17β-hydroxy-17α-ethyl-5α-androstan-3-one | 20112-30-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 17β-hydroxy-17α-ethyl-5α-androstan-3-one
• 英文别名: 17β-hydroxy-5α,17α-pregnan-3-one；17β-Hydroxy-3-oxo-17α-aethyl-5α-androstan；17beta-Hydroxy-17alpha-ethyl-5alpha-androstan-3-one；17-hydroxy-5α,17βH-pregnan-3-one；17β-hydroxy-17α-methyl-methyl-5α-androstane-3-one；17-Hydroxy-5α.17βH-pregnanon-(3)；17-Hydroxy-5α,17βH-pregnan-3-on；Pregnan-3-one, 17-hydroxy-, (5alpha,17alpha)-；(5S,8R,9S,10S,13S,14S,17S)-17-ethyl-17-hydroxy-10,13-dimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-one
• CAS: 20112-30-5
• 化学式: C₂₁H₃₄O₂
• 分子量: 318.5
• InChiKey: GPUVTXKHQDYRQO-JJFNZWTKSA-N

物化性质

• 熔点：
  126-127 °C
• 沸点：
  429.7±45.0 °C(Predicted)
• 密度：
  1.048±0.06 g/cm3(Predicted)
• 溶解度：
  溶于二氯甲烷、甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  17β-hydroxy-17α-ethyl-5α-androstan-3-one 在 copper(II) sulfate 、 溶剂黄146 、 铂 作用下， 140.0 ℃ 、1.33 Pa 条件下， 生成 5α-pregnan-3β-ol
  参考文献：
  名称：

  Facilitating Children's Understanding of Misinterpretation: Explanatory Efforts and Improvements in Perspective Taking

  摘要：

  The authors investigated children's understanding of how mistaken beliefs can arise through misinterpretation of ambiguous information. Children (N = 91), aged 4 to 5 years, were given pre- and posttests on their ability to infer a puppet's interpretation of a restricted-view drawing after the puppet had been led to an erroneous expectation about the drawing's identity. Before the posttest, the children received either self-explanation training or other-explanation training in which they explained the source of their own or a puppet's misinterpretations of drawings; a control group received no training. The children who received training improved from pre- to posttest, and those who had practiced explaining misinterpretations by referring to previously viewed pictures or to features of a target picture showed the greatest improvement. These results indicate that learning to explain misinterpretations can help children recognize situations in which misinterpretations are likely to occur.

  DOI：

  10.1080/00221320209598673
• 作为产物：
  描述：

  17α-ethynyldihydrotestosterone 在 palladium on activated charcoal 氢气 、 碳酸氢钠 作用下， 以 various solvents 为溶剂， 反应 16.0h， 以65%的产率得到17β-hydroxy-17α-ethyl-5α-androstan-3-one
  参考文献：
  名称：

  用硼酸酯选择性处理甾体羟基：有效利用抗原C-3连接的甾体-蛋白质结合物和甾体硫酸盐标准物进行药物检测。

  摘要：

  作为硼酸酯的17alpha-烷基-5alpha-androstane-3beta，16beta，17beta三醇的临时保护是对其区域选择性功能化的有效方法。这已被应用于蛋白质-类固醇结合物7-10的合成，该蛋白-类固醇结合物的开发适用于针对澳大利亚赛马和其他体育比赛中禁止的类固醇的免疫测定。还报道了用作参考标准的类固醇硫酸盐缀合物42和44的合成。

  DOI：

  10.1039/b610499a

文献信息

• Synthesis and substance P receptor binding activity of androstano[3,2-b]pyrimido[1,2-a]benzimidazoles
  作者：Bhaskar R. Venepalli、Lisa D. Aimone、Kenneth C. Appell、Malcolm R. Bell、John A. Dority、Ramanuj Goswami、Patricia L. Hall、Virendra Kumar、Kristine B. Lawrence

  DOI：10.1021/jm00080a025

  日期：1992.1

  Several heterosteroids containing a dihydroethisterone skeleton were prepared and shown to displace substance P in a receptor binding assay. Further biochemical (kinetic and Scatchard analyses) and pharmacological evaluation (substance P-induced plasma extravasation and salivation in the rat) of a representative example in this series (5a) established that these compounds are competitive antagonists

  制备了几种含有二氢乙二酮骨架的杂类固醇，并在受体结合试验中显示出可取代物质P的性质。该系列（5a）中代表性实例的进一步生化（动力学和Scatchard分析）和药理评估（大鼠中P诱导的血浆渗出和唾液分泌）确定了这些化合物是P物质受体的竞争性拮抗剂。
• Sexualhormone X. Herstellung des 17-Methyl-testosterons und anderer Androsten- und Androstanderivate. Zusammenhänge zwischen chemischer Konstitution und männlicher Hormonwirkung
  作者：L. Ruzicka、M. W. Goldberg、H. R. Rosenberg

  DOI：10.1002/hlca.193501801203

  日期：——
• Steroids. CV.¹ 2-Methyl and 2-Hydroxymethylene-androstane Derivatives
  作者：H. J. Ringold、E. Batres、O. Halpern、E. Necoechea

  DOI：10.1021/ja01511a040

  日期：1959.1
• Polynuclear cyclic oxyketones and derivatives thereof and process of making same
  申请人：SOC OF CHEMICAL IND

  公开号：US02143453A1

  公开（公告）日：1939-01-10
• DE758807
  申请人：——

  公开号：——

  公开（公告）日：——