trimethyl-2-(2,4,6-trimethylphenyl)thiophene | 1451066-43-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: trimethyl-2-(2,4,6-trimethylphenyl)thiophene
• 英文别名: 2,3,4-Trimethyl-5-(2,4,6-trimethylphenyl)thiophene；2,3,4-trimethyl-5-(2,4,6-trimethylphenyl)thiophene
• CAS: 1451066-43-5
• 化学式: C₁₆H₂₀S
• 分子量: 244.401
• InChiKey: LBOHPOSJEIGFDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2,3,5-三甲基噻吩 、 均三甲苯 在 三氟化硼乙醚 、 [双(三氟乙酰氧基)碘]苯 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以38%的产率得到trimethyl-2-(2,4,6-trimethylphenyl)thiophene
  参考文献：
  名称：

  HYPERVALENT IODINE INDUCED OXIDATIVE CROSS COUPLING VIA Thiophene CATION RADICAL INTERMEDIATE

  摘要：

  The hypervalent iodine-induced arene cross coupling via a single-electron-transfer (SET) oxidation process could proceed in some extent even in heteroaromatic compounds, that is, several types thiophenes 1, using alkyl benzenes 2 as coupling partners. The structure of the obtainable heteroaromatic biaryl products could be elaborated by utilizing the known metal-catalyzed coupling technology, i.e., Negishi cross coupling, for the synthesis of multiple arylated (bi)thiophenes.

  DOI：

  10.3987/com-12-s(n)39

文献信息

• HYPERVALENT IODINE INDUCED OXIDATIVE CROSS COUPLING VIA Thiophene CATION RADICAL INTERMEDIATE
  作者：Yasuyuki Kita、Toshifumi Dohi、Motoki Ito、Sho Sekiguchi、Yohei Ishikado

  DOI：10.3987/com-12-s(n)39

  日期：——

  The hypervalent iodine-induced arene cross coupling via a single-electron-transfer (SET) oxidation process could proceed in some extent even in heteroaromatic compounds, that is, several types thiophenes 1, using alkyl benzenes 2 as coupling partners. The structure of the obtainable heteroaromatic biaryl products could be elaborated by utilizing the known metal-catalyzed coupling technology, i.e., Negishi cross coupling, for the synthesis of multiple arylated (bi)thiophenes.