6-methyl-3-oxo-2,3,4,5-tetrahydro-pyridazine-4-carboxylic acid hydrazide | 98485-04-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-methyl-3-oxo-2,3,4,5-tetrahydro-pyridazine-4-carboxylic acid hydrazide
• 英文别名: 6-Methyl-3-oxo-2,3,4,5-tetrahydro-pyridazin-4-carbonsaeure-hydrazid；3-methyl-6-oxo-4,5-dihydro-1H-pyridazine-5-carbohydrazide
• CAS: 98485-04-2
• 化学式: C₆H₁₀N₄O₂
• 分子量: 170.171
• InChiKey: NZYLJGFXWJPRCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  96.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-methyl-3-oxo-2,3,4,5-tetrahydro-pyridazine-4-carboxylic acid hydrazide 、 alkaline earth salt of/the/ methylsulfuric acid 生成 acetonyl-malonic acid
  参考文献：
  名称：

  Bilateral Squamous Cell Carcinoma of the External Auditory Canals

  摘要：

  AbstractObjectives To report a case of bilateral squamous cell carcinoma of the external auditory canals and to present a management algorithm for this difficult clinical scenario.Study Design Case report and literature review.Methods The study comprises a case report of a 69‐year‐old man who initially presented with complaints of bilateral otorrhea, left‐sided otalgia, and a left‐sided hearing loss. Following attempted treatment of a presumed case of otitis externa, biopsy of both external auditory canals revealed squamous cell carcinoma. A computed tomography scan demonstrated marked abnormal soft tissue in the left external auditory canal with no bony erosion and thickening of the soft tissue in the right external auditory canal.Results The left‐sided lesion required a lateral temporal bone resection, a partial superficial and deep‐lobe parotidectomy, and postoperative irradiation. The right‐sided lesion was more limited and was managed with a lateral temporal bone resection and tympanoplasty for hearing preservation.Conclusions Bilateral squamous cell carcinoma of the external auditory canals is an extremely uncommon but aggressive malignancy that may present with symptoms similar to a case of otitis externa, and this can result in delays in proper diagnosis. Early recognition is essential because management and prognosis are determined by the extent of the lesion.

  DOI：

  10.1097/00005537-200206000-00012
• 作为产物：
  描述：

  乙酰甲基丙二酸二乙酯 在 乙醇 、 一水合肼 作用下， 生成 6-methyl-3-oxo-2,3,4,5-tetrahydro-pyridazine-4-carboxylic acid hydrazide
  参考文献：
  名称：

  Gault; Salomon, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1922, vol. 175, p. 275

  摘要：

  DOI：

文献信息

• Gault; Salomon, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1922, vol. 175, p. 275
  作者：Gault、Salomon

  DOI：——

  日期：——
• Bilateral Squamous Cell Carcinoma of the External Auditory Canals
  作者：Stephen G. Wolfe、Stephen Y. Lai、Douglas C. Bigelow

  DOI：10.1097/00005537-200206000-00012

  日期：2002.6

  AbstractObjectives To report a case of bilateral squamous cell carcinoma of the external auditory canals and to present a management algorithm for this difficult clinical scenario.Study Design Case report and literature review.Methods The study comprises a case report of a 69‐year‐old man who initially presented with complaints of bilateral otorrhea, left‐sided otalgia, and a left‐sided hearing loss. Following attempted treatment of a presumed case of otitis externa, biopsy of both external auditory canals revealed squamous cell carcinoma. A computed tomography scan demonstrated marked abnormal soft tissue in the left external auditory canal with no bony erosion and thickening of the soft tissue in the right external auditory canal.Results The left‐sided lesion required a lateral temporal bone resection, a partial superficial and deep‐lobe parotidectomy, and postoperative irradiation. The right‐sided lesion was more limited and was managed with a lateral temporal bone resection and tympanoplasty for hearing preservation.Conclusions Bilateral squamous cell carcinoma of the external auditory canals is an extremely uncommon but aggressive malignancy that may present with symptoms similar to a case of otitis externa, and this can result in delays in proper diagnosis. Early recognition is essential because management and prognosis are determined by the extent of the lesion.