1-methyl-3,5,6-triphenylpyridin-2(1H)-one | 1256971-34-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-methyl-3,5,6-triphenylpyridin-2(1H)-one
• 英文别名: 1-Methyl-3,5,6-triphenylpyridin-2-one；1-methyl-3,5,6-triphenylpyridin-2-one
• CAS: 1256971-34-2
• 化学式: C₂₄H₁₉NO
• 分子量: 337.421
• InChiKey: RHUMHWQIBZCLMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-苯基丙烯酸 在 [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 copper(II) acetate monohydrate 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 2-甲基-2-丁醇 、 乙腈 为溶剂， 反应 22.08h， 生成 1-methyl-3,5,6-triphenylpyridin-2(1H)-one
  参考文献：
  名称：

  Ruthenium-Catalyzed Oxidative Synthesis of 2-Pyridones through C–H/N–H Bond Functionalizations

  摘要：

  An Inexpensive ruthenium catalyst enabled oxidative annulations of alkynes by acrylamides with ample scope, which allowed for the preparation of 2-pyridones employing various electron-rich and electron-deficient acrylamides as well as (di)aryl- and (di)alkyl-substituted alkynes.

  DOI：

  10.1021/ol201244s

文献信息

• Synthesis of 2-Pyridones and Iminoesters via Rh(III)-Catalyzed Oxidative Coupling between Acrylamides and Alkynes
  作者：Yan Su、Miao Zhao、Keli Han、Guoyong Song、Xingwei Li

  DOI：10.1021/ol102306c

  日期：2010.12.3

  Catalytic oxidative coupling between acrylamides and alkynes was achieved using 0.5 mol % loading of [RhCp*Cl-2](2) with Cu(OAc)(2) as an oxidant. 2-Pyridones, iminoesters, and substituted indoles could be obtained as a result of the electronic and steric effects of the substituents in the acrylamides.
• Ruthenium-Catalyzed Oxidative Synthesis of 2-Pyridones through C–H/N–H Bond Functionalizations
  作者：Lutz Ackermann、Alexander V. Lygin、Nora Hofmann

  DOI：10.1021/ol201244s

  日期：2011.6.17

  An Inexpensive ruthenium catalyst enabled oxidative annulations of alkynes by acrylamides with ample scope, which allowed for the preparation of 2-pyridones employing various electron-rich and electron-deficient acrylamides as well as (di)aryl- and (di)alkyl-substituted alkynes.