2-异腈甲基吡啶 | 60148-13-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-异腈甲基吡啶
• 英文名称: (2-Pyridylmethyl)isonitrile
• 英文别名: (2-Pyridylmethyl)-isocyanid；2-(Isocyanomethyl)pyridine
• CAS: 60148-13-2
• 化学式: C₇H₆N₂
• mdl: MFCD02664553
• 分子量: 118.138
• InChiKey: QDGBDMBHUVUXRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  17.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氨甲基吡啶 、 氯仿 在 sodium hydroxide 、 四丙基溴化铵 作用下， 以 乙二醇二甲醚 为溶剂， 反应 4.5h， 以25%的产率得到咪唑并[1,5-a]吡啶
  参考文献：
  名称：

  Formation of imidazopyridines by the phase transfer catalyzed reaction of .alpha.-(aminomethyl)pyridines and CHCl3 with alkaline hydroxide

  摘要：

  The reaction of chloroform with 2-(aminomethyl)pyridine (1) under basic phase-transfer catalysis affords the highly fluorescent imidazo[1,5-alpha]pyridine (2) in 25% isolated yield. Despite the formation of considerable tarry residue, GC-MS indicates that the volatile fraction of the reaction is simple and consists of 2 and two minor residue, GC-MS indicates that the volatile fraction of the reaction is simple and consists of 2 and two minor components identified as N-(2-pyridylmethyl)formamide (6) and (2-pyridylmethyl)isonitrile (7). The basic phase transfer catalyzed reaction of chloroform with a series of alpha-(aminomethyl)azanaphthalenes was found to be general and yield the corresponding annulated imidazo derivaties in comparable yields. Despite product yields in the 25% range, GC of the reaction mixtures indicates that the volatile fractions generally consist of residual starting aminomethyl compound, the imidazo product, and a minor amount of the (alpha-azanaphthylmethyl)formamide. However, 3-(aminomethyl)isoquinoline (18) failed to provide any of the expected imidazo[1,5-b]isoquinoline (19). The failure to detect 19 was investigated.

  DOI：

  10.1021/jo00007a028

文献信息

• Methods and compositions for treating diseases associated with pathogenic proteins
  申请人：Chiang K. Peter

  公开号：US20070179123A1

  公开（公告）日：2007-08-02

  Methods and compositions are provided comprising a therapeutically effective amount of a compound of formula I wherein R 1-4 , W, X, Y and Z are as defined in the specification, for inhibiting and treating diseases and disorders associated with pathogenic proteins causing neurodegenerative diseases and amyloid diseases, such as protease resistant prion proteins (PrP Sc ) and those associated with transmissible spongiform encephalopathies (TSEs), Alzheimer's Disease, amyloidosis, and the like.

  提供了一种方法和组合物，包括公式I中化合物的治疗有效量，其中R1-4，W，X，Y和Z如规范中所定义，用于抑制和治疗与致病蛋白质相关的疾病和障碍，这些致病蛋白质导致神经退行性疾病和淀粉样疾病，如蛋白酶抵抗性朊病毒蛋白（PrPSc）和与可传播性海绵状脑病（TSEs），阿尔茨海默病，淀粉样变性等相关的蛋白质。
• PROBE FOR A BIOLOGICAL SPECIMEN AND LABELLING METHOD AND SCREENING METHOD USING THE PROBE
  申请人：Shintou Taichi

  公开号：US20110243850A1

  公开（公告）日：2011-10-06

  Provided is a novel probe for a biological specimen for labelling by itself and clearly visualizing one of a specific cell and a specific cell organ in a living body, the probe having excellent spectral characteristics and exhibiting excellent storage stability. The probe for a biological specimen contains, as an active agent, at least one kind of compound represented by a general formula (I).
• FTO Inhibitors
  申请人：National Institute of Biological Sciences, Beijing

  公开号：US20180118665A1

  公开（公告）日：2018-05-03

  The invention provides compounds that inhibit FTO (fat mass and obesity), including pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof, particularly obesity, with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
• US9801960B2
  申请人：——

  公开号：US9801960B2

  公开（公告）日：2017-10-31
• Formation of imidazopyridines by the phase transfer catalyzed reaction of .alpha.-(aminomethyl)pyridines and CHCl3 with alkaline hydroxide
  作者：Kevin C. Langry

  DOI：10.1021/jo00007a028

  日期：1991.3

  The reaction of chloroform with 2-(aminomethyl)pyridine (1) under basic phase-transfer catalysis affords the highly fluorescent imidazo[1,5-alpha]pyridine (2) in 25% isolated yield. Despite the formation of considerable tarry residue, GC-MS indicates that the volatile fraction of the reaction is simple and consists of 2 and two minor residue, GC-MS indicates that the volatile fraction of the reaction is simple and consists of 2 and two minor components identified as N-(2-pyridylmethyl)formamide (6) and (2-pyridylmethyl)isonitrile (7). The basic phase transfer catalyzed reaction of chloroform with a series of alpha-(aminomethyl)azanaphthalenes was found to be general and yield the corresponding annulated imidazo derivaties in comparable yields. Despite product yields in the 25% range, GC of the reaction mixtures indicates that the volatile fractions generally consist of residual starting aminomethyl compound, the imidazo product, and a minor amount of the (alpha-azanaphthylmethyl)formamide. However, 3-(aminomethyl)isoquinoline (18) failed to provide any of the expected imidazo[1,5-b]isoquinoline (19). The failure to detect 19 was investigated.