Ethyl-1-benzyl-1,6-dihydro-6-oxopyridin-3-carboxylat | 24903-84-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Ethyl-1-benzyl-1,6-dihydro-6-oxopyridin-3-carboxylat
• 英文别名: 1-Benzyl-5-carbethoxy-2-pyridon；1-benzyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester；1-Benzyl-6-oxo-1,6-dihydro-pyridin-3-carbonsaeure-aethylester；ethyl 1-benzyl-6-keto-1,6-dihydronicotinate；Ethyl 1-benzyl-6-oxopyridine-3-carboxylate
• CAS: 24903-84-2
• 化学式: C₁₅H₁₅NO₃
• 分子量: 257.289
• InChiKey: PRNQFKSOSWOSJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Ethyl-1-benzyl-1,6-dihydro-6-oxopyridin-3-carboxylat 在 一水合肼 作用下， 生成 1-benzyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid hydrazide
  参考文献：
  名称：

  Sugasawa et al., Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1952, vol. 72, p. 192

  摘要：

  DOI：
• 作为产物：
  描述：

  氯化苄 在 硫酸 作用下， 生成 Ethyl-1-benzyl-1,6-dihydro-6-oxopyridin-3-carboxylat
  参考文献：
  名称：

  Sugasawa et al., Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1952, vol. 72, p. 192

  摘要：

  DOI：

文献信息

• Five‐Membered Nitrogen Heterocycles Synthesis through 1,3‐Dipolar Cycloaddition of Non‐Stabilized Azomethine Ylides with 2‐Pyridone Heteroaromatic Systems as Dipolarophiles
  作者：Sami Ben Salah、Morgane Sanselme、Yves Champavier、Mohamed Othman、Adam Daïch、Isabelle Chataigner、Ata Martin Lawson

  DOI：10.1002/ejoc.202001404

  日期：2021.1.8

  3‐dipolar cycloadditions of non‐stabilized azomethine ylides with diversely substituted 2‐pyridone systems, bearing two potential C=C dipolarophilic sites was reported. The TFA‐catalyzed cycloadditions involving the in situ prepared electron‐rich 1,3‐dipole are studied according to the nature of pyridone substituents. These reactions occur in mild conditions, good yields, and show a full control of the

  据报道，一系列带有两个潜在的C = C双亲性位点的，不稳定的偶氮甲亚胺的高效1,3-偶极环加成反应，带有不同取代的2-吡啶酮体系。根据吡啶酮取代基的性质，研究了TFA催化的环加成反应，该反应涉及就地制备的富电子的1,3-偶极子。这些反应在温和的条件下发生，具有良好的收率，并显示出对区域选择性的完全控制。
• Über die Reaktion einiger 2<i>H</i>-Pyran-2-on-Derivate mit primären Aminen
  作者：Vratislav Kvita、Hanspeter Sauter、Grety Rihs

  DOI：10.1002/hlca.19910740218

  日期：1991.3.13

  On the Reaction of Some 2H-Pyran-2-one Derivatives with Primary Amines

  关于一些2 H -Pyran-2-one衍生物与伯胺的反应
• Method for generating mature β-like cells
  申请人：The University of Western Australia

  公开号：US10568913B2

  公开（公告）日：2020-02-25

  The present invention relates to methods for generating mature insulin-producing β-like cells comprising the steps: (a) isolating, purifying and/or enriching β-cell progenitor cells from a population of cells; (b) differentiation of the β-cell progenitor cells into immature insulin-producing β-like cells; and (c) maturation of the immature insulin-producing β-like cells into mature insulin-producing β-like cells, comprising exposing the immature insulin-producing β-like cells to calcitriol or an analogue thereof. More particularly, the present invention relates to methods for generating mature insulin-producing β-like cells for use in treating diabetes.

  本发明涉及产生成熟的胰岛素分泌β样细胞的方法，包括以下步骤： (a)从细胞群中分离、纯化和/或富集β细胞祖细胞；(b)将β细胞祖细胞分化为未成熟的胰岛素分泌β样细胞；(c)将未成熟的胰岛素分泌β样细胞成熟为成熟的胰岛素分泌β样细胞，包括将未成熟的胰岛素分泌β样细胞暴露于钙三醇或其类似物。 更具体地说，本发明涉及产生用于治疗糖尿病的成熟胰岛素分泌β样细胞的方法。
• KVITA, VRATISLAV;SAUTER, HANSPETER;RIHS, GRETY, HELV. CHIM. ACTA, 74,(1991) N, C. 407-416
  作者：KVITA, VRATISLAV、SAUTER, HANSPETER、RIHS, GRETY

  DOI：——

  日期：——
• METHOD FOR GENERATING MATURE BETA-LIKE CELLS
  申请人：THE UNIVERSITY OF WESTERN AUSTRALIA

  公开号：US20160045554A1

  公开（公告）日：2016-02-18

  The present invention relates to methods for generating mature insulin-producing β-like cells comprising the steps: (a) isolating, purifying and/or enriching β-cell progenitor cells from a population of cells; (b) differentiation of the β-cell progenitor cells into immature insulin-producing β-like cells; and (c) maturation of the immature insulin-producing β-like cells into mature insulin-producing β-like cells, comprising exposing the immature insulin-producing β-like cells to calcitriol or an analogue thereof. More particularly, the present invention relates to methods for generating mature insulin-producing β-like cells for use in treating diabetes.