Cyclohexen-(1)-yl-malonsaeure | 708-69-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Cyclohexen-(1)-yl-malonsaeure
• 英文别名: cyclohex-1-enyl-malonic acid；Cyclohex-1-enyl-malonsaeure；Cyclohexenylmalonic acid；2-(cyclohexen-1-yl)propanedioic acid
• CAS: 708-69-0
• 化学式: C₉H₁₂O₄
• 分子量: 184.192
• InChiKey: GCIIBLFSSCAMID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Cyclohexen-(1)-yl-malonsaeure 生成 1-环己烯基乙酸
  参考文献：
  名称：

  Kon; Speight, Journal of the Chemical Society, 1926, p. 2733

  摘要：

  DOI：
• 作为产物：
  描述：

  Cyclohexenylmalonsaeure-diethylester 在 氢氧化钾 、 乙醇 作用下， 生成 Cyclohexen-(1)-yl-malonsaeure
  参考文献：
  名称：

  Kon; Speight, Journal of the Chemical Society, 1926, p. 2733

  摘要：

  DOI：

文献信息

• COMPOUNDS USEFUL AS MODULATORS OF TRPM8
  申请人：SENOMYX, INC.

  公开号：US20150376136A1

  公开（公告）日：2015-12-31

  The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formulae (Ia), (Ib) and (Ic), and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.

  本发明包括作为TRPM8调节剂有用的化合物，例如式(Ia)、(Ib)和(Ic)的化合物，以及其亚属和种类；含有这些化合物的个人产品；以及利用这些化合物和个人产品，特别是利用增加或诱导化学感觉，如凉爽或冷感觉。
• MALONATE DECARBOXYLASES FOR INDUSTRIAL APPLICATIONS
  申请人：Hauer Bernhard

  公开号：US20100311037A1

  公开（公告）日：2010-12-09

  The present invention relates to a method for the enzymatic decarboxylation of malonic acid (propanedioic acid) derivatives catalyzed by enzymes structurally and/or functionally related to arylmalonate decarboxylase (AMDase) as isolated from microorganisms of the genus Bordetella . The present invention also relates to novel enzymes with a decarboxylase activity, useful for performing the claimed method, mutants thereof, corresponding coding sequences and expression systems, methods of preparing said novel enzymes, and screening methods for obtaining further suitable enzymes also having said decarboxylase activity.

  本发明涉及一种利用结构和/或功能与芳基丙二酸脱羧酶（AMDase）相关的酶催化菌属Bordetella微生物中分离的方法，对丙二酸（丙二酸）衍生物进行酶促脱羧的方法。本发明还涉及具有脱羧酶活性的新酶，用于执行所述方法的突变体，相应的编码序列和表达系统，制备所述新酶的方法以及用于获得具有所述脱羧酶活性的进一步合适酶的筛选方法。
• New malonate decarboxylases for industrial applications
  申请人：BASF SE

  公开号：EP2565273A1

  公开（公告）日：2013-03-06

  The present invention relates to a method for the enzymatic decarboxylation of malonic acid (propanedioic acid) derivatives catalyzed by enzymes structurally and/or functionally related to arylmalonate decarboxylase (AMDase) as isolated from microorganisms of the genus Bordetella. The present invention also relates to novel enzymes with a decarboxylase activity, useful for performing the claimed method, mutants thereof, corresponding coding sequences and expression systems, methods of preparing said novel enzymes, and screening methods for obtaining further suitable enzymes also having said decarboxylase activity.

  本发明涉及一种丙二酸(丙二酸)衍生物的酶促脱羧方法，该方法由结构上和/或功能上与芳基丙二酸脱羧酶(AMDase)有关的酶催化，这些酶是从博德特氏菌属微生物中分离出来的。本发明还涉及具有脱羧酶活性的新型酶，可用于实施所要求的方法、其突变体、相应的编码序列和表达系统、制备所述新型酶的方法，以及获得同样具有所述脱羧酶活性的其他合适酶的筛选方法。
• Compounds useful as modulators of TRPM8
  申请人：Firmenich Incorporated

  公开号：US10421727B2

  公开（公告）日：2019-09-24

  The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formulae (Ia), (Ib) and (Ic), and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.

  本发明包括可用作 TRPM8 调节剂的化合物，如式（Ia）、（Ib）和（Ic）化合物及其亚属和种；含有这些化合物的个人用品；以及这些化合物和个人用品的用途，特别是增加或诱导化学麻醉感觉的用途，如冷却或冷感。
• Diamides of methane-1:1-dicarboxylic acids
  申请人：GEIGY AG J R

  公开号：US02447196A1

  公开（公告）日：1948-08-17