N-methyl-N-vinyl-2-methylpropanamide | 13044-12-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-methyl-N-vinyl-2-methylpropanamide
• 英文别名: N-ethenyl-N,2-dimethylpropanamide
• CAS: 13044-12-7
• 化学式: C₇H₁₃NO
• 分子量: 127.186
• InChiKey: MWAITTXTRUIKOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-methyl-N-vinylpropanamide 、 碘甲烷 在 lithium diisopropyl amide 作用下， 生成 N-methyl-N-vinyl-2-methylpropanamide
  参考文献：
  名称：

  Chockalingam, Kannappan; Harirchian, Bijan; Bauld, Nathan L., Synthetic Communications, 1990, vol. 20, # 2, p. 189 - 202

  摘要：

  DOI：

文献信息

• [EN] MULTIFOCAL CONTACT LENS DISPLAYING IMPROVED VISION ATTRIBUTES<br/>[FR] LENTILLE DE CONTACT MULTIFOCALE PRÉSENTANT DES ATTRIBUTS DE VISION AMÉLIORÉS
  申请人：JOHNSON & JOHNSON VISION CARE

  公开号：WO2021038369A1

  公开（公告）日：2021-03-04

  Described are multifocal contact lenses that contain high energy visible (HEV) light absorbing compounds and their use for improving one or more vision attributes.

  描述了含有吸收高能可见光（HEV）的化合物的多焦点隐形眼镜，以及它们用于改善一个或多个视力属性的用途。
• [EN] CONTACT LENS DISPLAYING IMPROVED VISION ATTRIBUTES<br/>[FR] LENTILLES DE CONTACT PRÉSENTANT DES ATTRIBUTS DE VISION AMÉLIORÉS
  申请人：JOHNSON & JOHNSON VISION CARE

  公开号：WO2021038368A1

  公开（公告）日：2021-03-04

  Described are contact lenses that contain high energy visible (HEV) light absorbing compounds and their use for improving one or more vision attributes.

  描述了含有吸收高能可见光（HEV）的化合物的隐形眼镜，以及它们用于改善一个或多个视觉属性的用途。
• [EN] POLYMERIZABLE FUSED TRICYCLIC COMPOUNDS AS ABSORBERS OF UV AND VISIBLE LIGHT<br/>[FR] COMPOSÉS TRICYCLIQUES FUSIONNÉS POLYMÉRISABLES EN TANT QU'ABSORBEURS DE LUMIÈRE UV ET VISIBLE
  申请人：JOHNSON & JOHNSON VISION CARE

  公开号：WO2020261021A1

  公开（公告）日：2020-12-30

  Described are polymerizable fused tricyclic compounds of formula I: wherein R1, R2, R3, m, n, t, and rings B, C, and D are as defined herein. The compounds absorb various wavelengths of ultraviolet and/or visible light (such as high energy visible light) and are suitable for incorporation in a variety of products, such as biomedical devices and ophthalmic devices.

  描述了公式I的可聚合的融合三环化合物，其中R1、R2、R3、m、n、t和环B、C和D的定义如本文所述。这些化合物吸收各种紫外线和/或可见光波长（如高能可见光），适用于各种产品中，如生物医学器械和眼科器械。
• POLYMER COMPOSITIONS CONTAINING GRAFTED POLYMERIC NETWORKS AND PROCESSES FOR THEIR PREPARATION AND USE
  申请人：Johnson & Johnson Vision Care, Inc.

  公开号：US20180037690A1

  公开（公告）日：2018-02-08

  Provided are polymer compositions made by a process comprising: (a) providing a first reactive composition containing: (i) a polymerization initiator that is capable, upon a first activation, of forming two or more free radical groups, at least one of which is further activatable by subsequent activation; (ii) one or more ethylenically unsaturated compounds; and (iii) a crosslinker; (b) subjecting the first reactive composition to a first activation step such that the first reactive composition polymerizes therein to form a crosslinked substrate network containing a covalently bound activatable free radical initiator, (c) combining the crosslinked substrate network with a second reactive composition containing one or more ethylenically unsaturated compounds; and (d) activating the covalently bound activatable free radical initiator of the crosslinked substrate network such that the second reactive composition polymerizes therein with the crosslinked substrate network to form a grafted polymeric network and a byproduct polymer. Also provided are precursors to the polymer compositions, processes for preparation of the polymer compositions, and methods of using the polymer compositions, for instance in medical devices.

  提供的是由包括以下步骤的过程制备的聚合物组合物：(a)提供含有：(i)能够在第一激活时形成两个或更多自由基团的聚合引发剂，其中至少一个可以通过后续激活进一步激活；(ii)一个或多个乙烯基不饱和化合物；和(iii)交联剂的第一反应组合物；(b)将第一反应组合物暴露于第一激活步骤，使第一反应组合物在其中聚合形成含有共价结合的可激活自由基引发剂的交联基底网络；(c)将交联基底网络与含有一个或多个乙烯基不饱和化合物的第二反应组合物结合；和(d)激活交联基底网络的共价结合的可激活自由基引发剂，使第二反应组合物在其中与交联基底网络聚合形成嵌接聚合物网络和副产物聚合物。还提供了聚合物组合物的前体、制备聚合物组合物的过程以及使用聚合物组合物的方法，例如在医疗器械中的应用。
• HYDROXYPHENYL PHENANTHROLINES AS POLYMERIZABLE BLOCKERS OF HIGH ENERGY LIGHT
  申请人：Johnson & Johnson Vision Care, Inc.

  公开号：US20190002459A1

  公开（公告）日：2019-01-03

  Described are high energy light blocking compounds and ophthalmic devices containing the compounds. In particular, described are hydroxyphenyl phenanthroline structures with polymerizable functionality that block high energy light and are visibly transparent. The hydroxyphenyl phenanthroline structures can be incorporated into ophthalmic devices, such as hydrogel contact lenses, to protect eyes from high energy light radiation.

  描述了高能量光阻挡化合物和含有这些化合物的眼科器械。具体来说，描述了含有可聚合功能的羟基苯基菲啰啉结构，这些结构可以阻挡高能量光并且具有可见透明性。这些羟基苯基菲啰啉结构可以被应用到眼科器械中，比如水凝胶隐形眼镜，以保护眼睛免受高能量光辐射的伤害。