Phosphonic acid, (2-oxo-3-phenoxybutyl)-, dimethyl ester | 40665-72-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: Phosphonic acid, (2-oxo-3-phenoxybutyl)-, dimethyl ester
• 英文别名: 1-dimethoxyphosphoryl-3-phenoxybutan-2-one
• CAS: 40665-72-3
• 化学式: C₁₂H₁₇O₅P
• 分子量: 272.23
• InChiKey: COFLVLMANLHHLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• 2,5,6,7-TETRANOR-4,8-INTER-m-PHENYLENE PGI 2 DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND USE THEREOF
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP0365678A1

  公开（公告）日：1990-05-02

  2,5,6,7-Tetranor-4,8-inter-m-phenylene PGl2 derivatives such as 16-methyl-2,5,6,-tetranor-4,8-!nter-m-phenylene PGl2 and its methyl ester, 17-methyl-2,5,6,7-tetranor-4,8-inter-m-phenylene PGl2 and its methyl ester, 15-phenyl-2,5,6,7,16,17,18,19,20-nonanor-4,8-inter-m-phenylene PGI2, 16-methyl-17-phenyl-2,5,6,7,18,19,20-heptanor-4,8-l-nter-m- phenylene PGl2, 16,16-dimethyl-17-phenyl-2,5,6,7,18,19,20-heptanor--4,8-inter-m-phenylene PG12, 16-methyl-16-phenoxy-2.5,6,7,17,18,19,20-octanor-4, 8- ,inter-m-phenylene PGI2, 16-methyl-16-phenoxy-2,5,6,7,18,19,20-heptanor-4,8--inter-m- phenylene PGl2 and its methyl ester and 3-decarboxy-3-hydroxymethyl-16-methyl-16-phenoxy-2,5.6.7,18,19,20-heptanor- 4,8-inter-m-phenylene PG12, useful as medicines, are disclosed. These derivatives are useful as, for example, antiulceric agents, hypotensives, and antithrombotic agents.

  nter-m-phenylene PGl2 及其甲酯、17-甲基-2,5,6,7-tetranor-4,8-inter-m-phenylene PGl2 及其甲酯、15-苯基-2,5,6,7,16,17,18,19,20-nonanor-4,8-inter-m-phenylene PGI2、16-methyl-17-phenyl-2,5,6,7,18,19,20-heptanor-4,8-l-nter-m- phenylene PGl2, 16,16-dimethyl-17-phenyl-2,5,6,7,18,19,20-heptanor--4,8-inter-m-phenylene PG12, 16-methyl-16-phenoxy-2.5,6,7,17,18,19,20-辛硼烷-4,8-间亚苯基 PGI2、16-甲基-16-苯氧基-2,5,6,7,18,19,20-庚硼烷-4,8-间亚苯基 PGl2 及其甲酯和 3-癸羧基-3-羟甲基-16-甲基-16-苯氧基-2,5,6,7,18,19,20-庚硼烷-4,8-间亚苯基 PGl2 及其甲酯。6.7,18,19,20-heptanor- 4,8-inter-m-phenylene PG12，可用作药物。这些衍生物可用作抗溃疡剂、降血压剂和抗血栓剂等。
• Prostaglandin derivatives, their preparation and their therapeutic use
  申请人：Sankyo Company Limited

  公开号：EP0276124B1

  公开（公告）日：1992-05-20
• US3931279A
  申请人：——

  公开号：US3931279A

  公开（公告）日：1976-01-06
• US4087616A
  申请人：——

  公开号：US4087616A

  公开（公告）日：1978-05-02
• US4116988A
  申请人：——

  公开号：US4116988A

  公开（公告）日：1978-09-26