13-(2,4-dichlorophenyl)-13H-benzo[g]benzothiazolo[2,3-b]quinazoline-5,14-dione | 1580462-39-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 13-(2,4-dichlorophenyl)-13H-benzo[g]benzothiazolo[2,3-b]quinazoline-5,14-dione
• 英文别名: 2-(2,4-Dichlorophenyl)-10-thia-3,12-diazapentacyclo[11.8.0.03,11.04,9.015,20]henicosa-1(13),4,6,8,11,15,17,19-octaene-14,21-dione；2-(2,4-dichlorophenyl)-10-thia-3,12-diazapentacyclo[11.8.0.03,11.04,9.015,20]henicosa-1(13),4,6,8,11,15,17,19-octaene-14,21-dione
• CAS: 1580462-39-0
• 化学式: C₂₄H₁₂Cl₂N₂O₂S
• 分子量: 463.343
• InChiKey: FVMRQZQAFLSCBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  31
• 可旋转键数：
  1
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  75
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氨基苯并噻唑 、 2-羟基-1,4-萘醌 、 2,4-二氯苯甲醛 在 amberlyst-15 作用下， 以 neat (no solvent) 为溶剂， 反应 3.0h， 以79%的产率得到13-(2,4-dichlorophenyl)-13H-benzo[g]benzothiazolo[2,3-b]quinazoline-5,14-dione
  参考文献：
  名称：

  Synthesis and antiproliferative evaluation of 13-aryl-13H-benzo[g]benzothiazolo [2,3-b]quinazoline-5,14-diones

  摘要：

  A simple synthesis of novel 13-aryl-13H-benzo[g] benzothiazolo [2,3-b] quinazoline-5,14-dione derivatives was accomplished in excellent yields via the reaction of 2-aminobenzothiazole, aromatic aldehydes and 2-hydroxy-1,4-naphthoquinone in the presence of amberlyst-15. The antiproliferative activities of all the synthesized compounds were assessed on two different human cancer cell lines (HepG2 and Hela), and the results showed that most of the new compounds showed good to potent cytotoxic activities. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.02.018

文献信息

• Synthesis and antiproliferative evaluation of 13-aryl-13H-benzo[g]benzothiazolo [2,3-b]quinazoline-5,14-diones
  作者：Liqiang Wu、Chong Zhang、Weilin Li

  DOI：10.1016/j.bmcl.2014.02.018

  日期：2014.3

  A simple synthesis of novel 13-aryl-13H-benzo[g] benzothiazolo [2,3-b] quinazoline-5,14-dione derivatives was accomplished in excellent yields via the reaction of 2-aminobenzothiazole, aromatic aldehydes and 2-hydroxy-1,4-naphthoquinone in the presence of amberlyst-15. The antiproliferative activities of all the synthesized compounds were assessed on two different human cancer cell lines (HepG2 and Hela), and the results showed that most of the new compounds showed good to potent cytotoxic activities. (C) 2014 Elsevier Ltd. All rights reserved.