyst for the enantio selective borane reduction of both electron-deficient and electron-rich ketones, and high enantioselectivities were obtained (up to 96%). The catalyst can be recovered and reused four times without a significant loss of catalytic activity. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.03.019

文献信息

• 1,2,3-Triazole-linked dendrimers as a support for functionalized and recoverable catalysts for asymmetric borane reduction of prochiral ketones
  作者：Yan-Ning Niu、Ze-Yi Yan、Gao-Qiang Li、Hai-Long Wei、Guo-Lin Gao、Lu-Yong Wu、Yong-Min Liang

  DOI：10.1016/j.tetasy.2008.03.019

  日期：2008.5

  A series of new, functionalized, and chiral catalysts have been synthesized based on 1,2,3-triazole-linked dendrimers. It has been found that dendrimer 7f is an efficient catalyst for the enantio selective borane reduction of both electron-deficient and electron-rich ketones, and high enantioselectivities were obtained (up to 96%). The catalyst can be recovered and reused four times without a significant loss of catalytic activity. (C) 2008 Elsevier Ltd. All rights reserved.