diethyl 2-hydroxy-2-(4-nitrophenyl)propylphosphonate | 1334049-15-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diethyl 2-hydroxy-2-(4-nitrophenyl)propylphosphonate
• 英文别名: 1-[Diethoxy(oxido)phosphaniumyl]-2-(4-nitrophenyl)propan-2-ol；1-[diethoxy(oxido)phosphaniumyl]-2-(4-nitrophenyl)propan-2-ol
• CAS: 1334049-15-8
• 化学式: C₁₃H₂₀NO₆P
• 分子量: 317.279
• InChiKey: QZBRGCMTFUHBRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  phosphorohydrazidic acid diethyl ester 、 1-isopropenyl-4-nitro-benzene 在 铁酞菁 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以39%的产率得到diethyl 2-hydroxy-2-(4-nitrophenyl)propylphosphonate
  参考文献：
  名称：

  Synthesis of β-hydroxyphosphonates by iron-catalyzed oxidative addition of phosphonyl radicals to alkenes

  摘要：

  Phosphorohydrazidates have been shown to work as radical precursors by iron-catalyzed aerobic oxidation to generate corresponding phosphonyl radicals. Generated radicals cause intermolecular addition to various alkenes in the presence of molecular oxygen to give beta-hydroxyphosphonate compounds in good yield. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.07.026

文献信息

• Synthesis of β-hydroxyphosphonates by iron-catalyzed oxidative addition of phosphonyl radicals to alkenes
  作者：Tsuyoshi Taniguchi、Atsushi Idota、Shin’ichi Yokoyama、Hiroyuki Ishibashi

  DOI：10.1016/j.tetlet.2011.07.026

  日期：2011.9

  Phosphorohydrazidates have been shown to work as radical precursors by iron-catalyzed aerobic oxidation to generate corresponding phosphonyl radicals. Generated radicals cause intermolecular addition to various alkenes in the presence of molecular oxygen to give beta-hydroxyphosphonate compounds in good yield. (C) 2011 Elsevier Ltd. All rights reserved.