Asparagylglycine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Asparagylglycine
• 英文别名: 2-[(2,4-diamino-4-oxobutanoyl)amino]acetic acid
• 化学式: C₆H₁₁N₃O₄
• 分子量: 189.17
• InChiKey: KLKHFFMNGWULBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.2
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  136
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers
  申请人：New York Blood Center, Inc.

  公开号：EP0154902A2

  公开（公告）日：1985-09-18

  A hepatitis B vaccine containing a peptide with an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus. The vaccine being free of an amino acid sequence corresponding to the naturally occuring evelope proteins of hepatitis B virus and a physiologically acceptable diluent. The peptide being free or linked to a carrier. The carrier being a conventional carrier or a novel carrier including a lipid vesicle stabilized by cross-linking and having covalently bonded active sites on the outer surface thereon. Such novel carrier being useful not only to link the novel peptide containing an amino acid chain with amino acids within the pre-S gene coded region of the surface antigen of hepatitis B virus, but can also be used to bind synthetic peptide analogues of other viral proteins, as well as bacterial, allergen and parasitic proteins of man and animals. The peptides of the invention can be utilized in diagnostics for the detection of antigens and antibodies.

  一种乙型肝炎疫苗，含有乙型肝炎病毒包膜前 S 基因编码区内至少六个连续氨基酸链的多肽。该疫苗不含与天然存在的乙型肝炎病毒包膜蛋白相对应的氨基酸序列和生理上可接受的稀释剂。多肽不含载体或与载体相连。载体可以是传统载体，也可以是新型载体，包括通过交联稳定的脂质囊泡，其外表面具有共价键活性位点。这种新型载体不仅可用于将含有氨基酸链的新型多肽与乙型肝炎病毒表面抗原前 S 基因编码区内的氨基酸连接起来，还可用于结合其他病毒蛋白的合成多肽类似物，以及人和动物的细菌、过敏原和寄生虫蛋白。本发明的多肽可用于抗原和抗体的诊断检测。
• Complex immunogen containing synthetic peptides
  申请人：New York Blood Center, Inc.

  公开号：EP0244719A2

  公开（公告）日：1987-11-11

  A complex immunogen comprising a core structure and multiple copies of one or more synthetic distinct peptides covalently linked to the core structure, the core structure comprising a saponin derivative and an organic compound having 12 to 24 carbon atoms or a hydrophobic polypeptide having an active moiety selected from the group consisting of -COOH, -CHO, -NH2 and -SH.

  一种复合免疫原，包括一个核心结构和与核心结构共价连接的一份或多份合成的不同肽，核心结构包括皂素衍生物和具有 12 至 24 个碳原子的有机化合物或具有选自-COOH、-CHO、-NH2 和-SH 所组成的组的活性分子的疏水多肽。
• Pre-s gene codes peptide hepatitis b immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers
  申请人：New York Blood Center, Inc.

  公开号：EP0243913A2

  公开（公告）日：1987-11-04

  A hepatitis B vaccine containing a peptide with an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis 8 virus. The vaccine being free of an amino acid sequence corresponding to the naturally occurring envelope proteins of hepatitis B virus and a physiologically acceptable diluent. The peptide being free or linked to a carrier. The carrier being a conventional carrier or a novel carrier including a lipid vesicle stabilized by cross-linking and having covalently bonded active sites on the outer surface thereon. Such novel carrier being useful not only to link the novel peptide containing an amino acid chain with amino acids within the pre-S gene coded region of the surface antigen of hepatitis B virus, but can also be used to bind synthetic peptide analogues of other viral proteins, as well as bacterial, allergen and parasitic proteins of man and animals. The peptides of the invention can be utilized in diagnostics for the detection of antigens and antibodies.

  一种乙型肝炎疫苗，其中含有一种多肽，该多肽的氨基酸链至少有六个连续的氨基酸位于八型肝炎病毒包膜的前 S 基因编码区内。该疫苗不含与天然存在的乙型肝炎病毒包膜蛋白相对应的氨基酸序列和生理上可接受的稀释剂。多肽不含载体或与载体相连。载体可以是传统载体，也可以是新型载体，包括通过交联稳定的脂质囊泡，其外表面具有共价键活性位点。这种新型载体不仅可用于将含有氨基酸链的新型多肽与乙型肝炎病毒表面抗原前 S 基因编码区内的氨基酸连接起来，还可用于结合其他病毒蛋白的合成多肽类似物，以及人和动物的细菌、过敏原和寄生虫蛋白。本发明的多肽可用于抗原和抗体的诊断检测。
• Species-specific epitode of chlamydia trachomatis and antibodies that recognize the same
  申请人：MILES INC.

  公开号：EP0348725A2

  公开（公告）日：1990-01-03

  An antibody against a common epitope of Chlamydia trachomatis, the antibody produced by immunizing an animal against a peptide, the peptide having at least five amino acids, said peptide consisting essentially of at least four amino acids having a sequence position of I to XII of the following epitope-specific natural sequence: wherein said at least four amino acids are in their sequence position, but need not be contiguous to one another, the remaining amino acids being in said natural sequence or being immunogenic equivalents to the amino acids in the natural sequence, said peptide having no more than fifteen consecutive amino acids of natural Chlamydia trachomatis antigen and isolating antibody produced thereby.

  一种抗沙眼衣原体共同表位的抗体，该抗体通过对动物进行多肽免疫而产生，所述多肽具有至少五个氨基酸，所述多肽基本上由至少四个氨基酸组成，这些氨基酸具有以下表位特异性天然序列的 I 至 XII 序列位置：其中所述至少四个氨基酸在其序列位置上，但不必彼此毗连，其余氨基酸在所述天然序列中，或与天然序列中的氨基酸具有免疫原性等价，所述多肽具有不超过十五个天然沙眼衣原体抗原的连续氨基酸，并由此产生分离抗体。
• Improved immunogens containing peptides with an attached hydrophobic tail for adsorption to hepatitis B virus surface antigen
  申请人：New York Blood Center, Inc.

  公开号：EP0326109A2

  公开（公告）日：1989-08-02

  An immunogenic complex comprising a peptide containing a hydrophobic tail, the peptide being adsorbed to hepatitis B virus surface antigen via the hydrophobic tail. Such complex in a immunogenically effective amount when administered with a physiologically acceptable diluent and an adjuvant can serve as a vaccine.

  一种免疫原复合物，由含有疏水尾部的多肽组成，多肽通过疏水尾部吸附在乙型肝炎病毒表面抗原上。这种复合物与生理上可接受的稀释剂和佐剂一起使用时，其免疫有效量可用作疫苗。