(2E,4E)-5-{4-[Bis-(2-hydroxy-ethyl)-amino]-phenyl}-penta-2,4-dienal | 188676-44-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2E,4E)-5-{4-[Bis-(2-hydroxy-ethyl)-amino]-phenyl}-penta-2,4-dienal
• 英文别名: 5-{4-[Bis(2-hydroxyethyl)amino]phenyl}penta-2,4-dienal；5-[4-[bis(2-hydroxyethyl)amino]phenyl]penta-2,4-dienal
• CAS: 188676-44-0
• 化学式: C₁₅H₁₉NO₃
• 分子量: 261.321
• InChiKey: HMBSYYDTRGWUAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  60.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,3-二乙基-2-硫代巴比妥酸 、 (2E,4E)-5-{4-[Bis-(2-hydroxy-ethyl)-amino]-phenyl}-penta-2,4-dienal 以 乙醇 为溶剂， 反应 1.0h， 以94%的产率得到
  参考文献：
  名称：

  A convenient synthetic entry into aldehydes with extended conjugation

  摘要：

  Variable-length donor-acceptor polyenes 1-18 were synthesized. In the key step, a polyenal was appended to an aromatic donor through nucleophilic attack oi an organolithium reagent on a vinylogous amide. Yields of aldehydes and dialdehydes in the one-pot process ranged from 12-64% and depended upon number of repeat units (n=1-3) in the polyene chain. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00047-1
• 作为产物：
  描述：

  N,N-二羟乙基苯胺 在 N-溴代丁二酰亚胺(NBS) 、 正丁基锂 、 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 (2E,4E)-5-{4-[Bis-(2-hydroxy-ethyl)-amino]-phenyl}-penta-2,4-dienal
  参考文献：
  名称：

  A convenient synthetic entry into aldehydes with extended conjugation

  摘要：

  Variable-length donor-acceptor polyenes 1-18 were synthesized. In the key step, a polyenal was appended to an aromatic donor through nucleophilic attack oi an organolithium reagent on a vinylogous amide. Yields of aldehydes and dialdehydes in the one-pot process ranged from 12-64% and depended upon number of repeat units (n=1-3) in the polyene chain. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00047-1

文献信息

• A convenient synthetic entry into aldehydes with extended conjugation
  作者：Andrienne C. Friedli、Edward Yang、Seth R. Marder

  DOI：10.1016/s0040-4020(97)00047-1

  日期：1997.2

  Variable-length donor-acceptor polyenes 1-18 were synthesized. In the key step, a polyenal was appended to an aromatic donor through nucleophilic attack oi an organolithium reagent on a vinylogous amide. Yields of aldehydes and dialdehydes in the one-pot process ranged from 12-64% and depended upon number of repeat units (n=1-3) in the polyene chain. (C) 1997 Elsevier Science Ltd.