methyl (E)-3-(4'-methoxy[1,1'-biphenyl]-4-yl)acrylate | 918332-95-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl (E)-3-(4'-methoxy[1,1'-biphenyl]-4-yl)acrylate
• 英文别名: methyl (E)-3-(4'-methoxybiphenyl-4-yl)-acrylate；methyl 3-(4-methoxybiphenylyl)acrylate；methyl (E)-3-[4-(4-methoxyphenyl)phenyl]prop-2-enoate
• CAS: 918332-95-3
• 化学式: C₁₇H₁₆O₃
• 分子量: 268.312
• InChiKey: PNBRNXPLDBYJLV-LFYBBSHMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  O-(四氢-2H-吡喃-2-基)羟基胺 、 methyl (E)-3-(4'-methoxy[1,1'-biphenyl]-4-yl)acrylate 在 sodium hexamethyldisilazane 、 水 、 氯化铵 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 (E)-3-(4'-methoxybiphenyl-4-yl)-N-(tetrahydropyran-2-yloxy)-acrylamide
  参考文献：
  名称：

  WO2007/383

  摘要：

  公开号：
• 作为产物：
  描述：

  3-(4-溴苯基)-2-丙酸甲酯 、 4-甲氧基苯硼酸 在 四(三苯基膦)钯 sodium carbonate 作用下， 以 乙醇 、 水 、 甲苯 为溶剂， 反应 2.0h， 生成 methyl (E)-3-(4'-methoxy[1,1'-biphenyl]-4-yl)acrylate
  参考文献：
  名称：

  WO2007/383

  摘要：

  公开号：

文献信息

• Isoxazole derivatives and methods of treating nitric oxide mediated diseases
  申请人：Shaw Jiajiu

  公开号：US20060223873A1

  公开（公告）日：2006-10-05

  A series of isoxazole derivatives and methods of suppressing, inhibiting, or preventing disorders mediated by nitric oxide (NO) and/or proinflammatory cytokines, such as TNF-α (tumor necrosis factor alpha), IL-1 (interlukin-1), and IL-6, are described.

  本文描述了一系列异唑啉衍生物及其抑制、抑制或预防由一氧化氮(NO)和/或促炎细胞因子引起的疾病的方法，例如TNF-α（肿瘤坏死因子α）、IL-1（白细胞介素1）和IL-6。
• Biphenyl and Naphthyl-Phenyl Hydroxamic Acid Derivatives
  申请人：Pisano Claudio

  公开号：US20080319082A1

  公开（公告）日：2008-12-25

  Biphenyl and phenyl-naphthyl compounds bearing a hydroxamic group, which are endowed with antitumour, and anti-angiogenic activity These compounds are therefore particularly useful for the treatment of drug-resistant tumours.

  苯基联苯和苯基萘化合物带有羟肟基，具有抗肿瘤和抗血管生成活性。因此，这些化合物特别适用于治疗耐药性肿瘤。
• Auto-Tandem Copper-Catalyzed Carboxylation of Undirected Alkenyl C–H Bonds with CO₂ by Harnessing β-Hydride Elimination
  作者：Harekrishna Sahoo、Liang Zhang、Jianhua Cheng、Masayoshi Nishiura、Zhaomin Hou

  DOI：10.1021/jacs.2c10754

  日期：2022.12.28

  The exploration into challenging scenarios of the application of elementary reactions offers excellent opportunities for the development of unique transformations under organometallic catalysis. As a ubiquitous reaction of metal alkyl complexes, β-hydride elimination plays a crucial role in a number of important catalytic transformations. However, its functions in these catalytic cycles are limited

  对基本反应应用的挑战性场景的探索为在有机金属催化下发展独特的转化提供了极好的机会。作为金属烷基配合物的普遍反应，β-氢化物消除在许多重要的催化转化中起着至关重要的作用。然而，它在这些催化循环中的功能仅限于释放烯烃产物或通过进一步迁移插入产生异构化中间体。在此，我们报道了 β-氢化物消除的精确操作能够实现自动串联铜催化，用于无向烯基 C-H 键与 CO 2的羧化。在这种转化中，促进了烷基铜中间体的 β-氢化物消除，同时它与 CO 反应2被压制。生成的氢化铜反过来与 CO 2反应，提供多任务催化剂的途径，这使得 C-H 键在两个机械上不同的催化循环中串联硼化/羧化。
• Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors
  作者：Sabrina Dallavalle、Raffaella Cincinelli、Raffaella Nannei、Lucio Merlini、Gabriella Morini、Sergio Penco、Claudio Pisano、Loredana Vesci、Marcella Barbarino、Valentina Zuco

  DOI：10.1016/j.ejmech.2008.11.005

  日期：2009.5

  A series of hydroxamic acid-based histone deacetylase (HDAC) inhibitors were designed on the basis of a model of the HDAC2 binding site and synthesized. They are characterized by a cinnamic spacer, capped with a substituted phenyl group. Modifications of the spacer are also reported. In an in vitro assay with the isoenzyme HDAC2, a good correlation of the activity with the docking energy was found. In human ovarian carcinoma IGROV-1 cells, selected compounds produced significant acetylation of p53 and alpha-tubulin. Most compounds showed an antiproliferative activity comparable to that of SAHA. At equitoxic concentrations, the tested compounds were more effective than SAHA in inducing apoptotic cell death. Compounds selected for in vivo evaluation exhibited a significant antitumor activity on three tumor models at well tolerated doses, thus suggesting a good therapeutic index. (C) 2008 Elsevier Masson SAS. All rights reserved.
• US7291743B2
  申请人：——

  公开号：US7291743B2

  公开（公告）日：2007-11-06