2-(4-Chlorophenyl)-2-hydroxymethyloxirane | 118666-24-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-Chlorophenyl)-2-hydroxymethyloxirane
• 英文别名: [2-(4-chlorophenyl)oxiran-2-yl]methanol
• CAS: 118666-24-3
• 化学式: C₉H₉ClO₂
• 分子量: 184.622
• InChiKey: YWKNOXACSQMHTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  32.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(4-Chlorophenyl)-2-hydroxymethyloxirane 、 1H-1,2,4-三唑 生成 2-(4-chlorophenyl)-3-(1H-1,2,4-triazol-1-yl)-1,2-propanediol
  参考文献：
  名称：

  SAKSENA, ANIL K.;COOPER, ALAN B.;GUZIK, HENRY;GIRIJAVALLABHAN, VIYOOR M.;+

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(4-chlorophenyl)prop-2-en-1-ol 生成 2-(4-Chlorophenyl)-2-hydroxymethyloxirane
  参考文献：
  名称：

  SAKSENA, ANIL K.;COOPER, ALAN B.;GUZIK, HENRY;GIRIJAVALLABHAN, VIYOOR M.;+

  摘要：

  DOI：

文献信息

• SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS
  申请人：Gilbert Eric J.

  公开号：US20130072468A1

  公开（公告）日：2013-03-21

  Compounds of Formula (I): or pharmaceutically acceptable salts, solvates, or esters thereof, are useful in treating diseases or conditions mediated by CB 1 receptors, such as metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, addiction (e.g., smoking cessation), gastrointestinal disorders, and cardiovascular conditions.

  式(I)的化合物或其药用可接受的盐、溶剂合物或酯类物，在治疗由CB1受体介导的疾病或症状方面具有用处，如代谢综合征和肥胖症、神经炎症性疾病、认知障碍和精神病、成瘾（如戒烟）、胃肠道疾病和心血管疾病。
• 2,4,4-tri- and 2,2,4,4-tetra substituted-1,3-dioxolane antifungal,
  申请人：Schering Corporation

  公开号：US04788190A1

  公开（公告）日：1988-11-29

  Novel 1,3-dioxolane compounds useful as antifungal and antiallergy agents and represented by the formula ##STR1## wherein Ar is thienyl, pyridyl, biphenyl, phenyl or phenyl substituted by one or more of halo, nitro, cyano, lower alkyl, lower alkoxy or perhalo(lower)alkyl; Y is CH or N; Q is ##STR2## W is --NR.sub.5 --, --O--, --S(O).sub.n --; X is NO.sub.2, NR.sub.6 R.sub.7 or COR.sub.8 ; R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently hydrogen or lower alkyl; R.sub.5 is hydrogen, lower alkyl or (C.sub.2 -C.sub.6) alkanoyl; R.sub.6 and R.sub.7 are independently hydrogen, lower alkyl, phenyl or phenyl substituted by one or more of halo, perhalo loweralkyl, (C.sub.2 -C.sub.6)alkanoyl lower alkyl, lower alkoxy or 2-loweralkyl-3-oxo-1,2,4-trirazol-4-yl or R.sub.6 and R.sub.7 taken together with the nitrogen atom in NR.sub.6 R.sub.7 form substituted or unsubstituted heterocyclyl, said heterocyclyl substituents being (C.sub.2 -C.sub.6)alkanoyl, lower alkyl, phenyl or phenyl substituted by one or more of halo, perhaloloweralkyl, (C.sub.2 -C.sub.6)alkanoyl, loweralkyl, lower alkoxy or 2-loweralkyl-3-oxo-1,2,4-triazol-4-yl and R.sub.8 is lower alkyl, lower alkoxy, --NR.sub.1 R.sub.2, phenyl or phenyl substituted by one or more of halo, perhalo lower alkyl, lower alkyl, lower alkoxy, nitro, cyano or (C.sub.2 -C.sub.6)alkanoyl and p is 0, 1, 2, 3, 4 or 5 and n is 0, 1, or 2 and the stereochemical isomers thereof in racemic or optically active form; or a pharmaceutically acceptable salt thereof.

  Novel 1,3-二氧杂环己烷化合物，可用作抗真菌和抗过敏剂，其化学式为##STR1##其中Ar是噻吩基，吡啶基，联苯基，苯基或被一种或多种卤素，硝基，氰基，低碳基，低碳氧基或全卤素（低）碳基取代的苯基; Y是CH或N; Q是##STR2##W是--NR.sub.5 --，--O--，--S(O).sub.n --; X是NO.sub.2，NR.sub.6 R.sub.7或COR.sub.8; R.sub.1，R.sub.2，R.sub.3和R.sub.4独立地是氢或低碳基; R.sub.5是氢，低碳基或（C.sub.2 -C.sub.6）烷酰基; R.sub.6和R.sub.7独立地是氢，低碳基，苯基或被一种或多种卤素，全卤素低碳基，（C.sub.2 -C.sub.6）烷酰基低碳基，低碳氧基或2-低碳基-3-氧代-1,2,4-三唑-4-基苯基或R.sub.6和R.sub.7与NR.sub.6 R.sub.7中的氮原子一起形成取代或未取代的杂环基，所述杂环基取代基为（C.sub.2 -C.sub.6）烷酰基，低碳基，苯基或被一种或多种卤素，全卤素低碳基，（C.sub.2 -C.sub.6）烷酰基，低碳基，低碳氧基或2-低碳基-3-氧代-1,2,4-三唑-4-基苯基；R.sub.8是低碳基，低碳氧基，--NR.sub.1 R.sub.2，苯基或被一种或多种卤素，全卤素低碳基，低碳基，低碳氧基，硝基，氰基或（C.sub.2 -C.sub.6）烷酰基; p为0, 1, 2, 3, 4或5，n为0, 1或2，其立体异构体为外消旋或光学活性形式；或其药学上可接受的盐。
• 2,4,4-Tri- and 2,2,4,4-tetra-substituted-1,3-dioxolane
  申请人：SCHERING CORPORATION

  公开号：EP0278105A1

  公开（公告）日：1988-08-17

  2,4,4-tri- and 2,2,4,4-tetra substituted-1,3-­dioxolane compounds and pharmaceutically acceptable salts and solvates thereof are disclosed which possess anti-­fungal, anti-allergy, anti-inflammatory and/or immuno-­modulation activity. Methods for preparing and using the compounds also are described.

  公开了具有抗真菌、抗过敏、抗炎和/或免疫调节活性的 2,4,4- 三取代和 2,2,4,4- 四取代-1,3-二氧戊环化合物及其药学上可接受的盐和溶液。此外，还描述了制备和使用这些化合物的方法。
• [EN] 2,4,4-TRI- AND 2,2,4,4-TETRA SUBSTITUTED-1,3-DIOXOLANE COMPOUNDS
  申请人：SCHERING CORPORATION

  公开号：WO1988005048A1

  公开（公告）日：1988-07-14

  (EN) 2,4,4-tri- and 2,2,4,4-tetra substituted-1,3-dioxolane compounds and pharmaceutically acceptable salts and solvates thereof which possess anti-fungal, anti-allergy, anti-inflammatory and/or immuno modulation activity. Methods for preparing and using the compounds also are described.(FR) Ces composés et leurs sels et solvats acceptables sur le plan pharmaceutique possèdent des propriétés antimycosiques, antiallergiques, anti-inflammatoires et/ou immunomodulatrices. Les modes de préparation et les utilisations de ces composés sont également décrits.

  2,4,4-三取代和2,2,4,4-四取代-1,3-间二甲基呋喃类化合物及其 pharmaceutically acceptable盐和溶剂，这些化合物具有抗真菌、抗过敏、抗炎及/或免疫调节活性。合成及其应用方式亦被描述。
• SAKSENA, ANIL K.;COOPER, ALAN B.;GUZIK, HENRY;GIRIJAVALLABHAN, VIYOOR M.;+
  作者：SAKSENA, ANIL K.、COOPER, ALAN B.、GUZIK, HENRY、GIRIJAVALLABHAN, VIYOOR M.、+

  DOI：——

  日期：——