2-异丙烯基-6-甲基-苯酚 | 53621-45-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-异丙烯基-6-甲基-苯酚
• 英文名称: S29
• 英文别名: isopropenyl cresol；2-Propen-2-yl-6-methylphenol；2-Isopropenyl-6-methyl-phenol；2-Oxy-1-methyl-3-isopropenyl-benzol；β-(2-Oxy-3-methyl-phenyl)-propylen；2-Methyl-6-(prop-1-en-2-yl)phenol；2-methyl-6-prop-1-en-2-ylphenol
• CAS: 53621-45-7
• 化学式: C₁₀H₁₂O
• 分子量: 148.205
• InChiKey: RKBLZKOIUZETQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-异丙烯基-6-甲基-苯酚 在 乙醇 、 氢碘酸 、 sodium 作用下， 生成 2-甲基-6-异丙基苯酚
  参考文献：
  名称：

  Behal; Tiffeneau, Bulletin de la Societe Chimique de France, 1908, vol. <4> 3, p. 730

  摘要：

  DOI：
• 作为产物：
  描述：

  3-甲基水杨酸 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 26.0h， 生成 2-异丙烯基-6-甲基-苯酚
  参考文献：
  名称：

  铱催化跨分子内碳-碳双键的甲基醚的C（sp3）-H加成反应，生成2,3-二氢苯并呋喃

  摘要：

  跨碳-碳双键的O-甲基C（sp 3）-H键的分子内加成发生在铱催化的甲基2-（丙烯-2-基）苯基醚的反应中。Ir /（S）-DTBM-SEGPHOS催化剂可在110-135°C的甲苯中有效地促进反应，得到3,3-二甲基-2-3，二氢苯并呋喃。对映选择性的C（sp 3）-H加成反应是通过甲基2-（1-甲硅烷氧基乙烯基）苯基醚的反应实现的，从而提供了对映体富集的3-羟基-2,3-二氢苯并呋喃衍生物，其ee高达96％。

  DOI：

  10.1002/adsc.201900749

文献信息

• Role of Activated Protein C Resistance in Left Atrial Thrombogenesis in Patients with Mitral Stenosis
  作者：Ismet Hisar、Mehmet Ileri、Ertan Yetkin、Ramazan Atak、Kubilay Senen、Feridun Kosar、Semra Dundar、Deniz Demirkan

  DOI：10.1177/000331970005101008

  日期：2000.10

  Activated protein C resistance (APC-R) is the most common inherited cause of clinically apparent venous thromboembolism. Previous data indicate that left atrial thrombus (LAT) formation is a common complication in mitral stenosis (MS) and a hypercoagulable state exists in these patients. The aim of this study was to invastigate the association between APC-R and LAT formation in patients with MS. Seventy-seven consecutive patients with rheumatic MS were included in this study. Transesophageal echocardiography was performed on all patients to assess the presence of any thrombus or spontaneous echo contrast (LASEC) in the left atrial cavity or appendage. Thirty four of the patients had LAT and 43 did not. Prevelance of APC-R was smiliar between the two groups of patients with and without LAT (23% vs 16%, p=0.425). LAT(+) patients had higher incidence of atrial fibrillation (AF, 74% vs 51%, p=0.046) and LASEC (71% vs 19%, p<0.001) compared to LAT(-) patients. On multivariate regression analysis, only the presence of LASEC achieved statistical significance as an independent risk factor for LAT formation (p=0.0001, odds ratio=9.589, 95% confidence interval [CI] =3.143-29.251). Because on (continued on next page) univariate analysis both LASEC and AF were associated with LAT, we also compared the prevelance of APC-R in the subgroups of patients who have these risk factors with and without LAT. There was a correlation between the presence of APC-R and LAT in the AF(+) subgroup of MS patients (p=0.033, odds ratio=8.167, 95% CI=1.001-72.812). However, the presence of APC-R was not associated with the increased risk of LAT in LASEC(+) patients (p=0.217, odds ratio =1.200, 95% CI=1.003-1.435). Although the presence of APC-R itself is not an independent risk factor for LAT formation in MS, it may increase the risk of LAT when present in combination with AF (as an additional risk factor) in these patients.

  激活蛋白C抵抗（APC-R）是临床明显的静脉血栓栓塞最常见的遗传性原因。先前的数据表明，左心房血栓（LAT）形成是二尖瓣狭窄（MS）的常见并发症，并且这些患者存在高凝状态。本研究旨在调查APC-R与MS患者中LAT形成之间的关联。本研究纳入了77例风湿性MS连续患者。对所有患者进行食管超声心动图检查，评估左心房腔或心耳中是否存在任何血栓或自发性回声对比（LASEC）。其中34例患者有LAT，43例没有。两组患者中APC-R的患病率相似（23% vs 16%，p=0.425）。LAT（+）患者与LAT（-）患者相比，房颤（AF）发生率更高（74% vs 51%，p=0.046），LASEC发生率更高（71% vs 19%，p<0.001）。多元回归分析显示，只有LASEC的存在在LAT形成中达到统计学意义上的独立风险因素（p=0.0001，比值比=9.589，95%置信区间[CI]=3.143-29.251）。因为在单变量分析中，LASEC和AF都与LAT相关，我们还比较了这些风险因素存在与不存在的子组中APC-R的患病率。在MS患者的AF（+）亚组中，APC-R的存在与LAT之间存在相关性（p=0.033，比值比=8.167，95% CI=1.001-72.812）。然而，在LASEC（+）患者中，APC-R的存在与LAT增加风险无关（p=0.217，比值比=1.200，95% CI=1.003-1.435）。尽管APC-R的存在本身不是MS中LAT形成的独立风险因素，但当与AF（作为额外风险因素）结合存在时，可能会增加这些患者LAT的风险。
• Coronary Artery-Left Ventricle Fistula Complicating Balloon Angioplasty
  作者：Takashi Takenaka、Masashi Horimoto、Kei-ichi Igarashi、Hitoki Inoue、Hitoshi Sakuragi

  DOI：10.1177/000331970005101012

  日期：2000.10

  The authors describe a coronary artery fistula complicated balloon angioplasty. The proximal left anterior descending coronary artery was dilated, but a septal branch was occluded by thrombus. Angioplasty was used on the septal branch, but a pseudoaneurysm communicating with the left ventricle occurred. Follow-up angiography revealed spon taneous closure of the fistula.

  作者描述了一种冠状动脉瘘管并发球囊扩张术的情况。近端左前降冠状动脉被扩张，但一个中隔支被血栓闭塞。对中隔支进行了血管成形术，但出现了与左心室相通的假性动脉瘤。随访血管造影显示瘘管自发闭合。
• Photoresist composition
  申请人：Kamabuchi Akira

  公开号：US10377692B2

  公开（公告）日：2019-08-13

  A photoresist composition comprising a resin which comprises a structural unit derived from a compound having an acid-labile group and which is insoluble or poorly soluble in an alkali aqueous solution but becomes soluble in an alkali aqueous solution by the action of an acid, an acid generator and a compound represented by the formula (I′): wherein R51, R52, R53 and R54 independently each represent a C1-C8 alkyl group, and A11 represents a C3-C36 divalent saturated cyclic hydrocarbon group which can contain one or more heteroatoms and which have one or more substituents or a C6-C20 divalent aromatic hydrocarbon group which can contain one or more heteroatoms and which have one or more substituents.

  一种光阻组合物，包括以下成分：由含有酸敏感基团的化合物衍生的结构单元构成的树脂，该树脂在碱性水溶液中不溶或溶解性差，但在酸的作用下变得可溶于碱性水溶液；酸发生剂；以及由下式（I'）表示的化合物：其中，R51、R52、R53和R54各自独立地表示C1-C8烷基；A11表示一个C3-C36的二价饱和环烃基，该基团可以含有一个或多个杂原子，并且可以具有一个或多个取代基，或者表示一个C6-C20的二价芳香族烃基，该基团可以含有一个或多个杂原子，并且可以具有一个或多个取代基。
• 3-phenoxy-4-pyridazinol derivatives and herbicide composition containing the same
  申请人：Tsukamoto Yoshihisa

  公开号：US20050037925A1

  公开（公告）日：2005-02-17

  A compound represented by the formula: [wherein R 1 represents a hydrogen atom, a halogen, atom, alkyl group, etc., R 2 represents a hydrogen atom, a halogen atom, alkyl group, etc., R 3 , R 4 , R 5 , R 6 and R 7 each independently represent a hydrogen atom, a halogen atom, a substitutable alkyl group, a substitutable alkenyl group, alkynyl group, a substituteable cycloalkyl group, etc., or R 3 , R 4 , R 5 , R 6 and R 7 may form a ring which may be substituted, which is formed by the adjacent two of them with carbon atoms to which the respective substituents are bonded, m and n each independently represent 0 or 1.] a salt thereof, an ester derivative thereof and an agricultural chemical containing the same as an effective ingredient, and a herbicidal composition containing the compound and a second herbicidally active compound as effective ingredients.

  一种化合物由以下式子表示：[其中R1代表氢原子，卤素原子，烷基团等，R2代表氢原子，卤素原子，烷基团等，R3，R4，R5，R6和R7各自独立地代表氢原子，卤素原子，可替换的烷基团，可替换的烯基团，炔基团，可替换的环烷基团等，或R3，R4，R5，R6和R7可以形成一个环，该环可以被取代，该环由相邻的两个碳原子形成，这些碳原子与相应的取代基团相连，m和n各自独立地代表0或1。]其盐，酯衍生物及含有该化合物为有效成分的农药，以及含有该化合物和第二种草甘膦活性化合物为有效成分的除草剂组合物。
• 3-Phenoxy-4-pyridazinol derivatives and herbicidal composition containing the same
  申请人：Tsukamoto Yoshihisa

  公开号：US20100041555A1

  公开（公告）日：2010-02-18

  A compound represented by the formula: [wherein R 1 represents a hydrogen atom, a halogen atom, alkyl group, etc., R 2 represents a hydrogen atom, a halogen atom, alkyl group, etc., R 3 , R 4 , R 5 , R 6 and R 7 each independently represent a hydrogen atom, a halogen atom, a substitutable alkyl group, a substitutable alkenyl group, alkynyl group, a substitutable cycloalkyl group, etc., or R 3 , R 4 , R 5 , R 6 and R 7 may form a ring which may be substituted, which is formed by the adjacent two of them with carbon atoms to which the respective substituents are bonded, m and n each independently represent 0 or 1.] a salt thereof, an ester derivative thereof and an agricultural chemical containing the same as an effective ingredient, and a herbicidal composition containing the compound and a second herbicidally active compound as effective ingredients.

  一种化合物，其化学式为：[其中R1代表氢原子、卤素原子、烷基等，R2代表氢原子、卤素原子、烷基等，R3、R4、R5、R6和R7各自独立地代表氢原子、卤素原子、可替换的烷基、可替换的烯基、炔基、可替换的环烷基等，或R3、R4、R5、R6和R7可形成一个环，该环可以被取代，由它们中的相邻两个碳原子形成，各自带有相应的取代基，m和n各自独立地代表0或1。]其盐、酯衍生物和含有该化合物作为有效成分的农药，以及含有该化合物和第二种除草活性化合物作为有效成分的除草剂组合物。