Phenylmercaptomethanphosphonsaeure | 89854-56-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: Phenylmercaptomethanphosphonsaeure
• 英文别名: Phenylsulfanylmethyl-phosphonic acid；phenylsulfanylmethylphosphonic acid
• CAS: 89854-56-8
• 化学式: C₇H₉O₃PS
• 分子量: 204.186
• InChiKey: JPIROWHTPUZLPV-UHFFFAOYSA-N

物化性质

• 熔点：
  242 °C(Solv: water (7732-18-5))
• 沸点：
  401.1±47.0 °C(Predicted)
• 密度：
  1.44±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  82.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Phenylmercaptomethanphosphonsaeure 在 双氧水 作用下， 以 溶剂黄146 为溶剂， 生成 Phenylsulfon-methanphosphonsaeure
  参考文献：
  名称：

  KREUTZKAMP; MENGEL, Archiv der Pharmazie, 1962, vol. 295 /67, p. 773 - 779

  摘要：

  DOI：
• 作为产物：
  描述：

  氯甲基苯硫醚 在 碘代三甲硅烷 作用下， 以 二氯甲烷 为溶剂， 生成 Phenylmercaptomethanphosphonsaeure
  参考文献：
  名称：

  A nonhydrolyzable analogue of phosphotyrosine, and related aryloxymethano- and aryloxyethano-phosphonic acids as motifs for inhibition of phosphatases

  摘要：

  Nonhydrolyzable analogues of both stereoisomers of phosphotyrosine, and a series of related aryloxy (or thio) methyl and aryloxy (or thio) ethyl phosphonic acids of the general formula RX-(CH2) -PO3H2 (where X = O or S and n = 1 or 2), have been tested as nonhydrolyzable mimetics of phosphatase substrates. These compounds were tested against a panel of phosphatases (two alkaline phosphatases, a protein-tyrosine phosphatase, and two serine/threonine phosphatases) with different active site motifs. The compounds exhibit competitive inhibition toward all enzymes tested, with the best inhibition expressed toward the Ser/Thr phosphatases. The stereoisomers of the phosphotyrosine analogues exhibited an unexpected difference in their inhibitory properties toward the protein-tyrosine phosphatase from Yersinia. The K-i for the D isomer is 33-fold lower than that of the (L) isomer, and is more than an order of magnitude lower than the reported K, of the substrate L-phosphotyrosine. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.09.008

文献信息

• POLYMER ELECTROLYTE COMPOSITION AND POLYMER ELECTROLYTE MEMBRANE, MEMBRANE-ELECTROLYTE ASSEMBLY, AND SOLID POLYMER FUEL CELL USING SAME
  申请人：Toray Industries, Inc.

  公开号：EP3131145A1

  公开（公告）日：2017-02-15

  [Problem] To provide: a polymer electrolyte composition that has excellent chemical stability that makes it possible to withstand a strong oxidizing atmosphere during fuel cell operation, that makes it possible to achieve excellent protonic conductivity under low humidity conditions, excellent mechanical strength, and excellent physical durability, and that is highly practical; and a polymer electrolyte membrane, a membrane-electrode assembly, and a solid polymer fuel cell that use the polymer electrolyte composition. [Solution] A polymer electrolyte composition that comprises at least an ionic group-containing polymer (A), an organic phosphorus-based additive (C), and a nitrogen-containing heteroaromatic ring system additive (D) and that is characterized by the nitrogen-containing heteroaromatic ring system additive (D) comprising at least three nitrogen-containing heteroaromatic rings within a molecule thereof. In addition, the polymer electrolyte membrane, the catalyst layer-equipped electrolyte membrane, the membrane-electrode assembly, and the solid polymer fuel cell of the present invention are characterized by being configured using the polymer electrolyte composition.

  问题 提供一种聚合物电解质组合物，该组合物具有优异的化学稳定性，能够在燃料电池运行期间耐受强氧化性气氛，能够在低湿度条件下实现优异的质子电导率，具有优异的机械强度和优异的物理耐久性，并且具有很高的实用性；以及一种使用该聚合物电解质组合物的聚合物电解质膜、膜电极组件和固体聚合物燃料电池。[解决方案]一种聚合物电解质组合物，它至少包含一种含离子基团的聚合物（A）、一种有机磷基添加剂（C）和一种含氮杂芳香族环系添加剂（D），其特征在于含氮杂芳香族环系添加剂（D）在其分子内至少包含三个含氮杂芳香族环。此外，本发明的聚合物电解质膜、配备催化剂层的电解质膜、膜电极组件和固体聚合物燃料电池的特征在于使用聚合物电解质组合物进行配置。
• PROCESS FOR PREPARING AROMATIC THIOPHENYL KETONES
  申请人：Ciba Holding Inc.

  公开号：EP1799638B1

  公开（公告）日：2008-07-30
• A nonhydrolyzable analogue of phosphotyrosine, and related aryloxymethano- and aryloxyethano-phosphonic acids as motifs for inhibition of phosphatases
  作者：Subashree Iyer、Jarod M. Younker、Przemyslaw G. Czyryca、Alvan C. Hengge

  DOI：10.1016/j.bmcl.2004.09.008

  日期：2004.12

  Nonhydrolyzable analogues of both stereoisomers of phosphotyrosine, and a series of related aryloxy (or thio) methyl and aryloxy (or thio) ethyl phosphonic acids of the general formula RX-(CH2) -PO3H2 (where X = O or S and n = 1 or 2), have been tested as nonhydrolyzable mimetics of phosphatase substrates. These compounds were tested against a panel of phosphatases (two alkaline phosphatases, a protein-tyrosine phosphatase, and two serine/threonine phosphatases) with different active site motifs. The compounds exhibit competitive inhibition toward all enzymes tested, with the best inhibition expressed toward the Ser/Thr phosphatases. The stereoisomers of the phosphotyrosine analogues exhibited an unexpected difference in their inhibitory properties toward the protein-tyrosine phosphatase from Yersinia. The K-i for the D isomer is 33-fold lower than that of the (L) isomer, and is more than an order of magnitude lower than the reported K, of the substrate L-phosphotyrosine. (C) 2004 Elsevier Ltd. All rights reserved.
• KREUTZKAMP; MENGEL, Archiv der Pharmazie, 1962, vol. 295 /67, p. 773 - 779
  作者：KREUTZKAMP、MENGEL

  DOI：——

  日期：——