2-十一烷基十三烷酸 | 103212-65-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2-十一烷基十三烷酸
• 英文名称: 2-undecyltridecanoic acid
• 英文别名: 2-Undecyl-tridecansaeure
• CAS: 103212-65-3
• 化学式: C₂₄H₄₈O₂
• 分子量: 368.644
• InChiKey: IJFOZNKRFQDSCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.8
• 重原子数：
  26
• 可旋转键数：
  21
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-十一烷基十三烷酸 在 lithium aluminium tetrahydride 、 乙醚 作用下， 生成 2-undecyltridecan-1-ol
  参考文献：
  名称：

  Ulusoy, Istanbul Universitesi Fen Fakultesi Mecmuasi, Seri C: [Astronomi-Fizik-Kimya], 1954, vol. 19, p. 169

  摘要：

  DOI：
• 作为产物：
  描述：

  diethyl 2,2-diundecylmalonate 在 氢氧化钾 作用下， 生成 2-十一烷基十三烷酸
  参考文献：
  名称：

  Ulusoy, Istanbul Universitesi Fen Fakultesi Mecmuasi, Seri C: [Astronomi-Fizik-Kimya], 1954, vol. 19, p. 46

  摘要：

  DOI：

文献信息

• TREHALOSE COMPOUND, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL PRODUCT CONTAINING THE COMPOUND
  申请人：Nishizawa Mugio

  公开号：US20110218171A1

  公开（公告）日：2011-09-08

  A trehalose compound having high immunopotentiating activity and low toxicity is represented by formula (1). (In the formula, X and X′ each represents a phenyl, a naphthyl, R 1 —CHR 1 — (wherein R 1 and R 2 each represents a C 7 -C 21 alkyl group or the like) or the like; and n and n′ each independently represents an integer of 0-3). The compound exhibits a high activating effect on macrophages and neutrophils.

  具有高免疫增强活性和低毒性的海藻糖化合物由公式（1）表示。（在公式中，X和X'分别表示苯基，萘基，R1-CHR1-（其中R1和R2各代表C7-C21烷基或类似物），n和n'各自独立地表示0-3的整数）。该化合物对巨噬细胞和中性粒细胞具有高激活作用。
• Ugi Reaction Mediated Detergent Assembly for Membrane Protein Studies
  作者：Meifang Yang、Weiling Luo、Wei Zhang、Huixia Wang、Dongxiang Xue、Yiran Wu、Suwen Zhao、Fei Zhao、Xing Zheng、Houchao Tao

  DOI：10.1002/asia.202200372

  日期：2022.8

  Ugi reaction mediated modular assembly strategy allows convenient diversification of detergents. New detergents were evaluated over a broad spectra of membrane proteins. Optimum detergent M-23-M was further illustrated its application in the NMR study of a G protein-coupled receptor.

  Ugi 反应介导的模块化组装策略允许洗涤剂的方便多样化。在广泛的膜蛋白范围内评估了新的去污剂。最佳去污剂 M-23-M 进一步说明了其在 G 蛋白偶联受体核磁共振研究中的应用。
• FUCOSE DERIVATIVES, DRUGS CONTAINING THE SAME AS ACTIVE INGREDIENT, AND INTERMEDIATES FOR PRODUCING THE SAME
  申请人：KANEBO, LTD.

  公开号：EP0859005A1

  公开（公告）日：1998-08-19

  A compound of the formula (I): wherein X1 is a group of one of the following formulae (1), (2) and (3): R1 is a branched long chain alkyl group, R2 is ―CONHR3, a carboxyl group or a hydrogen atom, n is an integer of 0, 1 or 2, and R3 is a lower alkyl group or a phenyl group, or a pharmaceutically acceptable salt thereof, which is useful as a selectin inhibitor, and can be used in the prophylaxis or treatment of various inflammatory diseases such as inflammatory dermatitis (e.g., atopic dermatitis, contact hypersensitivity, photodermatosis, etc.), autoimmune chronic diseases (e.g. rheumatoid arthritis, chronic thyroiditis, etc.), and ischemia-reperfusion injury.

  式 (I) 的化合物： 其中 X1 是下式（1）、（2）和（3）之一的基团： R1是支链长链烷基，R2是-CONHR3、羧基或氢原子，n是0、1或2的整数，R3是低级烷基或苯基，或其药学上可接受的盐，可作为选择素抑制剂，用于预防或治疗各种炎症性疾病，如炎症性皮炎（如、特应性皮炎、接触性过敏、光敏性皮肤病等）、自身免疫性慢性疾病（如类风湿性关节炎、慢性甲状腺炎等）以及缺血再灌注损伤。
• Trehalose compound, method for producing same, and pharmaceutical product containing the compound
  申请人：Otsuka Chemical Co., Ltd.

  公开号：EP2567963A1

  公开（公告）日：2013-03-13

  It is an object of the present invention to provide a trehalose compound having high immunopotentiating activity and low toxicity. The compound exhibits a high activating effect on macrophages and neutrophils. The trehalose compound is represented by formula (1), wherein X represents R1-CHR2-, and X' represents R1'-CHR2'-, wherein R1, R1', R2 and R2' independently represent a C1-C21 alkyl group or a hydrogen atom, and wherein n and n' independently represent an integer of 0 to 3.

  本发明的目的是提供一种具有高免疫增强活性和低毒性的三卤糖化合物。该化合物对巨噬细胞和中性粒细胞具有很高的激活作用。 该曲卤糖化合物由式（1）表示，其中 X 代表 R1-CHR2-，X'代表 R1'-CHR2'-，其中 R1、R1'、R2 和 R2'独立地代表 C1-C21 烷基或氢原子，n 和 n'独立地代表 0 至 3 的整数。
• Development of Vizantin, a Safe Immunostimulant, Based on the Structure–Activity Relationship of Trehalose-6,6′-dicorynomycolate
  作者：Hirofumi Yamamoto、Masataka Oda、Mayo Nakano、Naoyuki Watanabe、Kenta Yabiku、Masahiro Shibutani、Masahisa Inoue、Hiroshi Imagawa、Masahiro Nagahama、Seiichiro Himeno、Kojun Setsu、Jun Sakurai、Mugio Nishizawa

  DOI：10.1021/jm3016443

  日期：2013.1.10

  Vizantin, 6,6'-bis-O-(3-nonyldodecanoy1)-alpha,alpha'-trehalose, was developed as a safe immunostimulator on the basis of a structure-activity relationship (SAR) study with trehalose 6,6'-dicorynomycolate (TDCM). It was possible to synthesize vizantin on a large scale more easily than in the case of TDCM, and the compound exhibited more potent prophylactic effect on experimental lung metastasis of B16-F0 melanoma cells. Because vizantin stimulated human macrophages, it is a promising candidate for clinical application.