N-(2-Diphenylphosphinoyl-1-phenylethyl)-N-phenylurea | 125295-05-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-Diphenylphosphinoyl-1-phenylethyl)-N-phenylurea
• 英文别名: 1-(2-Diphenylphosphoryl-1-phenylethyl)-1-phenylurea
• CAS: 125295-05-8
• 化学式: C₂₇H₂₅N₂O₂P
• 分子量: 440.481
• InChiKey: UJBHUFFOEVNYRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  63.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (2-Anilino-2-phenylethyl)diphenylphosphine N-ethoxycarbonylimide 在 potassium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以82%的产率得到N-(2-Diphenylphosphinoyl-1-phenylethyl)-N-phenylurea
  参考文献：
  名称：

  Diastereofacial Selectivity in the Reaction of (C-1)-Metalated Alkyldiphenylphosphine Imides with Schiff Bases

  摘要：

  erythro-2-Anilinoalkyldiphenyphosphine phenylimides are obtained by reaction of (C-1)-metalated alkyldiphenylphosphine imides with aldimines in a diastereoselective fashion. Reaction of the products with carbon dioxide or with lithium aluminum hydride leads to 2-anilinoalkyldiphenylphosphine oxides or 2-anilinoalkyldiphenylphosphines, respectively.

  DOI：

  10.1055/s-1989-27230

文献信息

• BARLUENGA, JOSE;LOPEZ, FERNANDO;PALACIOS, FRANCISCO, SYNTHESIS,(1989) N, C. 298-300
  作者：BARLUENGA, JOSE、LOPEZ, FERNANDO、PALACIOS, FRANCISCO

  DOI：——

  日期：——
• Diastereofacial Selectivity in the Reaction of (<i>C</i>-1)-Metalated Alkyldiphenylphosphine Imides with Schiff Bases
  作者：José Barluenga、Fernando López、Francisco Palacios

  DOI：10.1055/s-1989-27230

  日期：——

  erythro-2-Anilinoalkyldiphenyphosphine phenylimides are obtained by reaction of (C-1)-metalated alkyldiphenylphosphine imides with aldimines in a diastereoselective fashion. Reaction of the products with carbon dioxide or with lithium aluminum hydride leads to 2-anilinoalkyldiphenylphosphine oxides or 2-anilinoalkyldiphenylphosphines, respectively.

  erythro-2-Anilinoalkyldiphenyphosphine phenylimides are obtained by reaction of (C-1)-metalated alkyldiphenylphosphine imides with aldimines in a diastereoselective fashion. Reaction of the products with carbon dioxide or with lithium aluminum hydride leads to 2-anilinoalkyldiphenylphosphine oxides or 2-anilinoalkyldiphenylphosphines, respectively.