trimethyl[2,2,2-trifluoro-1-(2-pyridyl)-1-(trifluoromethyl)ethoxy]silane | 848347-45-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: trimethyl[2,2,2-trifluoro-1-(2-pyridyl)-1-(trifluoromethyl)ethoxy]silane
• 英文别名: 2-[2,2,2-Trifluoro-1-(trifluoromethyl)-1-[(trimethylsilyl)oxy]ethyl]pyridine；(1,1,1,3,3,3-hexafluoro-2-pyridin-2-ylpropan-2-yl)oxy-trimethylsilane
• CAS: 848347-45-5
• 化学式: C₁₁H₁₃F₆NOSi
• 分子量: 317.306
• InChiKey: NTPQVEYFKUIQAF-UHFFFAOYSA-N

物化性质

• 沸点：
  34 °C(Press: 0.07 Torr)
• 密度：
  1.233±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.25
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2-吡啶甲酸 在 四甲基氟化铵 、 N,N'-二环己基碳二亚胺 作用下， 以 1,4-二氧六环 、 乙二醇二甲醚 为溶剂， 反应 1.0h， 生成 trimethyl[2,2,2-trifluoro-1-(2-pyridyl)-1-(trifluoromethyl)ethoxy]silane
  参考文献：
  名称：

  Convenient syntheses of 1,1,1,3,3,3-hexafluoro-2-organyl-propan-2-ols and the corresponding trimethylsilyl ethers

  摘要：

  A new convenient synthetic procedure to obtain various 1, 1, 1,3,3,3-hexafluoro-2-organyl-propan-2-ols and the corresponding trimethylsilyl ethers has been worked out starting from anhydrides or activated esters of carboxylic acids and trimethyl(trifluoromethyl)silane in the presence of tetramethylammonium fluoride. Conditions for the selective formation of 1, 1, 1,3,3,3-hexafluoro-2-organyl-propan-2-ols as well as the trimethylsilyl derivatives have been found. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.12.023

文献信息

• Convenient syntheses of 1,1,1,3,3,3-hexafluoro-2-organyl-propan-2-ols and the corresponding trimethylsilyl ethers
  作者：L.A. Babadzhanova、N.V. Kirij、Yu.L. Yagupolskii、W. Tyrra、D. Naumann

  DOI：10.1016/j.tet.2004.12.023

  日期：2005.2

  A new convenient synthetic procedure to obtain various 1, 1, 1,3,3,3-hexafluoro-2-organyl-propan-2-ols and the corresponding trimethylsilyl ethers has been worked out starting from anhydrides or activated esters of carboxylic acids and trimethyl(trifluoromethyl)silane in the presence of tetramethylammonium fluoride. Conditions for the selective formation of 1, 1, 1,3,3,3-hexafluoro-2-organyl-propan-2-ols as well as the trimethylsilyl derivatives have been found. (C) 2004 Elsevier Ltd. All rights reserved.