2-吡啶-3-基-3-(2-吡啶-3-基吡啶-4-基)吡啶 | 59697-14-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-吡啶-3-基-3-(2-吡啶-3-基吡啶-4-基)吡啶
• 英文名称: nemertelline
• 英文别名: 2-pyridin-3-yl-3-(2-pyridin-3-ylpyridin-4-yl)pyridine
• CAS: 59697-14-2
• 化学式: C₂₀H₁₄N₄
• 分子量: 310.358
• InChiKey: SWWRILUGNLIYGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,4-二氯吡啶 在 四(三苯基膦)钯 potassium carbonate 作用下， 反应 99.33h， 生成 2-吡啶-3-基-3-(2-吡啶-3-基吡啶-4-基)吡啶
  参考文献：
  名称：

  Revised Structure and Convergent Synthesis of Nemertelline, the Neurotoxic Quaterpyridine Isolated from the Hoplonemertine Sea Worm

  摘要：

  The correct structure of the quaterpyridine nemertelline first isolated from hoplonemertine sea worms has been identified as 2 (3,2':3',4 '':2 '',3triple prime-quaterpyridine). The natural product was synthesized using palladium(0)-catalyzed cross-coupling of 3-(tributylstannyl)-2,3'-bipyridine (3) and 4-chloro-2,3'-bipyridine (4). The bipyridines were prepared in the presence of the Pd catalyst by cross-coupling 2-bromo-3-(tributylstannyl)pyridine (5) and 2,4-dichloropyridine with 3-diethyl(pyridyl)borane, respectively. X-ray analysis confirmed the structure of 2 and provided its conformation in the solid state. The proton NMR spectrum of 2 identifies it as the natural product first reported in 1976.

  DOI：

  10.1021/jo00128a021

文献信息

• Materials and methods for inhibiting fouling of surfaces exposed to aquatic environments
  申请人：——

  公开号：US20040235901A1

  公开（公告）日：2004-11-25

  The subject invention provides materials and methods for inhibiting the biofouling of surfaces exposed to aquatic environments. In one embodiment, the subject invention provides additives for marine paints and surface treatments. The subject invention further provides repellants and selective inhibitors for aquatic and/or terrestrial crustacean pests.

  本主题发明提供了用于抑制暴露在水生环境中的表面生物污垢的材料和方法。在一个实施例中，本主题发明提供了用于海洋涂料和表面处理的添加剂。本主题发明还提供了用于水生和/或陆生甲壳动物害虫的驱避剂和选择性抑制剂。
• An Efficient Two-Step Total Synthesis of the Quaterpyridine Nemertelline
  作者：Alexandre Bouillon、Anne Sophie Voisin、Audrey Robic、Jean-Charles Lancelot、Valérie Collot、Sylvain Rault

  DOI：10.1021/jo034805b

  日期：2003.12.1

  Regioselective and univocal Suzuki cross-coupling reactions performed on halopyridinyl boronic acids provide a flexible and versatile route to a multigram scale synthesis of 2,2'-dichloro-3,4'-bipyridine 14, which allows couplings with excess pyridin-3-yl boronic acid to give a new and efficient two-step rapid synthesis of nemertelline, the quaterpyridine neurotoxin isolated from a Hoplonemertine sea worm

  在卤代吡啶基硼酸上进行的区域选择性和明确的Suzuki交叉偶联反应为2,2'-dichloro-3,4'-联吡啶14的克级合成提供了灵活而灵活的途径，该方法可与过量的吡啶-3-基偶联硼酸可提供一种新的高效的两步快速合成奈美特林的方法，奈美特林是一种从霍普莫美汀海蠕虫中分离出来的季吡啶神经毒素。
• Methods and compositions for treating cancer using P2RX2 inhibitors
  申请人：Flagship Pioneering Innovations V, Inc.

  公开号：US10457740B1

  公开（公告）日：2019-10-29

  The present invention provides methods for treating cancer using P2RX2 inhibitors, such as P2RX2 inhibitory antibodies, among others. The invention also features compositions containing P2RX2 inhibitors, methods of diagnosing patients with P2RX2-associated cancer, and methods of predicting the response of cancer in a subject to treatment with P2RX2 inhibitors.

  本发明提供了使用 P2RX2 抑制剂（如 P2RX2 抑制抗体等）治疗癌症的方法。本发明还包括含有 P2RX2 抑制剂的组合物、诊断 P2RX2 相关癌症患者的方法以及预测癌症对 P2RX2 抑制剂治疗的反应的方法。
• Methods for treating cancer using GRM8 inhibitors
  申请人：Flagship Pioneering Innovations V, Inc.

  公开号：US10683352B1

  公开（公告）日：2020-06-16

  The present invention provides methods for treating cancer using mGluR8 inhibitors, such as mGluR8 inhibitory antibodies and small molecules. The invention also features compositions containing mGluR8 inhibitors, methods of diagnosing patients with mGluR8-associated cancer, and methods of predicting the response of cancer in a subject to treatment with mGluR8 inhibitors.

  本发明提供了使用mGluR8抑制剂（如mGluR8抑制抗体和小分子）治疗癌症的方法。本发明还包括含有 mGluR8 抑制剂的组合物、诊断 mGluR8 相关癌症患者的方法以及预测癌症对 mGluR8 抑制剂治疗的反应的方法。
• Methods and compositions for treating cancer using SERCA pump inhibitors
  申请人：Flagship Pioneering Innovations V, Inc.

  公开号：US11013717B1

  公开（公告）日：2021-05-25

  The present invention provides methods for treating cancer using sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) pump inhibitors, such as SERCA pump inhibitory antibodies, among others. The invention also features compositions containing SERCA pump inhibitors, methods of diagnosing patients with SERCA pump-associated cancer, and methods of predicting the response of cancer in a subject to treatment with SERCA pump inhibitors.

  本发明提供了使用肌浆/内质网Ca2+-ATP酶（SERCA）泵抑制剂（如SERCA泵抑制抗体等）治疗癌症的方法。本发明还包括含有 SERCA 泵抑制剂的组合物、诊断 SERCA 泵相关癌症患者的方法以及预测癌症对 SERCA 泵抑制剂治疗的反应的方法。