4-Hydroxy-2-methylpentansaeure | 41654-03-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-Hydroxy-2-methylpentansaeure
• 英文别名: 4-Hydroxy-3-methylpentansaeure；4-hydroxy-3-methyl-valeric acid；3-Methyl-pentanol-(4)-saeure-(1)；4-Hydroxy-3-methyl-valeriansaeure；γ-Oxy-β-methyl-butan-α-carbonsaeure；γ-Oxy-β-methyl-n-valeriansaeure；4-Hydroxy-3-methylpentanoic acid
• CAS: 41654-03-9
• 化学式: C₆H₁₂O₃
• 分子量: 132.159
• InChiKey: BNTHHYUWQILHSA-UHFFFAOYSA-N

物化性质

• 沸点：
  270.8±23.0 °C(Predicted)
• 密度：
  1.097±0.06 g/cm3(Predicted)
• 保留指数：
  2642

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-甲基-4-氧代戊酸 在 sodium tetrahydroborate 作用下， 生成 4-Hydroxy-2-methylpentansaeure
  参考文献：
  名称：

  鉴定双胞胎兄弟姐妹尿中的5-羟基己酸与二羧酸尿症和低血糖症相关，且与牙买加呕吐病相似，且具有类似雷耶氏综合征。

  摘要：

  在英国哈罗出现的双胞胎男婴同胞，患有雷耶氏综合征，伴有严重的低血糖，呕吐，腹泻，昏迷和一个孩子的死亡，伴有二羧酸尿症，与贾马斯式呕吐病（低血糖素毒性）相似排泄大量以前未记录的尿有机酸。使用合成的标准物通过气相色谱质谱法已将其鉴定为5-羟基己酸。两名患者中观察到的浓度分别为340和330 mg g-1肌酐。尿酸的代谢前体被认为是六-4-烯酸，这是一种可能的化学毒素，与次糖的活性有机酸代谢产物密切相关。

  DOI：

  10.1002/bms.1200061008

文献信息

• Compounds and compositions for use in the prevention and treatment of obesity and related syndromes
  申请人：Chapal Nicolas

  公开号：US20060223884A1

  公开（公告）日：2006-10-05

  The invention relates to 4-hydroxyisoleucine, isomers, analogs, lactones, salts, and prodrugs thereof, to processes for their preparation, and to pharmaceutical compositions comprising the same. More particularly, the invention relates to the use of those compounds in the prevention and treatment of obesity and related syndromes.

  本发明涉及4-羟基异亮氨酸、其同分异构体、类似物、内酯、盐和前药，以及它们的制备过程，以及包含它们的药物组合物。更具体地说，本发明涉及这些化合物在预防和治疗肥胖及相关综合症中的用途。
• Analogs of 4-hydroxyisoleucine and uses thereof
  申请人：Mioskowski Charles

  公开号：US20060199853A1

  公开（公告）日：2006-09-07

  The invention relates to analogs of 4-hydroxyisoleucine, and to lactones, pharmaceutically acceptable salts, and prodrugs thereof, to processes for their preparation, and to pharmaceutical compositions comprising the same. The analogs of the invention stimulate both glucose uptake and insulin secretion, and may thus be useful for the prevention and treatment of disorders of carbohydrate or lipid metabolism, including diabetes mellitus (type 1 and type 2 diabetes), pre-diabetes, and Metabolic Syndrome.

  本发明涉及4-羟基异亮氨酸的类似物，以及它们的内酯、药物可接受的盐和前药，其制备过程，以及包含它们的药物组合物。发明的这些类似物能够刺激葡萄糖摄取和胰岛素分泌，因此可用于预防治疗碳水化合物或脂质代谢紊乱，包括糖尿病（1型和2型糖尿病）、前驱糖尿病和代谢综合征。
• Compounds and Compositions for Use in the Prevention and Treatment of Disorders of Fat Metabolism and Obesity
  申请人：Jette Lucie

  公开号：US20100048545A1

  公开（公告）日：2010-02-25

  The invention relates to 4-hydroxyisoleucine, isomers, analogs, lactones, salts, and prodrugs thereof, to processes for their preparation, and to pharmaceutical compositions comprising the same. More particularly, the invention relates to the use of those compounds in the prevention and treatment of disorders of fat metabolism and related syndromes. The invention further relates to the use of those compounds in the prevention and treatment of obesity and related syndromes including, but not limited to, the cosmetic treatment of a mammal in order to effect a cosmetically beneficial loss of body weight, and more particularly loss of body fat.

  本发明涉及4-羟基异亮氨酸、其同分异构体、类似物、内酯、盐和前药的制备方法，以及包含这些化合物的药物组合物。更具体地，本发明涉及这些化合物在预防和治疗脂肪代谢紊乱和相关综合症方面的用途。本发明还涉及这些化合物在预防和治疗肥胖和相关综合症方面的用途，包括但不限于美容治疗哺乳动物，以实现对体重，特别是体脂肪的美容有益的减少。
• N-alkylcarbamylalkanol sulfate or salt thereof, process for producing the same and detergent composition containing the same
  申请人：KAO CORPORATION

  公开号：EP0621265A1

  公开（公告）日：1994-10-26

  A N-alkylcarbamylalkanol sulfate or a salt thereof represented by the following general formula (1-1), a process for producing the same, and a detergent composition containing the same, which is useful as a detergent for hair, body or tableware and has not only excellent foaming power and detergency but also high safety: wherein R¹ represents a linear or branched alkyl or alkenyl group having 6 to 22 carbon atoms; R² represents an alkyl or alkenyl group having 1 to 22 carbon atoms or a hydrogen atom: R³ represents a linear or branched alkylene group having 1 to 5 carbon atoms; R⁴O represents an oxyalkylene group having 2 or 3 carbon atoms; Ma represents a hydrogen atom, an alkali metal atom, an ammonium group, etc.; and n represents a number between 0 and 20).

  一种由以下通式（1-1）表示的 N-烷基氨基甲酰基烷醇硫酸盐或其盐，一种生产该物质的工艺，以及一种含有该物质的洗涤剂组合物，它可用作头发、身体或餐具的洗涤剂，不仅具有出色的发泡力和去污力，而且安全性高： 其中 R¹ 代表具有 6 至 22 个碳原子的直链或支链烷基或烯基；R² 代表具有 1 至 22 个碳原子的烷基或烯基或氢原子：R³ 代表具有 1 至 5 个碳原子的直链或支链亚烷基；R⁴O 代表具有 2 或 3 个碳原子的氧亚烷基；Ma 代表氢原子、碱金属原子、铵基团等；n 代表 0 至 20 之间的数字)。
• Synthesis of glycols via transfer hydrogenation of alpha-functional esters with alcohols
  申请人：Eastman Chemical Company

  公开号：US10266467B2

  公开（公告）日：2019-04-23

  A transfer hydrogenation process for forming vicinal diols by hydrogenating 1,2-dioxygenated organic compounds using alcohols as the reducing agent instead of the traditional H2 gas. The transfer hydrogenation is carried out under milder conditions of temperature and pressure than is typical for ester hydrogenation with H2. The milder conditions of operation provide benefits, such as lower operating and capital costs for industrial scale production as well as savings in product purification due to the avoidance of by-products from exposure of reaction mixtures and products to high temperatures.

  利用醇类作为还原剂而不是传统的 H2 气体，通过氢化 1,2-二氧 化有机化合物形成沧烷二醇的转移氢化工艺。与使用 H2 进行酯加氢的典型方法相比，转移加氢是在较温和的温度和压力条件下进行的。较温和的操作条件带来了诸多好处，例如降低了工业规模生产的操作和资本成本，以及由于避免了反应混合物和产品暴露于高温而产生的副产品，从而节省了产品提纯费用。